Analgesics
Antiandrogens
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Results
Abstract
All HCQ studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19hcq.org COVID-19 treatment researchHCQHCQ (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

Clinical characteristics and outcomes among hospitalized adults with severe COVID-19 admitted to a tertiary medical center and receiving antiviral, antimalarials, glucocorticoids, or immunomodulation with tocilizumab or cyclosporine: A retrospective observational study (COQUIMA cohort)

Guisado-Vasco et al., EClinicalMedicine, doi:10.1016/j.eclinm.2020.100591
Oct 2020  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Mortality 20% Improvement Relative Risk Outpatient use 88% HCQ for COVID-19  Guisado-Vasco et al.  LATE TREATMENT Is late treatment with HCQ beneficial for COVID-19? Retrospective 607 patients in Spain Lower mortality with HCQ (not stat. sig., p=0.36) c19hcq.org Guisado-Vasco et al., EClinicalMedicine, Oct 2020 FavorsHCQ Favorscontrol 0 0.5 1 1.5 2+
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now with p < 0.00000000001 from 411 studies, recognized in 46 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 75 treatments. c19hcq.org
Retrospective 607 patients reporting results for early outpatient HCQ use with mortality odds ratio OR 0.092 [0.022-0.381], p = 0.001 (65 patients), and for hospital use, mortality odds ratio OR 0.737 [0.38-1.41], p = 0.36 (558 patients). Median age 69.
risk of death, 20.3% lower, RR 0.80, p = 0.36, treatment 127 of 558 (22.8%), control 14 of 49 (28.6%), NNT 17, adjusted per study, odds ratio converted to relative risk.
outpatient use, 88.0% lower, RR 0.12, p = 0.001, treatment 2 of 65 (3.1%), control 139 of 542 (25.6%), NNT 4.4, adjusted per study, odds ratio converted to relative risk.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Guisado-Vasco et al., 15 Oct 2020, retrospective, Spain, peer-reviewed, median age 69.0, 25 authors.
This PaperHCQAll
Clinical characteristics and outcomes among hospitalized adults with severe COVID-19 admitted to a tertiary medical center and receiving antiviral, antimalarials, glucocorticoids, or immunomodulation with tocilizumab or cyclosporine: A retrospective observational study (COQUIMA cohort)
Pablo Guisado-Vasco, Sofia Valderas-Ortega, Maria Maravillas Carralón-González, Ana Roda-Santacruz, Lucia González-Cortijo, Gabriel Sotres-Fernández, Eva María Martí-Ballesteros, José Manuel Luque-Pinilla, Elena Almagro-Casado, Félix J La Coma-Lanuza, Ruth Barrena-Puertas, Esteban Javier Malo-Benages, María José Monforte-Gómez, Rocío Diez-Munar, Esther Merino-Lanza, Lorena Comeche-Casanova, Margarita Remirez-De-Esparza-Otero, María Correyero-Plaza, Manuel Recio-Rodríguez, Margarita Rodríguez-López, María Dolores Sánchez-Manzano, Cristina Andreu-Vázquez, Israel John Thuissard-Vasallo, José María Echave-Sustaeta María-Tomé, Daniel Carnevali-Ruiz
EClinicalMedicine, doi:10.1016/j.eclinm.2020.100591
Background: The COVID-19 outbreak challenges the Spanish health system since March 2020. Some available therapies (antimalarials, antivirals, biological agents) were grounded on clinical case observations or basic science data. The aim of this study is to describe the characteristics and impact of different therapies on clinical outcomes in a cohort of severe COVID-19 patients. Methods: In this retrospective, single-center, observational study, we collected sequential data on adult patients admitted to Hospital Universitario Quironsalud Madrid. Eligible