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COVID-19 in patients with lung cancer

Luo et al., Annals of Oncology, 31:10, 1386-1396, doi:10.1016/j.annonc.2020.06.007
Jun 2020  
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Mortality -2% Improvement Relative Risk HCQ for COVID-19  Luo et al.  LATE TREATMENT Is late treatment with HCQ beneficial for COVID-19? Retrospective 48 patients in the USA Study underpowered to detect differences Luo et al., Annals of Oncology, 1386-1.., Jun 2020 FavorsHCQ Favorscontrol 0 0.5 1 1.5 2+
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
*, now with p < 0.00000000001 from 411 studies, recognized in 46 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 75 treatments.
Analysis of hospitalized lung cancer patients with 35 of 48 taking HCQ, mortality OR 1.03, p = 0.99.
This study is excluded in the after exclusion results of meta analysis: substantial unadjusted confounding by indication likely.
risk of death, 2.2% higher, RR 1.02, p = 0.99, treatment 11 of 35 (31.4%), control 4 of 13 (30.8%), odds ratio converted to relative risk.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Luo et al., 17 Jun 2020, retrospective, USA, peer-reviewed, 31 authors.
This PaperHCQAll
Vitamin D Deficiency Is Inversely Associated with COVID-19 Incidence and Disease Severity in Chinese People
Xia Luo, Qing Liao, Ying Shen, Huijun Li, Liming Cheng
Background: Vitamin D might have beneficial potential in influencing the natural history of the coronavirus disease 2019 (COVID-19) due to its immunomodulatory and anti-inflammatory properties. Objective: The aim was to investigate whether vitamin D deficiency is associated with COVID-19 incidence and disease severity in Chinese people. Methods : In a cross-sectional study we retrospectively analyzed 335 COVID-19 patients (median: 56.0; IQR: 43.0-64.0 y) who were admitted to the Wuhan Tongji Hospital between 27 February and 21 March 2020. We also included an age-and sex-matched population of 560 individuals (median: 55; IQR: 49.0-60.0 y) who underwent the physical examination program. Their serum 25-hydroxyvitamin D [25(OH)D] concentrations were measured during the same period from 2018-2019. Serum 25(OH)D concentrations were measured for all COVID-19 patients on admission. Severity of COVID-19 was determined based on the level of respiratory involvement. A general linear model with adjustment for covariates was used to compare 25(OH)D concentrations between the COVID-19 and 2018-2019 control groups. Adjusted ORs with 95% CIs for associations between vitamin D status and COVID-19 severity were estimated via multivariable logistic regression. Results: In the general linear model adjusted for age, sex, comorbidities, and BMI, serum 25(OH)D concentrations were significantly lower among COVID-19 patients than the 2018-2019 controls [ln transformed values of 3.32 ± 0.04 vs. 3.46 ± 0.022 ln (nmol/L), P = 0.014]. Multivariable logistic regression showed that male sex (OR: 2.26; 95% CI: 1.06, 4.82), advanced age (≥65 y) (OR: 4.93; 95% CI: 1.44, 16.9), and vitamin D deficiency (<30 nmol/L) (OR: 2.72; 95% CI: 1.23, 6.01) were significantly associated with COVID-19 severity (all P < 0.05). Conclusions: These findings suggested that vitamin D deficiency impacts COVID-19 hospitalization and severity in the Chinese population.
Fisher's exact test. 3 Information on BMI was available for 45 cases in the discharged group and 4 in the death group. 4 Including hypertension, diabetes, cardiovascular disease, cerebrovascular disease, chronic lung diseases, chronic kidney disease, and tumors. 5 Serum 25(OH)D concentrations <30 nmol/L. 6 Serum 25(OH)D concentrations ≥30 nmol/L.
