Hydroxychloroquine pre-exposure prophylaxis provides no protection against COVID-19 among health care workers: a cross-sectional study in a tertiary care hospital in North India

{ 'indexed': {'date-parts': [[2022, 1, 8]], 'date-time': '2022-01-08T05:59:36Z', 'timestamp': 1641621576398}, 'reference-count': 14, 'publisher': 'Walter de Gruyter GmbH', 'issue': '0', 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'short-container-title': [], 'abstract': '<jats:title>Abstract</jats:title>\n' ' <jats:sec id="j_jbcpp-2021-0221_abs_001">\n' ' <jats:title>Objectives</jats:title>\n' ' <jats:p>The use of Hydroxychloroquine (HCQ) prophylaxis has been ' 'recommended by the National task force constituted by the Indian Council of Medical Research ' '(ICMR) for the prevention of corona virus disease 2019 (COVID-19) among healthcare workers ' '(HCWs). However, this recommendation was based essentially on the preclinical data and ' 'limited clinical experience. The aim of this study was to evaluate the efficacy and safety of ' 'HCQ as a pre-exposure prophylaxis for COVID-19 infection among Indian HCWs.</jats:p>\n' ' </jats:sec>\n' ' <jats:sec id="j_jbcpp-2021-0221_abs_003">\n' ' <jats:title>Methods</jats:title>\n' ' <jats:p>A cross-sectional study was conducted among HCWs of a tertiary care ' 'hospital in north India. The HCQ prophylaxis was initiated among 996 HCWs and they were ' 'followed up to 8\xa0weeks for conversion to COVID-19 positive status and any adverse drug ' 'reaction (ADR).</jats:p>\n' ' </jats:sec>\n' ' <jats:sec id="j_jbcpp-2021-0221_abs_004">\n' ' <jats:title>Results</jats:title>\n' ' <jats:p>About 10.3% of the study participants were tested positive for ' 'COVID-19 which was comparable to the positivity rate among HCWs not taking HCQ prophylaxis ' '(9.7%).</jats:p>\n' ' </jats:sec>\n' ' <jats:sec id="j_jbcpp-2021-0221_abs_005">\n' ' <jats:title>Conclusions</jats:title>\n' ' <jats:p>HCQ was well tolerated at a weekly dose of 400\xa0mg for 8\xa0weeks ' 'but provided no additional benefit in prevention of COVID-19 among HCWs.</jats:p>\n' ' </jats:sec>', 'DOI': '10.1515/jbcpp-2021-0221', 'type': 'journal-article', 'created': {'date-parts': [[2022, 1, 7]], 'date-time': '2022-01-07T08:28:48Z', 'timestamp': 1641544128000}, 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': [ 'Hydroxychloroquine pre-exposure prophylaxis provides no protection against COVID-19 among ' 'health care workers: a cross-sectional study in a tertiary care hospital in North India'], 'prefix': '10.1515', 'volume': '0', 'author': [ { 'given': 'Shivani', 'family': 'Juneja', 'sequence': 'first', 'affiliation': [ { 'name': 'Department of Clinical Pharmacology , Fortis Hospital Mohali , ' 'Mohali , India'}]}, { 'given': 'Proteesh', 'family': 'Rana', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Pharmacology, University College of Medical ' 'Sciences , Delhi , India'}]}, { 'given': 'Parvinder', 'family': 'Chawala', 'sequence': 'additional', 'affiliation': [{'name': 'Fortis Hospital Mohali , Mohali , Punjab , India'}]}, { 'given': 'Rekha', 'family': 'Katoch', 'sequence': 'additional', 'affiliation': [{'name': 'Fortis Hospital Mohali , Mohali , Punjab , India'}]}, { 'given': 'Kulvir', 'family': 'Singh', 'sequence': 'additional', 'affiliation': [{'name': 'Fortis Hospital Mohali , Mohali , Punjab , India'}]}, { 'given': 'Shobha', 'family': 