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0 0.5 1 1.5 2+ Mortality 34% Improvement Relative Risk Severe case 48% Hospitalization 17% c19hcq.org Isnardi et al. NCT04568421 HCQ PrEP Favors HCQ Favors control
Sociodemographic and clinical factors associated with poor COVID-19 outcomes in patients with rheumatic diseases: data from the SAR-COVID Registry
Isnardi et al., Clinical Rheumatology, doi:10.1007/s10067-022-06393-8, NCT04568421 (history)
6 Oct 2022    Source   PDF   Share   Tweet
Retrospective 1,915 rheumatic disease patients with COVID-19 in Argentina, showing lower mortality, severe oxygen requirement, and hospitalization with CQ/HCQ (antimalarial) use in unadjusted results, statistically significant only for severe oxygen requirement.
risk of death, 33.9% lower, RR 0.66, p = 0.23, treatment 11 of 361 (3.0%), control 72 of 1,554 (4.6%), NNT 63, odds ratio converted to relative risk.
risk of severe case, 48.0% lower, RR 0.52, p = 0.02, treatment 14 of 361 (3.9%), control 117 of 1,554 (7.5%), NNT 27, odds ratio converted to relative risk.
risk of hospitalization, 17.0% lower, RR 0.83, p = 0.09, treatment 83 of 512 (16.2%), control 429 of 1,554 (27.6%), NNT 8.8, odds ratio converted to relative risk.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Isnardi et al., 6 Oct 2022, retrospective, Argentina, peer-reviewed, mean age 51.4, 199 authors, study period 13 August, 2020 - 31 July, 2021, trial NCT04568421 (history).
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