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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality 55% Improvement Relative Risk ICU admission 29% Hospitalization 37% HCQ for COVID-19  Ip et al.  EARLY TREATMENT Is early treatment with HCQ beneficial for COVID-19? Retrospective 1,067 patients in the USA Lower hospitalization with HCQ (p=0.038) c19hcq.org Ip et al., BMC Infectious Diseases, Aug 2020 Favors HCQ Favors control

Hydroxychloroquine in the treatment of outpatients with mildly symptomatic COVID-19: A multi-center observational study

Ip et al., BMC Infectious Diseases, doi:10.1186/s12879-021-05773-w (date from preprint)
Aug 2020  
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HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now known with p < 0.00000000001 from 421 studies, recognized in 42 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments. c19hcq.org
Retrospective 1,274 outpatients, 47% reduction in hospitalization with HCQ with propensity matching, HCQ OR 0.53 [0.29-0.95]. Sensitivity analyses revealed similar associations.
Adverse events were not increased (2% QTc prolongation events, 0% arrhythmias).
risk of death, 54.5% lower, RR 0.45, p = 0.43, treatment 2 of 97 (2.1%), control 44 of 970 (4.5%), NNT 40.
risk of ICU admission, 28.6% lower, RR 0.71, p = 0.79, treatment 3 of 97 (3.1%), control 42 of 970 (4.3%), NNT 81.
risk of hospitalization, 37.3% lower, RR 0.63, p = 0.04, treatment 21 of 97 (21.6%), control 305 of 970 (31.4%), NNT 10, adjusted per study, odds ratio converted to relative risk.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Ip et al., 25 Aug 2020, retrospective, database analysis, USA, peer-reviewed, 25 authors, dosage not specified.
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