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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Mortality 4% Improvement Relative Risk Improvement in viral load.. 71% c19hcq.org Lyngbakken et al. NCT04316377 HCQ RCT LATE TREATMENT Favors HCQ Favors control
A pragmatic randomized controlled trial reports lack of efficacy of hydroxychloroquine on coronavirus disease 2019 viral kinetics
Lyngbakken et al., Nature Communications, doi:10.1038/s41467-020-19056-6, NCT04316377 (history)
17 Jul 2020    Source   PDF   Share   Tweet
Small RCT of nasopharyngeal viral load not showing significant differences. The rate of reduction for HCQ was 0.24 [0.03-0.46] RNA copies/mL/24h, and 0.14 [-0.10-0.37] for the control group (71% faster with HCQ but not statistically significant with the small sample size of 27 HCQ and 26 control patients). Analysis only over 96 hours. NCT04316377 (history).
risk of death, 3.7% lower, RR 0.96, p = 1.00, treatment 1 of 27 (3.7%), control 1 of 26 (3.8%), NNT 702.
improvement in viral load reduction rate, 71.0% lower, relative rate 0.29, p = 0.51, treatment 27, control 26.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Lyngbakken et al., 17 Jul 2020, Randomized Controlled Trial, Norway, peer-reviewed, median age 62.0, 11 authors, average treatment delay 8.0 days, trial NCT04316377 (history).
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