Retrospective 689 healthcare workers in India, showing no significant difference in IgG positivity with HCQ prophylaxis in unadjusted results.
This study is excluded in the after exclusion results of meta
unadjusted results with no group details.
Abstract: Am J Blood Res 2021;11(1):44-52
Seroprevalence of IgG against SARS-CoV-2 and its
determinants among healthcare workers of a
COVID-19 dedicated hospital of India
Mala Mahto1, Ayan Banerjee1, Bijit Biswas2, Sushil Kumar1, Neeraj Agarwal2, Prabhat Kumar Singh3
Department of Biochemistry, All India Institute of Medical Sciences, Patna, Bihar, India; 2Department of
Community and Family Medicine, All India Institute of Medical Sciences, Patna, Bihar, India; 3Department of
Anaesthesiology and Critical Care, Director, All India Institute of Medical Sciences, Patna, Bihar, India
Received December 24, 2020; Accepted January 27, 2021; Epub February 15, 2021; Published February 28,
Abstract: Healthcare workers (HCWs) due to their job profile are at utmost risk of contracting severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. Serological survey is an useful tool for vulnerability mapping in
an infectious disease pandemic. The aim of the current study was to assess seroprevalence of IgG against SARSCoV-2 and its determinants among HCWs of a tertiary healthcare facility of India. It was an observational study,
cross-sectional in design conducted among 919 HCWs of All India Institute of Medical Sciences, Patna, Bihar, India
during September, 2020. In results, IgG seroprevalence for SARS-CoV-2 among the study subjects was 13.3% [95%
confidence interval (CI): 11.2-15.6%]. In univariate logistic regression analysis; gender, occupation, place of posting,
use of full personal protective equipment (PPE), prior corona virus disease (COVID)-19 infection, influenza like illness
(ILI), use of steam inhalation, consumption of azithromycin, zinc and vitamin C were the significant attributes which
affected the IgG seropositivity for SARS-CoV-2. In the multivariable logistic regression model; occupation, place of
posting, prior COVID-19 infection and ILI were significant determinants of IgG seropositivity for SARS-CoV-2. To conclude, majority of the HCWs were found to be IgG seronegative for SARS-CoV-2. Till availability of effective vaccine all
of the HCWs should abide by infection prevention and control (IPC) measures to keep themselves and their contacts
protected from SARS-CoV-2.
Keywords: COVID-19, immunoglobulin G, seroepidemiologic studies, health personnel, epidemiologic factors
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