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All Studies   Meta Analysis    Recent:   

Factors affecting different COVID-19 outcomes in patients with systemic lupus erythematosus during the second pandemic wave of COVID-19 in China

Feb 2024  
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Severe case 39% Improvement Relative Risk HCQ for COVID-19  Liu et al.  Prophylaxis Is pre-exposure prophylaxis with HCQ beneficial for COVID-19? Retrospective 301 patients in China (December 2022 - February 2023) Lower severe cases with HCQ (not stat. sig., p=0.26) c19hcq.org Liu et al., Lupus, February 2024 FavorsHCQ Favorscontrol 0 0.5 1 1.5 2+
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now with p < 0.00000000001 from 411 studies, recognized in 46 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 75 treatments. c19hcq.org
Retrospective 301 consecutive SLE patients with COVID-19, showing lower risk of severe outcomes with HCQ use, with statistical significance in multivariable adjusted model 1 but not model 2.
risk of severe case, 39.0% lower, OR 0.61, p = 0.26, treatment 55, control 246, adjusted per study, multivariable, model 2, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Liu et al., 5 Feb 2024, retrospective, China, peer-reviewed, 6 authors, study period December 2022 - February 2023.
This PaperHCQAll
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' '</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p> In this retrospective ' 'study, people with SLE and COVID-19 who visited the First Affiliated Hospital of Nanchang ' 'University from December 2022 and February 2023 were subjected to this study. The three ' 'possible outcomes were listed in order of ordinal severity: (1) not hospitalized, (2) ' 'hospitalized but not receiving oxygenation, and (3) hospitalized with any ventilation or ' 'oxygenation. A multivariable ordinal logistic regression model was built to examine the ' 'association between COVID-19 severity and demographic traits, medications, comorbidities, and ' 'disease activity. Furthermore, among the 301 SLE patients included in our study, only two ' 'patients experienced mortality. In order to maintain statistical rigor, we have included ' 'these two deceased patients in the outcome measure of hospitalized with any ventilation or ' 'oxygenation. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> A total ' 'of 301 patients with SLE were enrolled in this study. The multivariate ordinal logistic ' 'regression analyses indicated that high SLE disease activity (vs remission; OR 39.04, 95% CI ' '3.08 to 494.44, p = .005) was associated with more severe outcomes. Three doses of COVID-19 ' 'vaccination (OR 0.19, 95% CI 0.07 to 0.51, p = .001), glucocorticoids dose (1–5\xa0mg/day ' '0.14, 0.03 to 0.73, p = .020, and 6–9\xa0mg/day 0.12, 0.02 to 0.61, p = .010), and more ' 'intensive immunosuppression drugs (0.34, 0.12 to 0.97, p = .044) were associated with better ' 'outcomes. In age-adjusted and sex-adjusted models, telitacicept (6.66, 1.35 to 32.86, p = ' '.020) and rituximab (7.81, 1.87 to 32.66, p = .005) were associated with more severe ' 'outcomes. Hydroxychloroquine (0.47, 0.25 to 0.88, p = .018) was associated with favorable ' 'outcomes. </jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p> Different ' 'COVID-19 outcomes in people with SLE are mostly driven by COVID-19 vaccination, medications, ' 'and activity SLE. More importantly, three doses of COVID-19 vaccination may be associated ' 'with better outcomes. </jats:p></jats:sec>', 'DOI': '10.1177/09612033241230736', 'type': 'journal-article', 'created': {'date-parts': [[2024, 2, 5]], 'date-time': '2024-02-05T11:44:34Z', 'timestamp': 1707133474000}, 'update-policy': 'http://dx.doi.org/10.1177/sage-journals-update-policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Factors affecting different COVID-19 outcomes in patients with systemic lupus erythematosus ' 'during the second pandemic wave of COVID-19 in China', 'prefix': '10.1177', 'author': [ { 'ORCID': 'http://orcid.org/0000-0002-9144-1623', 'authenticated-orcid': False, 'given': 'Peng-Cheng', 'family': 'Liu', 'sequence': 'first', 'affiliation': [ { 'name': 'Department of Rheumatology, The First Affiliated Hospital, ' 'Jiangxi Medical College, Nanchang University, Nanchang, China'}]}, { 'given': 'Min', 'family': 'Zhang', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Rheumatology, The First Affiliated Hospital, ' 'Jiangxi Medical College, Nanchang University, Nanchang, China'}]}, { 'ORCID': 'http://orcid.org/0000-0001-9629-8558', 'authenticated-orcid': False, 'given': 'Jian-Bin', 'family': 'Li', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Rheumatology, The First Affiliated Hospital, ' 'Jiangxi Medical College, Nanchang University, Nanchang, China'}]}, { 'given': 'Yi-Lin', 'family': 'Peng', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Rheumatology, The First Affiliated Hospital, ' 'Jiangxi Medical College, Nanchang University, Nanchang, China'}]}, { 'given': 'Shu-Jiao', 'family': 'Yu', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Rheumatology, The First Affiliated Hospital, ' 'Jiangxi Medical College, Nanchang University, Nanchang, China'}]}, { 'ORCID': 'http://orcid.org/0000-0003-0110-4912', 'authenticated-orcid': False, 'given': 'Rui', 'family': 'Wu', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Rheumatology, The First Affiliated Hospital, ' 'Jiangxi Medical College, Nanchang University, Nanchang, ' 'China'}]}], 'member': '179', 'published-online': {'date-parts': [[2024, 2, 5]]}, 'reference': [ { 'key': 'bibr1-09612033241230736', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/s41586-020-2521-4'}, { 'key': 'bibr2-09612033241230736', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/S2665-9913(20)30227-7'}, { 'key': 'bibr3-09612033241230736', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/S2665-9913(21)00151-X'}, { 'key': 'bibr4-09612033241230736', 'doi-asserted-by': 'publisher', 'DOI': '10.1136/annrheumdis-2020-217763'}, { 'key': 'bibr5-09612033241230736', 'doi-asserted-by': 'publisher', 'DOI': '10.1080/1744666X.2021.1847084'}, { 'key': 'bibr6-09612033241230736', 'doi-asserted-by': 'publisher', 'DOI': '10.1001/jama.2020.12839'}, { 'key': 'bibr7-09612033241230736', 'doi-asserted-by': 'publisher', 'DOI': 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