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Countries which Primarily Use Antimalarial Drugs As COVID-19 Treatment See Slower Dynamic of Daily Deaths

Izoulet, M., SSRN, doi:10.2139/ssrn.3575899, Apr 2020
Mortality 85% Improvement Relative Risk HCQ for COVID-19  Izoulet et al.  LATE TREATMENT Is late treatment with HCQ beneficial for COVID-19? Retrospective 1,000,000 patients in multiple countries Lower mortality with HCQ (p=0.001) c19hcq.org Izoulet, M., SSRN, April 2020 FavorsHCQ Favorscontrol 0 0.5 1 1.5 2+
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020, now with p < 0.00000000001 from 423 studies, used in 59 countries.
No treatment is 100% effective. Protocols combine treatments.
5,500+ studies for 121 treatments. c19hcq.org
Compares the dynamics of daily deaths in the 10 days following the 3rd death in countries using and not using [H]CQ, showing dramatically lower death in [H]CQ countries. This paper does not attempt to account for population age and other differences between the countries and recommends further study.
This study is excluded in the after exclusion results of meta analysis: excessive unadjusted differences between groups.
risk of death, 85.0% lower, RR 0.15, p < 0.001.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Izoulet et al., 21 Apr 2020, retrospective, multiple countries, preprint, 1 author, dosage not specified.
Abstract: d Countries which Primarily use Antimalarial Drugs as 5 ev iew e COVID-19 Treatment See Slower Dynamic of daily Deaths Maxime Izoulet, CEMI-EHESS, Paris.
DOI record: { "DOI": "10.2139/ssrn.3575899", "ISSN": [ "1556-5068" ], "URL": "http://dx.doi.org/10.2139/ssrn.3575899", "author": [ { "affiliation": [], "family": "Izoulet", "given": "Maxime", "sequence": "first" } ], "container-title": "SSRN Electronic Journal", "container-title-short": "SSRN Journal", "content-domain": { "crossmark-restriction": false, "domain": [] }, "created": { "date-parts": [ [ 2020, 4, 16 ] ], "date-time": "2020-04-16T11:31:03Z", "timestamp": 1587036663000 }, "deposited": { "date-parts": [ [ 2020, 4, 16 ] ], "date-time": "2020-04-16T11:31:32Z", "timestamp": 1587036692000 }, "indexed": { "date-parts": [ [ 2023, 10, 30 ] ], "date-time": "2023-10-30T17:55:07Z", "timestamp": 1698688507990 }, "is-referenced-by-count": 8, "issued": { "date-parts": [ [ 2020 ] ] }, "language": "en", "member": "78", "original-title": [], "prefix": "10.2139", "published": { "date-parts": [ [ 2020 ] ] }, "published-other": { "date-parts": [ [ 2020 ] ] }, "publisher": "Elsevier BV", "reference-count": 0, "references-count": 0, "relation": {}, "resource": { "primary": { "URL": "https://www.ssrn.com/abstract=3575899" } }, "score": 1, "short-title": [], "source": "Crossref", "subject": [], "subtitle": [], "title": "Countries which Primarily Use Antimalarial Drugs As COVID-19 Treatment See Slower Dynamic of Daily Deaths", "type": "journal-article" }
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. IMA and WCH provide treatment protocols.
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