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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Mortality 9% Improvement Relative Risk ICU admission -20% Hospitalization time 12% no CI c19hcq.org Lamback et al. HCQ for COVID-19 LATE TREATMENT Favors HCQ Favors control
Hydroxychloroquine with azithromycin in patients hospitalized for mild and moderate COVID-19
Lamback et al., The Brazilian Journal of Infectious Diseases, doi:10.1016/j.bjid.2021.101549
19 Feb 2021    Source   PDF   Share   Tweet
Retrospective 193 hospitalized patients in Brazil not finding a significant difference with HCQ.
The control group was composed of patients refusing HCQ or with contraindications. Time based confounding is very likely because HCQ became more controversial in Brazil over the time covered (Mar - Jun 2020), while overall treatment protocols during this period improved dramatically, i.e., more control patients (those refusing HCQ) likely come later in the period when treatment protocols were greatly improved.
The paper does not mention the word "confounding" or make any adjustments.
risk of death, 8.9% lower, RR 0.91, p = 0.83, treatment 11 of 101 (10.9%), control 11 of 92 (12.0%), NNT 94.
risk of ICU admission, 19.9% higher, RR 1.20, p = 0.61, treatment 25 of 101 (24.8%), control 19 of 92 (20.7%).
hospitalization time, 12.5% lower, relative time 0.88, treatment 101, control 92.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
This study is excluded in the after exclusion results of meta analysis: substantial confounding by time likely due to declining usage over the early stages of the pandemic when overall treatment protocols improved dramatically.
Lamback et al., 19 Feb 2021, retrospective, Brazil, peer-reviewed, 10 authors.
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