patients should have a microbiological (positive test on RT-PCR assay from a nasal swab) or an epidemiological diagnosis of severe COVID-19. Demographic, baseline comorbidities, laboratory data, clinical outcomes, and treatments were compared between survivors and non-survivors. We carried out univariate and multivariate logistic regression models to assess potential risk factors for in-hospital mortality. Findings: From March 10th to April 15th, 2020, 607 patients were included. Median age was 69 years [interquartile range, {IQR} 22; 65% male). The most common comorbidities were hypertension (276 [46¢94%]),
JMES helped in the design of the study. ARS and SVO collected the data and coordinate the analysis. CAV and IJTV run the statistical analysis and designed the table and figures. JMLP, GSF, LGC, EAC, MDSM, MCG, RBP, EMMB, EJMB, MJMG, RDM, EMB, LCC, MREO, MCP, MRR, MRL, FLL collected data. PGV, DCR, CAV, IJTV, ARS, GSF, LGC drafted the paper. All authors critically revised the manuscript for important intellectual content and gave final approval for the version to be published. All authors agree to be accountable for all aspects of the work. They also in ensuring in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. Data sharing statement The dataset used for the present analyses, although partially anonymized, contains detailed and thus possibly identifiable patient data so that a publication of the database is not possible. However, upon reasonable and personal requests to the Authors, and as a further notification to the Ethics Committee and amendment of the study protocol, anonymous data would be shared with individual researchers or working groups. List of contributors Supplementary materials Supplementary material associated with this article can be found in the online version at doi:10.1016/j.eclinm.2020.100591.
References
Agresti, Coull, Approximate is better than 'Exact' for interval estimation of binominal proportions, Am Stat
Ai, Yang, Hou, Zhan, Chen et al., Correlation of chest CT and RT-PCR testing in coronavirus disease 2019 (COVID-19) in China: a report of 1014 cases, Radiology, doi:10.1148/radiol.2020200642
Akbar, Gilroy, Aging immunity may exacerbate COVID-19, Science
Ar Evalo-Rodríguez, Buitrago-García, Simancas-Racines, Zambrano-Archig, Del Campo R et al., False-negative results of initial RT-PCR assays for COVID-19: a systematic review, medRxiv, doi:10.1101/2020.04.16.20066787
Bassetti, Pelosi, Robba, Vena, Giacobbe, A brief note on randomized controlled trials and compassionate/ off-label use of drugs in the early phases of the COVID-19 pandemic, Drugs Context, doi:10.7573/dic.2020-5-2
Borba, Val, Sampaio, Alexandre, Melo et al., Effect high or low dose of chloroquine diphosphate as adjunctive therapy for patients hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: a randomized clinical trial, JAMA Netw Open, doi:10.1001/jamanetworkopen.2020.8857
Canziani, Trovati, Brunetta, Testa, De Santis et al., Interleukin-6 receptor blocking with intravenous tocilizumab in COVID-19 severe acute respiratory distress syndrome: a retrospective case-control survival analysis of 128 patients, J Autoimmun, doi:10.1016/j.jaut.2020.102511
Cao, Wang, Wen, Liu, Wang et al., A trial of lopinavir/ritonavir in adults hospitalized with severe COVID-19, N Engl J Med
Carbajo-Lozoya, M€ Uller, Kallies, Thiel, Drosten et al., Replication of human coronaviruses SARS-Cov, HCoV-NL63 and HCoV-229E is inhibited by the drug FK506, Virus Res