'Rana', 'sequence': 'additional', 'affiliation': [{'name': 'Fortis Hospital Mohali , Mohali , Punjab , India'}]}, { 'given': 'Tamanna', 'family': 'Mittal', 'sequence': 'additional', 'affiliation': [{'name': 'Fortis Hospital Mohali , Mohali , Punjab , India'}]}, { 'given': 'Bhavnish', 'family': 'Kaur', 'sequence': 'additional', 'affiliation': [{'name': 'Fortis Hospital Mohali , Mohali , Punjab , India'}]}, { 'given': 'Simaranjot', 'family': 'Kaur', 'sequence': 'additional', 'affiliation': [{'name': 'Fortis Hospital Mohali , Mohali , Punjab , India'}]}], 'member': '374', 'published-online': {'date-parts': [[2022, 1, 7]]}, 'reference': [ { 'key': '2022010717003844546_j_jbcpp-2021-0221_ref_001', 'unstructured': 'COVID19 state wise status. Government of India. Available from: ' 'https://www.mygov.in/corona-data/covid19-statewise-status [Accessed 27 ' 'Jun 2020].'}, { 'key': '2022010717003844546_j_jbcpp-2021-0221_ref_002', 'unstructured': 'Recommendation for empiric use of hydroxy-chloroquine for prophylaxis of ' 'SARS-CoV-2. Indian Council for Medical Research 2020. Available from: ' 'https://icmr.nic.in/sites/default/files/upload_documents/HCQ_Recommendation_22March_final_MM_V2.pdf ' '[Accessed 24 Apr 2020].'}, { 'key': '2022010717003844546_j_jbcpp-2021-0221_ref_003', 'doi-asserted-by': 'crossref', 'unstructured': 'Gio, J, Tian, Z, Yang, X. Breakthrough: chloroquine phosphate has\xa0' 'shown apparent efficacy in treatment of COVID-19 associated pneumonia in ' 'clinical studies. Biosci Trends 2020;14:72–3.', 'DOI': '10.5582/bst.2020.01047'}, { 'key': '2022010717003844546_j_jbcpp-2021-0221_ref_004', 'unstructured': 'Revised advisory on the use of Hydroxychloroquine (HCQ) as\xa0' 'prophylaxis for COVID-19 infection. Available from: ' 'https://www.mohfw.gov.in/pdf/RevisedadvisoryontheuseofhydroxychloroquineasprophylaxisforSARSCOVID19infection.pdf ' '[Accessed 24 Apr 2020].'}, { 'key': '2022010717003844546_j_jbcpp-2021-0221_ref_005', 'doi-asserted-by': 'crossref', 'unstructured': 'Ferner, RE, Aronson, JK. Chloroquine and hydroxychloroquine in COVID-19. ' 'BMJ 2020;369:1432. https://doi.org/10.1136/bmj.m1432.', 'DOI': '10.1136/bmj.m1432'}, { 'key': '2022010717003844546_j_jbcpp-2021-0221_ref_006', 'doi-asserted-by': 'crossref', 'unstructured': 'Hartwig, SC, Siegel, J, Schneider, PJ. Preventability and severity ' 'assessment in reporting adverse drug reactions. Am J Hosp Pharm ' '1992;49:2229–32. https://doi.org/10.1093/ajhp/49.9.2229.', 'DOI': '10.1093/ajhp/49.9.2229'}, { 'key': '2022010717003844546_j_jbcpp-2021-0221_ref_007', 'unstructured': 'World Health Organization (WHO). Uppsala Monitoring Centre. The use of ' 'the WHO-UMC system for standardized case causality assessment. WHO. ' 'Available from: http://www.who-umc.org/graphics/4409.pdf [Accessed 24 ' 'Jun 2021].'}, { 'key': '2022010717003844546_j_jbcpp-2021-0221_ref_008', 'doi-asserted-by': 'crossref', 'unstructured': 'Abella, BS, Jolkovsky, EL, Biney, BT, Uspal, JE, Hyman, MC, Frank, I, et ' 'al.. Prevention and treatment of COVID-19 with hydroxychloroquine ' '(PATCH) investigators. Efficacy and safety of hydroxychloroquine vs ' 'placebo for pre-exposure SARS-CoV-2 prophylaxis among health care ' 'workers: a randomized clinical trial. JAMA Intern Med 2021;181:195–202. ' 'https://doi.org/10.1001/jamainternmed.2020.6319.', 'DOI': '10.1001/jamainternmed.2020.6319'}, { 