A pragmatic randomized controlled trial reports lack of efficacy of hydroxychloroquine on coronavirus disease 2019 viral kinetics

{ 'indexed': {'date-parts': [[2024, 3, 29]], 'date-time': '2024-03-29T15:53:45Z', 'timestamp': 1711727625334}, 'reference-count': 18, 'publisher': 'Springer Science and Business Media LLC', 'issue': '1', 'license': [ { 'start': { 'date-parts': [[2020, 10, 20]], 'date-time': '2020-10-20T00:00:00Z', 'timestamp': 1603152000000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}, { 'start': { 'date-parts': [[2020, 10, 20]], 'date-time': '2020-10-20T00:00:00Z', 'timestamp': 1603152000000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}], 'content-domain': {'domain': ['link.springer.com'], 'crossmark-restriction': False}, 'abstract': '<jats:title>Abstract</jats:title><jats:p>Here, we randomized 53 patients hospitalized with ' 'coronavirus disease 2019 (COVID-19) to hydroxychloroquine therapy (at a dose of 400\u2009mg ' 'twice daily for seven days) in addition to standard care or standard care alone ' '(ClinicalTrials.gov Identifier, NCT04316377). All severe acute respiratory syndrome ' 'coronavirus 2 (SARS-CoV-2) positive patients 18 years of age or older were eligible for study ' 'inclusion if they had moderately severe COVID-19 at admission. Treatment with ' 'hydroxychloroquine did not result in a significantly greater rate of decline in SARS-CoV-2 ' 'oropharyngeal viral load compared to standard care alone during the first five days. Our ' 'results suggest no important antiviral effect of hydroxychloroquine in humans infected with ' 'SARS-CoV-2.</jats:p>', 'DOI': '10.1038/s41467-020-19056-6', 'type': 'journal-article', 'created': { 'date-parts': [[2020, 10, 20]], 'date-time': '2020-10-20T10:03:16Z', 'timestamp': 1603188196000}, 'update-policy': 'http://dx.doi.org/10.1007/springer_crossmark_policy', 'source': 'Crossref', 'is-referenced-by-count': 58, 'title': 'A pragmatic randomized controlled trial reports lack of efficacy of hydroxychloroquine on ' 'coronavirus disease 2019 viral kinetics', 'prefix': '10.1038', 'volume': '11', 'author': [ { 'ORCID': 'http://orcid.org/0000-0002-5994-9304', 'authenticated-orcid': False, 'given': 'Magnus Nakrem', 'family': 'Lyngbakken', 'sequence': 'first', 'affiliation': []}, {'given': 'Jan-Erik', 'family': 'Berdal', 'sequence': 'additional', 'affiliation': []}, {'given': 'Arne', 'family': 'Eskesen', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0001-6410-2530', 'authenticated-orcid': False, 'given': 'Dag', 'family': 'Kvale', 'sequence': 'additional', 'affiliation': []}, {'given': 'Inge Christoffer', 'family': 'Olsen', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0003-3720-4659', 'authenticated-orcid': False, 'given': 'Corina Silvia', 'family': 'Rueegg', 'sequence': 'additional', 'affiliation': []}, {'given': 'Anbjørg', 'family': 'Rangberg', 'sequence': 'additional', 'affiliation': []}, { 'given': 'Christine Monceyron', 'family': 'Jonassen', 'sequence': 'additional', 'affiliation': []}, {'given': 'Torbjørn', 'family': 'Omland', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0003-2114-3134', 'authenticated-orcid': False, 'given': 'Helge', 'family': 'Røsjø', 'sequence': 'additional', 'affiliation': []}, {'given': 'Olav', 'family': 'Dalgard', 'sequence': 'additional', 'affiliation': []}], 'member': '297', 'published-online': {'date-parts': [[2020, 10, 20]]}, 'reference': [ { 'key': '19056_CR1', 'doi-asserted-by': 'publisher', 'first-page': '269', 'DOI': '10.1038/s41422-020-0282-0', 'volume': '30', 'author': 'M Wang', 'year': '2020', 'unstructured': 'Wang, M. et al. 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