0
0.5
1
1.5
2+
Mortality
55%
Improvement
Relative Risk
c19 hcq.org
Matangila et al. HCQ for COVID-19 LATE TREATMENT
Favors HCQ
Favors control
Clinical characteristics of COVID-19 patients hospitalized at Clinique Ngaliema, a public hospital in Kinshasa, in the Democratic Republic of Congo: A retrospective cohort study
Matangila et al. ,
Clinical characteristics of COVID-19 patients hospitalized at Clinique Ngaliema, a public hospital in.. ,
PLoS ONE, doi:10.1371/journal.pone.0244272
55% lower death with HCQ+AZ. Retrospective 160 hospitalized patients in the Democratic Republic of Congo, 92% receiving HCQ+AZ, showing adjusted OR 0.24 [0.03-2.2].
risk of death, 54.9% lower , RR 0.45, p = 0.21 , treatment 25 of 147 (17.0%), control 8 of 13 (61.5%), NNT 2.2, adjusted per study, odds ratio converted to relative risk.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Matangila et al., 18 Dec 2020, retrospective, DR Congo, peer-reviewed, median age 54.0, 12 authors, average treatment delay 7.0 days.
Abstract: PLOS ONE
RESEARCH ARTICLE
Clinical characteristics of COVID-19 patients
hospitalized at Clinique Ngaliema, a public
hospital in Kinshasa, in the Democratic
Republic of Congo: A retrospective cohort
study
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OPEN ACCESS
Citation: Matangila JR, Nyembu RK, Telo GM,
Ngoy CD, Sakobo TM, Massolo JM, et al. (2020)
Clinical characteristics of COVID-19 patients
hospitalized at Clinique Ngaliema, a public hospital
in Kinshasa, in the Democratic Republic of Congo:
A retrospective cohort study. PLoS ONE 15(12):
e0244272. https://doi.org/10.1371/journal.
pone.0244272
Editor: Raffaele Serra, University Magna Graecia of
Catanzaro, ITALY
Received: September 12, 2020
Accepted: December 7, 2020
Published: December 18, 2020
Peer Review History: PLOS recognizes the
benefits of transparency in the peer review
process; therefore, we enable the publication of
all of the content of peer review and author
responses alongside final, published articles. The
editorial history of this article is available here:
https://doi.org/10.1371/journal.pone.0244272
Copyright: © 2020 Matangila et al. This is an open
access article distributed under the terms of the
Creative Commons Attribution License, which
permits unrestricted use, distribution, and
reproduction in any medium, provided the original
author and source are credited.
Data Availability Statement: The data underlying
this study cannot be shared publicly, as it is the
Junior Rika Matangila ID1,2*, Ritha Kibambe Nyembu1,3, Gloire Mosala Telo1, Christian
Djuba Ngoy1, Taty Msueun Sakobo1, Joel Mbembo Massolo1, Blandine Mbo Muyembe1,
Richard Kapela Mvwala1, Cedric Kabemba Ilunga1,4, Emmanuel Bakilo Limbole1, Jeff
Mukengeshay Ntalaja1, Roger Minga Kongo1
1 Clinique Ngaliema, Kinshasa, République Démocratique du Congo, 2 Département de Médecine
Tropicale, Université de Kinshasa, Kinshasa, République Démocratique du Congo, 3 Département de
Biologie Médicale, Cliniques Universitaires de Kinshasa, Kinshasa, République Démocratique du Congo,
4 Département de Médecine Interne, Cliniques Universitaires de Kinshasa, Kinshasa, République
Démocratique du Congo
* matangilaj@yahoo.fr
Abstract
Objectives
To describe the clinical characteristics of patients infected with SARS-CoV-2 at Clinique
Ngaliema, a public hospital, in Kinshasa, in the Democratic Republic of Congo (DRC).
Methods
This retrospective study analyzed medical records including socio-demographics, past
medical history, clinical manifestation, comorbidities, laboratory data, treatment and disease
outcome of 160 hospitalized COVID-19 patients, with confirmed result of SARS-CoV-2 viral
infection.
Results
The median age of patients was 54 years (IQR: 38–64), and there was no significant gender
difference (51% of male). The most common comorbidities were hypertension (55 [34%]),
diabetes (31 [19%]) and obesity (13 [8%]). Fever (93 [58%]), cough (92 [57%]), fatigue (87
[54%]), shortness of breath (72 [45%]) and myalgia (33 [21%]) were the most common
symptoms, upon admission. Patients were categorized into mild (92 [57%]), moderate (19
[12%]) and severe (49 [31%]). Severe patients were older and were more likely to have
comorbidities, compared to mild ones. The majority of patients (92% [147 of 160]) patients
received hydroxychloroquine or chloroquine phosphate. Regression model revealed that
older age, lower SpO2, higher heart rate and elevated AST at admission were all risk factors
PLOS ONE |..
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