'key': '2022010717003844546_j_jbcpp-2021-0221_ref_009', 'doi-asserted-by': 'crossref', 'unstructured': 'Boulware, DR, Pullen, MF, Bangdiwala, AS, Pastick, KA, Lofgren, SM, ' 'Okafor, EC, et al.. A randomized trial of hydroxychloroquine as ' 'postexposure prophylaxis for COVID-19. N Engl J Med 2020;383:517–25. ' 'https://doi.org/10.1056/nejmoa2016638.', 'DOI': '10.1056/NEJMoa2016638'}, { 'key': '2022010717003844546_j_jbcpp-2021-0221_ref_010', 'unstructured': 'Bhattacharyya, D, Raizada, N, Nagappa, B, Tomar, A, Maurya, P, ' 'Chaudhary, A, et al.. Chemoprophylaxis of COVID-19 with ' 'hydroxychloroquine: a study of health care workers attitude, adherence ' 'to regime and side effects. Available from: ' 'https://www.medrxiv.org/content/10.1101/2020.06.11.20126359v1 [Accessed ' '20 Jun 2020].'}, { 'key': '2022010717003844546_j_jbcpp-2021-0221_ref_011', 'doi-asserted-by': 'crossref', 'unstructured': 'Rana, P, Ghadlinge, M, Singh, P, Chandane, R, Khanna, A. Assessment of ' 'knowledge, attitude and practices on the use of hydroxychloroquine (HCQ) ' 'as prophylaxis for COVID-19 infection among medical doctors: a ' 'cross-sectional study. Pharm Biomed Res 2021;7:97–104.', 'DOI': '10.18502/pbr.v7i2.7362'}, { 'key': '2022010717003844546_j_jbcpp-2021-0221_ref_012', 'doi-asserted-by': 'crossref', 'unstructured': 'Jha, S, Batra, N, Siddiqui, S, Yadav, A, Misra, A, Loomba, M, et al.. ' 'HCQ prophylaxis in COVID-19 did not show any QTc prolongation in ' 'Healthcare workers. Indian Heart J 2021;73:74–6. ' 'https://doi.org/10.1016/j.ihj.2020.11.005.', 'DOI': '10.1016/j.ihj.2020.11.005'}, { 'key': '2022010717003844546_j_jbcpp-2021-0221_ref_013', 'doi-asserted-by': 'crossref', 'unstructured': 'Toumi, M, Biernikiewicz, M, Liang, S, Wang, Y, Qiu, T, Han, R. A\xa0' 'critical analysis and review of Lancet COVID-19 hydroxychloroquine ' 'study. J Mark Access Health Policy 2020;8:1809236. ' 'https://doi.org/10.1080/20016689.2020.1809236.', 'DOI': '10.1080/20016689.2020.1809236'}, { 'key': '2022010717003844546_j_jbcpp-2021-0221_ref_014', 'doi-asserted-by': 'crossref', 'unstructured': 'Chen, Y, Li, MX, Lu, GD, Shen, HM, Zhou, J. ' 'Hydroxychloroquine/Chloroquine as therapeutics for COVID-19: truth under ' 'the mystery. Int J Biol Sci 2021;17:1538–46. ' 'https://doi.org/10.7150/ijbs.59547.', 'DOI': '10.7150/ijbs.59547'}], 'container-title': ['Journal of Basic and Clinical Physiology and Pharmacology'], 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://www.degruyter.com/document/doi/10.1515/jbcpp-2021-0221/xml', 'content-type': 'application/xml', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://www.degruyter.com/document/doi/10.1515/jbcpp-2021-0221/pdf', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2022, 1, 7]], 'date-time': '2022-01-07T17:01:05Z', 'timestamp': 1641574865000}, 'score': 1, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2022, 1, 7]]}, 'references-count': 14, 'journal-issue': {'issue': '0', 'published-online': {'date-parts': [[2022, 1, 7]]}}, 'alternative-id': ['10.1515/jbcpp-2021-0221'], 'URL': 'http://dx.doi.org/10.1515/jbcpp-2021-0221', 'relation': {}, 'ISSN': ['0792-6855', '2191-0286'], 'issn-type': [{'value': '0792-6855', 'type': 'print'}, {'value': '2191-0286', 'type': 'electronic'}], 'subject': ['Drug Discovery', 'Pharmacology', 'General Medicine', 'Physiology'], 'published': {'date-parts': [[2022, 1, 7]]}}