Lambermont: Predictors of Mortality and Effect of Drug Therapies in Mechanically Ventilated Patients With Coronavirus Disease 2019: A Multicenter Cohort Study

Predictors of Mortality and Effect of Drug Therapies in Mechanically Ventilated Patients With Coronavirus Disease 2019: A Multicenter Cohort Study

Lambermont et al., Critical Care Explorations, doi:10.1097/CCE.0000000000000305

28 Nov 2020 Source PDF Share Tweet

Retrospective 247 mechanically ventilated patients showing lower mortality with HCQ, but not statistically significant on multiple Cox regression.

The paper gives the p value for multiple Cox (0.46) and simple Cox (0.02), but does not specify the adjusted risk values.

Although the 32% lower mortality is not statistically significant, it is consistent with the significant 22% lower mortality [18‑27%] from meta analysis of the 228 mortality results to date.

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risk of death, 32.3% lower, RR 0.68, p = 0.46, treatment 97 of 225 (43.1%), control 14 of 22 (63.6%), NNT 4.9, adjusted per study.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Lambermont et al., 28 Nov 2020, retrospective, Belgium, peer-reviewed, 15 authors.

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This Paper HCQ All

Late treatment
is less effective

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