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Safety and Tolerability of Hydroxychloroquine in healthcare workers and first responders for the prevention of COVID-19: WHIP COVID-19 Study

McKinnon et al., International Journal of Infectious Diseases, doi:10.1016/j.ijid.2021.12.343, WHIP COVID-19, NCT04341441 (history)

McKinnon et al., Safety and Tolerability of Hydroxychloroquine in healthcare workers and first responders for the prevention of.., International Journal of Infectious Diseases, doi:10.1016/j.ijid.2021.12.343, WHIP COVID-19, NCT04341441

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HCQ prophylaxis RCT with 201 weekly HCQ patients, 197 daily HCQ patients, and 200 control patients, concluding the prophylaxis is safe. There were no grade 3 or 4 AEs, SAEs, ER visits, or hospitalizations. There was only 4 confirmed cases, 2 in the placebo arm and one in each HCQ arm. 60% of patients had exposure at baseline.

HCQ 400mg weekly or HCQ 200mg daily after a loading dose of 400mg on day 1.

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risk of symptomatic case, 2.5% lower, RR 0.98, p = 1.00, treatment 2 of 365 (0.5%), control 1 of 178 (0.6%), NNT 7219, daily and weekly HCQ combined.

risk of symptomatic case, no change, RR 1.00, p = 1.00, treatment 1 of 178 (0.6%), control 1 of 178 (0.6%), daily HCQ.

risk of symptomatic case, 4.8% lower, RR 0.95, p = 1.00, treatment 1 of 187 (0.5%), control 1 of 178 (0.6%), NNT 3698, weekly HCQ.

risk of symptomatic case, 53.3% lower, RR 0.47, p = 1.00, treatment 0 of 25 (0.0%), control 1 of 178 (0.6%), NNT 178, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), AD patients.

risk of case, 51.2% lower, RR 0.49, p = 0.60, treatment 2 of 365 (0.5%), control 2 of 178 (1.1%), NNT 174, daily and weekly HCQ combined.

risk of case, 50.0% lower, RR 0.50, p = 1.00, treatment 1 of 178 (0.6%), control 2 of 178 (1.1%), NNT 178, daily HCQ.

risk of case, 52.4% lower, RR 0.48, p = 0.61, treatment 1 of 187 (0.5%), control 2 of 178 (1.1%), NNT 170, weekly HCQ.

risk of case, 69.5% lower, RR 0.30, p = 1.00, treatment 0 of 25 (0.0%), control 2 of 178 (1.1%), NNT 89, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), AD patients.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

McKinnon et al., 23 Dec 2021, Double Blind Randomized Controlled Trial, USA, peer-reviewed, 10 authors, trial NCT04341441 (history) (WHIP COVID-19).

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Safety and tolerability of hydroxychloroquine in health care workers and first responders for the prevention of COVID-19: WHIP COVID-19 Study

MD, MSc John E Mckinnon, Dee Dee Wang, Marcus Zervos, Matt Saval, Laurie Marshall-Nightengale, Paul Kilgore, Pardeep Pabla, Ed Szandzik, Kathleen Maksimowicz-Mckinnon, Safety William W O'neill

International Journal of Infectious Diseases, doi:10.1016/j.ijid.2021.12.343

This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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