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Clinical characteristics of COVID-19 patients hospitalized at Clinique Ngaliema, a public hospital in Kinshasa, in the Democratic Republic of Congo: A retrospective cohort study

Matangila et al., PLoS ONE, doi:10.1371/journal.pone.0244272
Dec 2020  
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Mortality 55% Improvement Relative Risk HCQ for COVID-19  Matangila et al.  LATE TREATMENT Is late treatment with HCQ beneficial for COVID-19? Retrospective 160 patients in DR Congo Lower mortality with HCQ (not stat. sig., p=0.21) c19hcq.org Matangila et al., PLoS ONE, December 2020 FavorsHCQ Favorscontrol 0 0.5 1 1.5 2+
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now with p < 0.00000000001 from 417 studies, recognized in 46 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,800+ studies for 102 treatments. c19hcq.org
55% lower death with HCQ+AZ. Retrospective 160 hospitalized patients in the Democratic Republic of Congo, 92% receiving HCQ+AZ, showing adjusted OR 0.24 [0.03-2.2].
risk of death, 54.9% lower, RR 0.45, p = 0.21, treatment 25 of 147 (17.0%), control 8 of 13 (61.5%), NNT 2.2, adjusted per study, odds ratio converted to relative risk.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Matangila et al., 18 Dec 2020, retrospective, DR Congo, peer-reviewed, median age 54.0, 12 authors, average treatment delay 7.0 days.
This PaperHCQAll
Clinical characteristics of COVID-19 patients hospitalized at Clinique Ngaliema, a public hospital in Kinshasa, in the Democratic Republic of Congo: A retrospective cohort study
Junior Rika Matangila, Ritha Kibambe Nyembu, Gloire Mosala Telo, Christian Djuba Ngoy, Taty Msueun Sakobo, Joel Mbembo Massolo, Blandine Mbo Muyembe, Richard Kapela Mvwala, Cedric Kabemba Ilunga, Emmanuel Bakilo Limbole, Jeff Mukengeshay Ntalaja, Roger Minga Kongo
PLOS ONE, doi:10.1371/journal.pone.0244272
Objectives To describe the clinical characteristics of patients infected with SARS-CoV-2 at Clinique Ngaliema, a public hospital, in Kinshasa, in the Democratic Republic of Congo (DRC). Methods This retrospective study analyzed medical records including socio-demographics, past medical history, clinical manifestation, comorbidities, laboratory data, treatment and disease outcome of 160 hospitalized COVID-19 patients, with confirmed result of SARS-CoV-2 viral infection. Results The median age of patients was 54 years (IQR: 38-64), and there was no significant gender difference (51% of male). The most common comorbidities were hypertension (55 [34%]), diabetes (31 [19%]) and obesity (13 [8%]). Fever (93 [58%]), cough (92 [57%]), fatigue (87 [54%]), shortness of breath (72 [45%]) and myalgia (33 [21%]) were the most common symptoms, upon admission. Patients were categorized into mild (92 [57%]), moderate (19 [12%]) and severe (49 [31%]). Severe patients were older and were more likely to have comorbidities, compared to mild ones. The majority of patients (92% [147 of 160]) patients received hydroxychloroquine or chloroquine phosphate. Regression model revealed that older age, lower SpO2, higher heart rate and elevated AST at admission were all risk factors
Supporting information S1
References
Bezzio, Saibeni, Variola, Allocca, Massari et al., Outcomes of COVID-19 in 79 patients with IBD in Italy: an IG-IBD study, Gut, doi:10.1136/gutjnl-2020-321411
Chen, Zhou, Dong, Qu, Gong et al., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study, Lancet, doi:10.1016/S0140-6736%2820%2930211-7
Doumas, Patoulias, Katsimardou, Stavropoulos, Imprialos et al., COVID19 and increased mortality in African Americans: socioeconomic differences or does the renin angiotensin system also contribute?, J Hum Hypertens, doi:10.1038/s41371-020-0380-y
