Abstract: medRxiv preprint doi: https://doi.org/10.1101/2020.07.21.20159301; this version posted July 24, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license . Title: Prevalence and clinical correlates of COVID-19 outbreak among health care workers in a tertiary level hospital in Delhi Running title: Epidemiology and risk assessment of COVID 19 outbreak among healthcare workers Authors: 1. Dr Ankit Khurana (First Author) Assistant Professor Orthopaedics, Dr. Baba Saheb Ambedkar Medical College and Hospital, Rohini, Delhi. ankit24388@gmail.com 2. Dr GP Kaushal (Corresponding author) In- charge Neonatal Unit, Department of Pediatrics Dr. Baba Saheb Ambedkar Medical College and Hospital, Rohini, Delhi. gpkaushal2005@gmail.com. Postal Address: Department of Pediatrics, Dr BSA Medical college and hospital, Rohini Sector 6, Delhi110085. 3. Dr Rishi Gupta Biostatistician, Manokalp clinic Shalimar Bagh Delhi. mailrishigupta@gmail.com 4. Vansh Verma MBBS student, Dr. Baba Saheb Ambedkar Medical College and Hospital, Rohini, Delhi. asusvv2017@gmail.com 5. Kabir Sharma MBBS student, Dr. Baba Saheb Ambedkar Medical College and Hospital, Rohini, Delhi. Doctorkabirsharma@gmail.com 6. Dr Manmohan Kohli HOD, Department of Pediatricss, Dr. Baba Saheb Ambedkar Medical college and Hospital, Rohini, Delhi. pmkohli@gmail.com NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice. medRxiv preprint doi: https://doi.org/10.1101/2020.07.21.20159301; this version posted July 24, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license . Abstract: In this study, we summarize the epidemiological characteristics of COVID-19 outbreak among Healthcare workers (HCWs) in a tertiary care hospital and compared various parameters and preventive measures taken by positive HCWs to a comparable cohort of COVID negative HCWs. 52.1% of COVID-19 positive HCWs showed symptoms of which only three needed hospitalization possibly due to a younger cohort of HCWs who got infected (35.9 ± 9.3 years). Findings of present study found some protective role of full course prophylactic hydroxychloroquine as compared to a control group (p=0.021) and use of N95 masks over others (p<0.001). Our results did not show any added protection with the use of prophylactic Vitamin C, D, Zinc, or betadine gargles. We also observed outbreak control with increased awareness, near universal testing, PPE provision, sanitization drive, and promoting social distancing among HCWs. medRxiv preprint doi: https://doi.org/10.1101/2020.07.21.20159301; this version posted July 24, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license .