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COVID-19 incidence and outcomes in a home dialysis unit in Madrid (Spain) at the height of the pandemic

Maldonado et al., Nefrología, doi:10.1016/j.nefro.2020.09.002
Nov 2020  
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Mortality 91% Improvement Relative Risk HCQ for COVID-19  Maldonado et al.  LATE TREATMENT Is late treatment with HCQ beneficial for COVID-19? Retrospective 12 patients in Spain Lower mortality with HCQ (not stat. sig., p=0.17) c19hcq.org Maldonado et al., Nefrología, November 2020 FavorsHCQ Favorscontrol 0 0.5 1 1.5 2+
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now with p < 0.00000000001 from 411 studies, recognized in 46 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 75 treatments. c19hcq.org
Very small retrospective of 12 dialysis patients showing 1/11 deaths with HCQ and 1/1 without HCQ.
This study is excluded in the after exclusion results of meta analysis: treatment or control group size extremely small.
risk of death, 90.9% lower, RR 0.09, p = 0.17, treatment 1 of 11 (9.1%), control 1 of 1 (100.0%), NNT 1.1.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Maldonado et al., 5 Nov 2020, retrospective, Spain, peer-reviewed, 10 authors.
This PaperHCQAll
Incidencia y resultados de la COVID-19 en una unidad de diálisis domiciliaria en Madrid (España) durante el pico de la pandemia
María Maldonado, Marta Ossorio, Gloria Del Peso, Carlos Santos, Laura Álvarez, Rafael Sánchez-Villanueva, Begoña Rivas, Cristina Vega, Rafael Selgas, María A Bajo
Nefrología, doi:10.1016/j.nefro.2020.09.002
Introducción: La enfermedad por coronavirus 2019 (COVID-19) es una infección viral causada por un nuevo coronavirus que está afectando a todo el mundo. Hay estudios previos de pacientes en hemodiálisis en centro, pero hay pocos datos sobre población en diálisis domiciliaria. Nuestro objetivo es estudiar la incidencia y evolución de la COVID-19 en una unidad de diálisis domiciliaria (UDD) durante el pico de la pandemia. Métodos: Estudio observacional y retrospectivo que incluye todos los pacientes diagnosticados de COVID-19 de la UDD del Hospital Universitario La Paz (Madrid, Espa ña) entre el 10 de marzo y el 15 de mayo de 2020. Se recogieron los datos clínicos de la UDD (57 pacientes en diálisis peritoneal y 22 pacientes en hemodiálisis domiciliaria) y comparamos las características clínicas y la evolución de los pacientes con o sin infección por COVID-19. Resultados: Doce pacientes fueron diagnosticados de COVID-19 (9 diálisis peritoneal, 3 hemodiálisis domiciliaria). No hubo diferencias estadísticamente significativas entre las características clínicas de los pacientes con COVID-19 y el resto de la unidad. La edad media fue 62 ± 18,5 a ños; la mayoría eran varones (75%). Todos los pacientes menos uno necesitaron hospitalización. Diez pacientes (83%) fueron dados de alta tras una media de 16,4 ± 9,7 días de hospitalización. Dos pacientes fueron diagnosticados durante su hospitalización por otro motivo y fueron los únicos que fallecieron. Los fallecidos eran de mayor edad que los supervivientes. Conclusión: La incidencia de COVID-19 en nuestra UDD en Madrid durante el pico de la pandemia fue alto, especialmente en los pacientes en diálisis peritoneal, sin observarse un * Autor para correspondencia.
Conflicto de intereses Los autores declaran no tener ningún conflicto de intereses. Agradecimientos Nos gustaría agradecer a todo el equipo de médicos, enfermería, auxiliares de enfermería, celadores, limpieza, administrativos y demás personal del Hospital Universitario La Paz su gran labor durante la pandemia de COVID-19, destacando el gran trabajo en equipo que se realizó. También nos gustaría agradecer a los centros de hemodiálisis asociados al Hospital Universitario La Paz (Centro de Diálisis de Madrid El Pilar [Fresenius Medical Care], Centro de Diálisis Alcobendas [Fresenius Medical Care] y Centro de Diálisis Diaverum Madrid) su importante papel durante la pandemia, al prestar el apoyo logístico necesario para poder concentrar todos los casos COVID-19 positivos en la unidad hospitalaria y derivar los pacientes sanos a dichos centros. b i b l i o g r a f í a
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Late treatment
is less effective
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