Clinical comorbidities, characteristics, and outcomes of mechanically ventilated patients in the State of Michigan with SARS-CoV-2 pneumonia
Krishnan et al.
, Clinical comorbidities, characteristics, and outcomes of mechanically ventilated patients in the State of..
, J Clin Anesth., doi:10.1016/j.jclinane.2020.110005
Retrospective 152 mechanically ventilated patients in the USA showing unadjusted lower mortality with vitamin C, vitamin D, HCQ, and zinc treatment, statistically significant only for vitamin C.
Although the 20% lower mortality is not statistically significant, it is consistent with the significant 22% lower mortality [18‑27%]
from meta analysis of the 232 mortality results to date
This study is excluded in the after exclusion results of meta
unadjusted results with no group details.
risk of death, 20.4% lower, RR 0.80, p = 0.48, treatment 86 of 144 (59.7%), control 6 of 8 (75.0%), NNT 6.5.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Krishnan et al., 20 Jul 2020, retrospective, USA, peer-reviewed, 13 authors, dosage not specified.
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Journal of Clinical Anesthesia 67 (2020) 110005
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Clinical comorbidities, characteristics, and outcomes of mechanically ventilated patients in the
State of Michigan with SARS-CoV-2 pneumonia
In December 2019, a series of viral infections, eventually named
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) appeared in China and quickly spread across the world . The United
States (USA) has been profoundly affected, reporting the most confirmed cases of SARS-CoV-2 of any country. As of June 10, 2020, SARSCoV-2 infection has been confirmed in more than 7.3 million individuals in 188 countries and regions, with an overall mortality rate of
more than 5.7% . The State of Michigan has been particularly devastated by this disease; it ranks 9th in the USA with 65,182 total
confirmed cases of SARS-CoV-2 and 6th in the USA with 5955 total
deaths . While the clinical course of patients with SARS-CoV-2 infection can vary from completely asymptomatic to critically ill, an
understanding of differing patient characteristics and outcomes of infected patients is critical for health and government officials engaged in
planning efforts to address outbreaks. We sought to describe the demographics, baseline comorbidities, and outcomes in patients with
SARS-CoV-2 who required mechanical ventilation from a single hospital
system in the state of Michigan, USA.
This retrospective observational study was conducted at St. Joseph
Mercy Oakland Hospital, and data were obtained from medical records
from the 7 hospitals in the health system (1996 beds). The institutional
review board approved the study as minimal-risk research using data
collected for routine clinical practice and waived the requirement for
informed consent. All consecutive patients from March 10, 2020 to
April 15, 2020 who required hospital admission with confirmed SARSCoV-2 infection by positive result on polymerase chain reaction (PCR)
testing of a nasopharyngeal sample were included in this study. The
focus of this study was SARS-CoV-2 patients who required mechanical
ventilation in the Intensive Care Unit (ICU), and only patients who
completed their hospital course within the health system at study end
(discharged alive or dead) were included in the study.
During the study period a total of 901 adult patients with confirmed
SARS-CoV-2 infection were admitted to the 7 hospitals within the
health system. After initial chart review 152 patients requiring mechanical ventilation were included. Of the 152 mechanically ventilated
patients with confirmed SARS-CoV-2 infection, 39% (60)..
is less effective
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