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0 0.5 1 1.5 2+ Time to viral- -40% Improvement Relative Risk Li et al. HCQ for COVID-19 LATE TREATMENT Is late treatment with HCQ beneficial for COVID-19? Retrospective 37 patients in China Slower viral clearance with HCQ (not stat. sig., p=0.056) Li et al., Research Square, doi:10.21203/ Favors HCQ Favors control
Treatment of COVID-19 patients with hydroxychloroquine or chloroquine: A retrospective analysis
Li et al., Research Square, doi:10.21203/ (Preprint)
Li et al., Treatment of COVID-19 patients with hydroxychloroquine or chloroquine: A retrospective analysis, Research Square, doi:10.21203/ (Preprint)
Jan 2021   Source   PDF  
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Small retrospective database analysis of 37 late stage patients hospitalized in an intensive care center in China, not finding a significant difference in viral shedding. Pateints were all in serious condition. There was only one death however the group is not specified. Confounding by indication is likely.
time to viral-, 40.0% higher, relative time 1.40, p = 0.06, treatment 18, control 19.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Li et al., 12 Jan 2021, retrospective, database analysis, China, preprint, 5 authors.
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Abstract: Treatment of COVID-19 patients with hydroxychloroquine or chloroquine: A retrospective analysis Hui Li Hangzhou Red Cross Hospital Min Deng Hangzhou Red Cross Hospital Jie Wang Hangzhou Red Cross Hospital Lin Ma Hangzhou Red Cross Hospital Zheng Yang (  ) Hangzhou Red Cross Hospital Research Article Keywords: SARS-CoV-2, COVID-19, Hydroxychloroquine, Chloroquine Posted Date: January 12th, 2021 DOI: License:   This work is licensed under a Creative Commons Attribution 4.0 International License. Read Full License Blinded Manuscript Background There is an urgent need for an effective treatment to cure patients with COVID-19 and reduce the duration of viral shedding. Methods We conducted a retrospective study using data from the electronic medical records of patients with confirmed SARS-CoV-2 infection who were hospitalized in the E1-4 intensive care center of Guanggu Hospital, Wuhan City, Hubei Province, China, from February 11, 2020, to March 23, 2020. According to the diagnostic results, the hospitalized patients were divided into the experimental group treated with hydroxychloroquine (HCQ) or chloroquine (CQ) and the control group only treated with conventional therapy without HCQ or CQ. The main outcome was the clearance rate of SARS-CoV-2. Results A total of 37 patients were evaluated. Eighteen patients were assigned to the HCQ or CQ group, and 19 were assigned to the routine treatment group. Treatment with HCQ or CQ was not associated with a difference from routine treatment in the viral shedding duration (median, 14 days vs. 10 days; hazard ratio for viral shedding, 0.393; 95% confidence interval [CI], 0.151 to 1.022; P=0.056). No significant difference in the viral shedding rate was observed between the groups at any time point (7 days, 14 days, 21 days, 28 days and the end point). Conclusion Although this is a retrospective analysis, the results suggest that treatment with HCQ or CQ had no impact on the duration of viral shedding. Keywords: SARS-CoV-2, COVID-19, Hydroxychloroquine, Chloroquine
Late treatment
is less effective
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