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0 0.5 1 1.5 2+ Case 51% Improvement Relative Risk HCQ for COVID-19  Khurana et al.  Prophylaxis Is pre-exposure prophylaxis with HCQ beneficial for COVID-19? Retrospective 181 patients in India Fewer cases with HCQ (p=0.021) Khurana et al., medRxiv, July 2020 Favors HCQ Favors control

Prevalence and clinical correlates of COVID-19 outbreak among healthcare workers in a tertiary level hospital

Khurana et al., medRxiv, doi:10.1101/2020.07.21.20159301
Jul 2020  
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Study of hospital health care workers showing HCQ prophylaxis reduces COVID-19 significantly, OR 0.30, p=0.02. 94 positive health care workers with a matched sample of 87 testing negative. Full course prophylaxis was important in this study which used a low dose of 400mg/week HCQ (800mg for week 1), so it may take longer to reach therapeutic levels. Actual benefit of HCQ may be larger because severity of symptoms are not considered here but HCQ may also reduce severity.
risk of case, 51.0% lower, RR 0.49, p = 0.02, treatment 6 of 22 (27.3%), control 88 of 159 (55.3%), NNT 3.6, odds ratio converted to relative risk.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Khurana et al., 24 Jul 2020, retrospective, India, preprint, survey, 5 authors.
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Prevalence and clinical correlates of COVID-19 outbreak among health care workers in a tertiary level hospital in Delhi
Dr Ankit Khurana, G P Kaushal, Rishi Gupta, Vansh Verma, Kabir Sharma, Manmohan Kohli
In this study, we summarize the epidemiological characteristics of COVID-19 outbreak among Healthcare workers (HCWs) in a tertiary care hospital and compared various parameters and preventive measures taken by positive HCWs to a comparable cohort of COVID negative HCWs. 52.1% of COVID-19 positive HCWs showed symptoms of which only three needed hospitalization possibly due to a younger cohort of HCWs who got infected (35.9 ± 9.3 years). Findings of present study found some protective role of full course prophylactic hydroxychloroquine as compared to a control group (p=0.021) and use of N95 masks over others (p<0.001). Our results did not show any added protection with the use of prophylactic Vitamin C, D, Zinc, or betadine gargles. We also observed outbreak control with increased awareness, near universal testing, PPE provision, sanitization drive, and promoting social distancing among HCWs. .
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