Abstract: Martínez-López et al. Blood Cancer Journal (2020)10:103 https://doi.org/10.1038/s41408-020-00372-5 ARTICLE Blood Cancer Journal Open Access Multiple myeloma and SARS-CoV-2 infection: clinical characteristics and prognostic factors of inpatient mortality 1234567890():,; 1234567890():,; 1234567890():,; 1234567890():,; Joaquín Martínez-López 1, María-Victoria Mateos 2, Cristina Encinas3, Anna Sureda4, José Ángel Hernández-Rivas5, Ana Lopez de la Guía6, Diego Conde7, Isabel Krsnik8, Elena Prieto9, Rosalía Riaza Grau10, Mercedes Gironella 11, María Jesús Blanchard12, Nerea Caminos13, Carlos Fernández de Larrea14, María Alicia Senin15, Fernando Escalante16, José Enrique de la Puerta 17, Eugenio Giménez18, Pilar Martínez-Barranco19, Juan José Mateos20, Luis Felipe Casado21, Joan Bladé14, Juan José Lahuerta 1, Javier de la Cruz22 and Jesús San-Miguel 23 Abstract There is limited information on the characteristics, prognostic factors, and outcomes of patients with multiple myeloma (MM) hospitalized with COVID-19. This retrospective case series investigated 167 patients reported from 73 hospitals within the Spanish Myeloma Collaborative Group network in March and April, 2020. Outcomes were compared with 167 randomly selected, contemporary, age-/sex-matched noncancer patients with COVID-19 admitted at six participating hospitals. Among MM and noncancer patients, median age was 71 years, and 57% of patients were male; 75 and 77% of patients, respectively, had at least one comorbidity. COVID-19 clinical severity was moderate–severe in 77 and 89% of patients and critical in 8 and 4%, respectively. Supplemental oxygen was required by 47 and 55% of MM and noncancer patients, respectively, and 21%/9% vs 8%/6% required noninvasive/invasive ventilation. Inpatient mortality was 34 and 23% in MM and noncancer patients, respectively. Among MM patients, inpatient mortality was 41% in males, 42% in patients aged >65 years, 49% in patients with active/progressive MM at hospitalization, and 59% in patients with comorbid renal disease at hospitalization, which were independent prognostic factors on adjusted multivariate analysis. This case series demonstrates the increased risk and identifies predictors of inpatient mortality among MM patients hospitalized with COVID-19.