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Seroprevalence of IgG against SARS-CoV-2 and its determinants among healthcare workers of a COVID-19 dedicated hospital of India

Mahto et al., American Journal of Blood Research, 11:1
Feb 2021  
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IgG positive 27% unadjusted Improvement Relative Risk HCQ for COVID-19  Mahto et al.  Prophylaxis Is pre-exposure prophylaxis with HCQ beneficial for COVID-19? Retrospective 689 patients in India Lower IgG positivity with HCQ (not stat. sig., p=0.38) Mahto et al., American J. Blood Research, Feb 2021 FavorsHCQ Favorscontrol 0 0.5 1 1.5 2+
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
*, now with p < 0.00000000001 from 411 studies, recognized in 46 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 79 treatments.
Retrospective 689 healthcare workers in India, showing no significant difference in IgG positivity with HCQ prophylaxis in unadjusted results.
This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details.
Study covers diet, HCQ, vitamin C, and zinc.
risk of IgG positive, 26.9% lower, RR 0.73, p = 0.38, treatment 9 of 89 (10.1%), control 84 of 600 (14.0%), NNT 26, unadjusted, odds ratio converted to relative risk.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Mahto et al., 15 Feb 2021, retrospective, India, peer-reviewed, 6 authors.
This PaperHCQAll
Seroprevalence of IgG against SARS-CoV-2 and its determinants among healthcare workers of a COVID-19 dedicated hospital of India
Mala Mahto, Ayan Banerjee, Bijit Biswas, Sushil Kumar, Neeraj Agarwal, Prabhat Kumar Singh
Healthcare workers (HCWs) due to their job profile are at utmost risk of contracting severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. Serological survey is an useful tool for vulnerability mapping in an infectious disease pandemic. The aim of the current study was to assess seroprevalence of IgG against SARS-CoV-2 and its determinants among HCWs of a tertiary healthcare facility of India. It was an observational study, cross-sectional in design conducted among
Am J Blood Res 2021;11(1):44-52 have played a role as nurses and doctors by virtue of their professional training likely to be more aware of infection prevention and control (IPC) measures to be taken for contagious disease like COVID-19. Thus, they might have taken more precaution in comparison to the other staffs to get themselves protected from SARS-CoV-2 infection. Similarly, we found place of posting as significant attribute affecting IgG seropositivity among the study subjects as in * data for all the variables were available for 689 study subjects thus it was used for performing logistic regression analysis; ICU: intensive care unit, PPE: personal protective equipment, ILI: influenza like illness, HCQ: hydroxychloroquine, COR: crude odds ratio, AOR: adjusted odds ratio, CI: confidence interval. Am J Blood Res 2021;11(1):44-52 involved in the study. Without their unconditional support the study would not have been possible. We received no additional fund for the study. The institutional fund as part of healthcare workers health policy was utilised for this study. Disclosure of conflict of interest None. Address correspondence to: Dr. Bijit Biswas, Department of Community and Family Medicine, All India Institute of Medical Sciences, Phulwarisharif, Patna 801507, Bihar, India. Tel: +917003881125; E-mail:
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