Arnold, COVID-19-does this disease kill due to imbalance of the renin angiotensin system (RAS) caused by genetic and gender differences in the response to viral ACE 2 attack?, Heart Lung Circ
Aygun, Vitamin D can prevent COVID-19 infection-induced multiple organ damage, Naunyn Schmiedebergs Arch Pharmacol
Beard, Bearden, Striker, Vitamin D and the anti-viral state, J Clin Virol
D'avolio, Avataneo, Manca, Cusato, Nicolo et al., 25-Hydroxyvitamin D concentrations are lower in patients with positive PCR for SARS-CoV-2, Nutrients
Garcia-Carrasco, Jimenez-Herrera, Galvez-Romero, Mendoza-Pinto, Mendez-Martinez et al., The anti-thrombotic effects of vitamin D and their possible relationship with antiphospholipid syndrome, Lupus
Grant, Lahore, Mcdonnell, Baggerly, French et al., Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths, Nutrients
Hastie, Mackay, Ho, Celis-Morales, Katikireddi et al., Vitamin D concentrations and COVID-19 infection in UK Biobank, Diabetes Metab Syndr
Hoe, Nathanielsz, Toh, Spry, Marimla et al., Anti-inflammatory effects of vitamin D on human immune cells in the context of bacterial infection, Nutrients
Holick, Vitamin D deficiency, N Engl J Med
Hooper, Nápoles, Pérez-Stable, COVID-19 and racial/ethnic disparities, JAMA
Kara, Ekiz, Ricci, Kara, Chang et al., Scientific strabismus" or two related pandemics: coronavirus disease and vitamin D deficiency, Br J Nutr
Levey, Stevens, Schmid, Zhang, Castro Af 3rd et al., A new equation to estimate glomerular filtration rate, Ann Intern Med
Martineau, Jolliffe, Hooper, Greenberg, Aloia et al., Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data, BMJ
Meftahi, Jangravi, Sahraei, Bahari, The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of "inflame-aging, Inflamm Res
Meltzer, Best, Zhang, Vokes, Arora et al., Association of vitamin D deficiency and treatment with COVID-19 incidence. medRxiv, doi:10.1101/2020.05.08.20095893
Merzon, Tworowski, Gorohovski, Vinker, Cohen et al., Low plasma 25(OH) vitamin D level is associated with increased risk of COVID-19 infection: an Israeli population-based study, FEBS J
Nair, Maseeh, Vitamin D: the "sunshine" vitamin, J Pharmacol Pharmacother
Radujkovic, Hippchen, Tiwari-Heckler, Dreher, Boxberger, Vitamin D deficiency and outcome of COVID-19 patients, Nutrients
Rhodes, Subramanian, Laird, Kenny, Editorial: low population mortality from COVID-19 in countries south of latitude 35 degrees north supports vitamin D as a factor determining severity, Aliment Pharmacol Ther
Schwalfenberg, A review of the critical role of vitamin D in the functioning of the immune system and the clinical implications of vitamin D deficiency, Mol Nutr Food Res
Science, Maguire, Russell, Smieja, Walter et al., Low serum 25-hydroxyvitamin D level and risk of upper respiratory tract infection in children and adolescents, Infect Dis
Teymoori-Rad, Shokri, Salimi, Marashi, The interplay between vitamin D and viral infections, Rev Med Virol
Verdoia, Pergolini, Nardin, Rolla, Negro et al., Vitamin D levels and platelet reactivity in diabetic patients receiving dual antiplatelet therapy, Vasc Pharmacol
Wang, Li, Yin, Zhang, Olsen et al., Vitamin D and chronic diseases, Aging Dis
Watkins, Lemonovich, Salata, An update on the association of vitamin D deficiency with common infectious diseases, Can J Physiol Pharmacol
Weiss, Murdoch, Clinical course and mortality risk of severe COVID-19, Lancet North Am Ed
Wong, Chan, Chan, Tse, Chim et al., Adverse effects of vitamin D deficiency on outcomes of patients with chronic hepatitis B, Clin Gastroenterol Hepatol
Xu, Yang, Chen, Luo, Zhang et al., Vitamin D alleviates lipopolysaccharide-induced acute lung injury via regulation of the reninangiotensin system, Mol Med Rep
Zhang, Wu, Sun, Vitamin D, vitamin D receptor, and tissue barriers, Tissue Barriers
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Late treatment
is less effective
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