Giudicessi, Roden, Wilde, Ackerman, Genetic susceptibility for COVID-19-associated sudden cardiac death in African Americans, Heart Rhythm, doi:10.1016/j.hrthm.2020.04.045
Guan, Ni, Hu, Liang, Ou et al., Clinical Characteristics of Coronavirus Disease 2019 in China, N Engl J Med, doi:10.1056/NEJMoa2002032
Han, Yang, Liu, Liu, Wu et al., Prominent changes in blood coagulation of patients with SARS-CoV-2 infection, Clin Chem Lab Med, doi:10.1515/cclm-2020-0188
Iaccarino, Grassi, Borghi, Ferri, Salvetti et al., Age and Multimorbidity Predict Death Among COVID-19 Patients: Results of the SARS-RAS Study of the Italian Society of Hypertension, Hypertension, doi:10.1161/HYPERTENSIONAHA.120.15324
Ielapi, Licastro, Provenzano, Andreucci, Franciscis et al., Cardiovascular disease as a biomarker for an increased risk of COVID-19 infection and related poor prognosis, Biomark Med, doi:10.2217/bmm-2020-0201
Kazadi, Sexton, Bigonsa, Okanga, Malaria in primary school children and infants in kinshasa, democratic republic of the congo: surveys from the 1980s and 2000, Am J Trop Med Hyg
Lei, Liu, Zhou, Qin, Zhang et al., Longitudinal association between markers of liver injury and mortality in COVID-19 in China, Hepatology, doi:10.1002/hep.31301
Li, Guan, Wu, Wang, Zhou et al., Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia, N Engl J Med, doi:10.1056/NEJMoa2001316
Liu, Fang, Deng, Liu, Wang et al., Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province, Chin Med J (Engl, doi:10.1097/CM9.0000000000000744
Liu, Tao, Wang, Yuan, Liu et al., Analysis of factors associated with disease outcomes in hospitalized patients with 2019 novel coronavirus disease, Chin Med J (Engl, doi:10.1097/CM9.0000000000000775
Mandina, Makulo, Bepouka, Longokolo, Odio et al., Expe ´rience pre ´coce de la re ´ponse à la pande ´mie à Syndrome Respiratoire Aigu Se ´vère à Coronavirus SARS-COV 2 appele áussi corona Virus disease 19 (COVID-19) aux Cliniqes Universitaires de Kinshasa, Ann. Afr. Med
Nkengasong, Mankoula, Looming threat of COVID-19 infection in Africa: act collectively, and fast, Lancet, doi:10.1016/S0140-6736%2820%2930464-5
Parohan, Yaghoubi, Seraji, Liver injury is associated with severe coronavirus disease 2019 (COVID-19) infection: A systematic review and meta-analysis of retrospective studies, Hepatol Res, doi:10.1111/hepr.13510
Simbana-Rivera, COVID-19) and the SARS-CoV-2 virus in Latin America and the Caribbean: Morbidity, Mortality and Molecular Testing Trends in the Region
Sun, Koh, Marimuthu, Ng, Young et al., Epidemiological and Clinical Predictors of COVID-19, Clin Infect Dis, doi:10.1093/cid/ciaa322
Wan, Xiang, Fang, Zheng, Li et al., Clinical features and treatment of COVID-19 patients in northeast Chongqing, J Med Virol, doi:10.1002/jmv.25783
Wee, Ko, Ho, Kwek, Tan et al., Community-acquired viral respiratory infections amongst hospitalized inpatients during a COVID-19 outbreak in Singapore: co-infection and clinical outcomes, J Clin Virol, doi:10.1016/j.jcv.2020.104436
Who, Coronavirus disease (COVID-19) outbreak
Xie, Covassin, Fan, Singh, Gao et al., Association Between Hypoxemia and Mortality in Patients With COVID-19, Mayo Clin Proc, doi:10.1016/j.mayocp.2020.04.006
Zhao, Li, Wu, Zhao, Wang et al., Clinical features in 52 patients with COVID-19 who have increased leukocyte count: a retrospective analysis, Eur J Clin Microbiol Infect Dis, doi:10.1007/s10096-020-03976-8
Zhou, Yu, Du, Fan, Liu et al., Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study, Lancet, doi:10.1016/S0140-6736%2820%2930566-3
Zhu, Gao, Liu, Xu, Guan et al., Clinical and CT imaging features of 2019 novel coronavirus disease (COVID-19), J Infect