Cavagna, Seminari, Zanframundo, Gregorini, Di Matteo et al., Calcineurin inhibitor-based immunosuppression and COVID-19: results from a multidisciplinary cohort of patients in northern Italy, Microorganism, doi:10.3390/microorganisms8070977
Chen, Wu, Guo, Cao, Huang et al., Clinical and immunologic features in severe and moderate Coronavirus Disease 2019, J Clin Invest, doi:10.1172/JCI137244
Cour, Ovize, Argaud, Cyclosporine A: a valid candidate to treat COVID-19 patients with acute respiratory failure?, Critical Care
Cubillo, De La Higuera, Lucena, Franci, Hurtado et al., Should cyclosporine be useful in renal transplant recipients affected by SARS-CoV-2?, Am J Transplant, doi:10.1111/ajt.16141
Dawar, Xiong, Khattak, Li, Lin et al., Potential role of cyclophilin A in regulating cytokine secretion, J Leukoc Biol
De Wilde, Pham, Posthuma, Snijder, Cyclophilins and cyclophilin inhibitors in Nidovirus replication, Virology
Dhocherty, Harrison, Green, Hardwick, Pius et al., Features of 20,133 UK patients in hospital with COVID-19 using the ISARIC WHO clinical characterization protocol: prospective observational cohort study, BMJ, doi:10.1136/bmj.m1985
Fadel, Morrison, Vahia, Smith, Chaudhry et al., Early short course corticosteroids in hospitalized patients with COVID-19, Clin Infect Dis, doi:10.1093/cid/ciaa601
Grasselli, Zangrillo, Zanella, Antonelli, Cabrini et al., Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs on the Lombardy region Italy, JAMA
Hirano, Murakami, COVID-19:a new virus, but familiar receptor and cytokine release syndrome, Immunity, doi:10.1016/j.immuni.2020.04.003
Jin, Yang, Wu, Chen, Zhang, Virology, epidemiology, pathogenesis, and control of COVID-19, Viruses, doi:10.3390/v12040372
Li, Moore, Vasilieva, Sui, Wong et al., Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus, Nature
Liddicoat, Lavelle, Modulation of innate immunity by cyclosporine A, Biochem Pharmacol, doi:10.1016/j.bcp.2019.02.33
Luo, Liu, Qiu, Liu, Liu et al., Tocilizumab treatment in COVID-19: a singlecenter experience, J Med Virol
Ma-Laurer, Zheng, Sevi C M, Von Brunn, Fischer, Von Brunn, Influences of cyclosporin A and non-immunosupressive derivatives on cellular cyclophilins and viral nucleocapsid protein during human coronavirus 229E replication, Antiviral Res, doi:10.1016/j.antiviral.2019.104620
Mehta, Mcauley, Brown, Sanchez, Manson JJ on behalf of the HLH across specialty collaboration UK. COVID-19: consider cytokine storm syndrome and immunosuppression, Lancet, doi:10.1016/S0140-6736(20)30628-0
Molyvdas, Matalon, Cyclosporine: an old weapon in the fight against Coronaviruses, Eur Respir J, doi:10.1183/13993003.02484-2020[Epubaheadofprint]
Onder, Rezza, Brusaferro, Case-fatality rate and characteristics of patients dying in relation to COVID-19 in Italy, JAMA, doi:10.1001/jama.2020.4683
Petrilli, Jones, Yang, Rajagopalan, Donnel et al., Factors associated with hospital admission and critical illness among 5,279 people with coronavirus disease 2019 in New York city: prospective cohort study, BMJ, doi:10.1136/bmj.m1966
Pfefferle, Sch€ Opf, K€ Ogl, Friedel, M€ Uller et al., The SARS-coronavirus-host Interactome: identification of cyclophilins as target for pancoronavirus inhibitors, PLoS Pathog
Pierce, Lesniewski, Lawson, Beske, Seals, Nuclear factor-{kappa}B activation contributes to vascular endothelial dysfunction via oxidative stress in overweight/obese middle-aged and older humans, Circulation
Pizzorno, Padey, Dubois, Julien, Traversier et al., Invitro evaluation of antiviral activity of single and combined repurposable drugs against SARS-CoV-2, Antiviral Res, doi:10.1016/j.antiviral.2020.104878
