Prevalence and clinical correlates of COVID-19 outbreak among healthcare workers in a tertiary level hospital
Khurana et al.,
Prevalence and clinical correlates of COVID-19 outbreak among healthcare workers in a tertiary level hospital,
medRxiv, doi:10.1101/2020.07.21.20159301 (Preprint)
Study of hospital health care workers showing HCQ prophylaxis reduces COVID-19 significantly, OR 0.30, p=0.02. 94 positive health care workers with a matched sample of 87 testing negative. Full course prophylaxis was important in this study which used a low dose of 400mg/week HCQ (800mg for week 1), so it may take longer to reach therapeutic levels. Actual benefit of HCQ may be larger because severity of symptoms are not considered here but HCQ may also reduce severity.
risk of case, 51.0% lower, RR 0.49, p = 0.02, treatment 6 of 22 (27.3%), control 88 of 159 (55.3%), NNT 3.6, odds ratio converted to relative risk.
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Khurana et al., 24 Jul 2020, retrospective, India, preprint, survey, 5 authors.
Abstract: medRxiv preprint doi: https://doi.org/10.1101/2020.07.21.20159301; this version posted July 24, 2020. The copyright holder for this preprint
(which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
It is made available under a CC-BY-NC-ND 4.0 International license .
Title: Prevalence and clinical correlates of COVID-19 outbreak among health care workers
in a tertiary level hospital in Delhi
Running title: Epidemiology and risk assessment of COVID 19 outbreak among
healthcare workers
Authors:
1. Dr Ankit Khurana (First Author)
Assistant Professor Orthopaedics, Dr. Baba Saheb Ambedkar Medical College and
Hospital, Rohini, Delhi. ankit24388@gmail.com
2. Dr GP Kaushal (Corresponding author)
In- charge Neonatal Unit, Department of Pediatrics Dr. Baba Saheb Ambedkar Medical
College and Hospital, Rohini, Delhi. gpkaushal2005@gmail.com. Postal Address:
Department of Pediatrics, Dr BSA Medical college and hospital, Rohini Sector 6, Delhi110085.
3. Dr Rishi Gupta
Biostatistician, Manokalp clinic Shalimar Bagh Delhi. mailrishigupta@gmail.com
4. Vansh Verma
MBBS student, Dr. Baba Saheb Ambedkar Medical College and Hospital, Rohini,
Delhi. asusvv2017@gmail.com
5. Kabir Sharma
MBBS student, Dr. Baba Saheb Ambedkar Medical College and Hospital, Rohini,
Delhi. Doctorkabirsharma@gmail.com
6. Dr Manmohan Kohli
HOD, Department of Pediatricss, Dr. Baba Saheb Ambedkar Medical college
and
Hospital, Rohini, Delhi. pmkohli@gmail.com
NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice.
medRxiv preprint doi: https://doi.org/10.1101/2020.07.21.20159301; this version posted July 24, 2020. The copyright holder for this preprint
(which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
It is made available under a CC-BY-NC-ND 4.0 International license .
Abstract: In this study, we summarize the epidemiological characteristics of COVID-19 outbreak
among Healthcare workers (HCWs) in a tertiary care hospital and compared various parameters and
preventive measures taken by positive HCWs to a comparable cohort of COVID negative HCWs.
52.1% of COVID-19 positive HCWs showed symptoms of which only three needed hospitalization
possibly due to a younger cohort of HCWs who got infected (35.9 ± 9.3 years). Findings of present
study found some protective role of full course prophylactic hydroxychloroquine as compared to a
control group (p=0.021) and use of N95 masks over others (p<0.001). Our results did not show any
added protection with the use of prophylactic Vitamin C, D, Zinc, or betadine gargles. We also
observed outbreak control with increased awareness, near universal testing, PPE provision,
sanitization drive, and promoting social distancing among HCWs.
medRxiv preprint doi: https://doi.org/10.1101/2020.07.21.20159301; this version posted July 24, 2020. The copyright holder for this preprint
(which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
It is made available under a CC-BY-NC-ND 4.0 International license .
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