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Older age, ' 'lower SpO2, tachycardia, and elevated AST could help to identify patients at higher risk of ' 'death at an early stage of the illness. <jats:italic>Plasmodium spp</jats:italic> ' 'co-infection was not common in hospitalized COVID-19 patients.</jats:p>\n' '</jats:sec>', 'DOI': '10.1371/journal.pone.0244272', 'type': 'journal-article', 'created': { 'date-parts': [[2020, 12, 18]], 'date-time': '2020-12-18T19:04:54Z', 'timestamp': 1608318294000}, 'page': 'e0244272', 'update-policy': 'http://dx.doi.org/10.1371/journal.pone.corrections_policy', 'source': 'Crossref', 'is-referenced-by-count': 20, 'title': 'Clinical characteristics of COVID-19 patients hospitalized at Clinique Ngaliema, a public ' 'hospital in Kinshasa, in the Democratic Republic of Congo: A retrospective cohort study', 'prefix': '10.1371', 'volume': '15', 'author': [ { 'ORCID': 'http://orcid.org/0000-0002-9025-3604', 'authenticated-orcid': True, 'given': 'Junior Rika', 'family': 'Matangila', 'sequence': 'first', 'affiliation': []}, {'given': 'Ritha Kibambe', 'family': 'Nyembu', 'sequence': 'additional', 'affiliation': []}, {'given': 'Gloire Mosala', 'family': 'Telo', 'sequence': 'additional', 'affiliation': []}, {'given': 'Christian Djuba', 'family': 'Ngoy', 'sequence': 'additional', 'affiliation': []}, {'given': 'Taty Msueun', 'family': 'Sakobo', 'sequence': 'additional', 'affiliation': []}, {'given': 'Joel Mbembo', 'family': 'Massolo', 'sequence': 'additional', 'affiliation': []}, {'given': 'Blandine Mbo', 'family': 'Muyembe', 'sequence': 'additional', 'affiliation': []}, {'given': 'Richard Kapela', 'family': 'Mvwala', 'sequence': 'additional', 'affiliation': []}, {'given': 'Cedric Kabemba', 'family': 'Ilunga', 'sequence': 'additional', 'affiliation': []}, {'given': 'Emmanuel Bakilo', 'family': 'Limbole', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jeff Mukengeshay', 'family': 'Ntalaja', 'sequence': 'additional', 'affiliation': []}, {'given': 'Roger Minga', 'family': 'Kongo', 'sequence': 'additional', 'affiliation': []}], 'member': '340', 'published-online': {'date-parts': [[2020, 12, 18]]}, 'reference': [ { 'key': 'pone.0244272.ref001', 'doi-asserted-by': 'crossref', 'first-page': '1199', 'DOI': '10.1056/NEJMoa2001316', 'article-title': 'Early Transmission Dynamics in Wuhan, China, of Novel ' 'Coronavirus-Infected Pneumonia', 'volume': '382', 'author': 'Q Li', 'year': '2020', 'journal-title': 'N Engl J Med'}, { 'key': 'pone.0244272.ref002', 'unstructured': 'WHO. 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Mars 2020. 18-3-2020."}, { 'key': 'pone.0244272.ref013', 'doi-asserted-by': 'crossref', 'first-page': '1025', 'DOI': '10.1097/CM9.0000000000000744', 'article-title': 'Clinical characteristics of novel coronavirus cases in tertiary ' 'hospitals in Hubei Province', 'volume': '133', 'author': 'K Liu', 'year': '2020', 'journal-title': 'Chin Med J (Engl)'}, { 'key': 'pone.0244272.ref014', 'doi-asserted-by': 'crossref', 'first-page': '1054', 'DOI': '10.1016/S0140-6736(20)30566-3', 'article-title': 'Clinical course and risk factors for mortality of adult inpatients with ' 'COVID-19 in Wuhan, China: a retrospective cohort study', 'volume': '395', 'author': 'F Zhou', 'year': '2020', 'journal-title': 'Lancet'}, { 'key': 'pone.0244272.ref015', 'doi-asserted-by': 'crossref', 'first-page': '797', 'DOI': '10.1002/jmv.25783', 'article-title': 'Clinical features and treatment of COVID-19 patients in northeast ' 'Chongqing', 'volume': '92', 'author': 'S Wan', 'year': '2020', 'journal-title': 'J Med Virol'}, { 'key': 'pone.0244272.ref016', 'article-title': 'Expérience précoce de la réponse à la pandémie à Syndrome Respiratoire ' 'Aigu Sévère à Coronavirus SARS-COV 2 appelé aussi corona Virus disease ' '19 (COVID-19) aux Cliniqes Universitaires de Kinshasa', 'author': 'MN Mandina', 'year': '2020', 'journal-title': 'Ann. 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Late treatment
is less effective
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