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Early Lopinavir/ritonavir does not reduce mortality in COVID-19 patients: results of a large multicenter study

Lora-Tamayo et al., Journal of Infection, doi:10.1016/j.jinf.2021.02.011
Feb 2021  
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Mortality 50% Improvement Relative Risk HCQ for COVID-19  Lora-Tamayo et al.  LATE TREATMENT Is late treatment with HCQ beneficial for COVID-19? Retrospective 8,553 patients in Spain Lower mortality with HCQ (p<0.000001) c19hcq.org Lora-Tamayo et al., J. Infection, February 2021 FavorsHCQ Favorscontrol 0 0.5 1 1.5 2+
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020, now with p < 0.00000000001 from 419 studies, recognized in 46 countries.
No treatment is 100% effective. Protocols combine treatments.
5,100+ studies for 112 treatments. c19hcq.org
Lopinavir/ritonavir retrospective study also showing univariate results for HCQ, with significantly lower mortality.
risk of death, 50.5% lower, RR 0.50, p < 0.001, treatment 7,192, control 1,361, odds ratio converted to relative risk, univariate, control prevalence approximated with overall prevalence.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Lora-Tamayo et al., 11 Feb 2021, retrospective, Spain, peer-reviewed, 10 authors.
This PaperHCQAll
Short durations of corticosteroids for hospitalised COVID-19 patients are associated with a high readmission rate
Zain Chaudhry, Marianne Shawe-Taylor, Tommy Rampling, Tim Cutfield, Gabriella Bidwell, Xin Hui S Chan, Anna Last, Bryan Williams, Sarah Logan, Michael Marks, Hanif Esmail
Journal of Infection, doi:10.1016/j.jinf.2021.03.002
Oral corticoid, aspirin, anticoagulant, colchicine, and furosemide to improve the outcome of hospitalized COVID-19 patients -the COCAA-COLA cohort study Dear Editor,
Supplementary materials Supplementary material associated with this article can be found, in the online version, at doi:10.1016/j.jinf.2021.03.002 . Author contributions Haiyan Ethical statement Patient screening and case reviews were undertaken as part of routine infection control in the hospital. Ethics Ethical approval was not required for this service evaluation and audit of practice. Authors' contributions SD, AR and NM designed the study methodology. SD, TE and XG collated the data. SD drafted the initial manuscript with all authors contributing significantly to revising this for submission. All authors agreed on the final version for submission to the journal. Supplementary materials Supplementary material associated with this article can be found, in the online version, at doi:10.1016/j.jinf.2021.02.011 . Appendix List of the SEMI-COVID-19 network members Coordinator of the SEMI- COVID-19 Consent for publication All the authors agree to publish. Declaration of Competing Interest The authors declare that they have no competing interests. Declaration of Competing Interest The authors declare no conflict of interest Rapid whole-genome sequencing to inform COVID-19 outbreak response in Vietnam Dear Editor, The emergence of new SARS-CoV-2 variants, especially those of concerns, and their rapid dispersal emphasize the importance of active surveillance for SARS-CoV-2 variants worldwide. 1 , 2 In the morning of 28th January 2021, after 55 days..
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Late treatment
is less effective
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