Porter, Frey, Wood, Weng, Grupp, Grading of cytokine release syndrome associated with the CAR T cell therapy tisagenlecleucel, J Hematol Oncol
Ranganathan, Pramesh, Aggarwal, Common pitfall in statistical analysis: logistic regression, Perspect Clin Res
Rice, Wheeler, Bernard, Hayden, Schoenfeld et al., Comparison of the Spo2/Fio2 ratio and the Pao2/Fio2 ratio in patients with acute lung injury or ARDS. For the National Institutes of Health, National Heart, Lung, and Blood Institute ARDS Network, Chest
Richarson, Hirsch, Narasimhan, Crawford, Mcginn et al., Presenting characteristics, and outcomes among 5700 patients hospitalized with COVID-19 in New York City Area, JAMA, doi:10.1001/jama.2020.6775
Romanelli, Mascolo, Immunosuppression drug-related and clinical manifestation of coronavirus disease 2019: a therapeutical hypothesis, Am J Transplant, doi:10.1111/ajt.15905
Roschewski, Lonakis, Sharman, Roswarski, Goy et al., Inhibition of Bruton tyrosine kinase in patients with severe COVID-19, Science Immunol, doi:10.1126/sciimmunol.abd0110
Sarma, Kaur, Kumar, Mahendru, Avti et al., Virological and clinical cure in COVID-19 patients treated with hydroxychloroquine: a systematic review and meta-analysis, J Med Virol, doi:10.1002/jmv.25898
Sauerhering, Kupke, Meier, Dietzel, Hoppe et al., Cyclophilin inhibitors restrict Middle East Respiratory Syndrome Coronavirus via interferon λ; in vitro and in mice, Eur Respir J, doi:10.1183/13993003.01826-2019
Scheffert, Raza, Immunosuppression in lung transplantation, J Thorac Dis
Shimabukuro-Vornhagen G€ Odel, Subklewe, Stemmler, Schl€ Oßer, Schlaak, Cytokine release syndrome, J Immunother Cancer, doi:10.1186/s40425-018-0343-9
Siddiqi, Mehra, COVID-19 illness in native and immunosuppressed states: a clinical-therapeutic staging proposal, J Heart Lung Transplant, doi:10.1016/j.healun.2020.03.012
Sun, Guo, Zhang, Ha, Yokoyama, Cyclophilin A (CypA) interacts with NF-B subunit, p65/RelA, and contributes to NF-B activation signaling, PLoS ONE, doi:10.1371/journal.pone.0096211
Tabit, Shenouda, Holbrook, Fetterman, Kiani et al., Protein kinase C-b contributes to impaired endothelial insulin signaling in humans with diabetes mellitus, Circulation
Tanaka, Sato, Sasaki, Suppression of Coronavirus replication by cyclophilin inhibitors, Viruses
The, Group, Dexamethasone in hospitalized patients with Covid-19 -preliminary report, NEJM, doi:10.1056/NEJMoa2021436
Wong, Lam, Fong, Leung, Chin et al., Frequency and correlation of chest radiographic findings in COVID-19 positive patients, Radiology, doi:10.1148/radiol.2020201160
Wu, Zhao, Yu, Chen, A new coronavirus associated with human respiratory disease in China, Nature
Xu, Han, Li, Sun, Wang et al., Effective treatment of severe COVID-19 patients with tocilizumab, Proc Natl Acad Sci
Xu, Shi, Wang, Zhang, Huang et al., Pathological findings of COVID-19 associated with acute respiratory distress syndrome, Lancet Respir Med
Zhou, Yu, Du, Fan, Liu et al., Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study, Lancet
{ 'indexed': {'date-parts': [[2024, 5, 11]], 'date-time': '2024-05-11T15:13:56Z', 'timestamp': 1715440436908}, 'reference-count': 51, 'publisher': 'Elsevier BV', 'license': [ { 'start': { 'date-parts': [[2020, 11, 1]], 'date-time': '2020-11-01T00:00:00Z', 'timestamp': 1604188800000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://www.elsevier.com/tdm/userlicense/1.0/'}, { 'start': { 'date-parts': [[2020, 9, 28]], 'date-time': '2020-09-28T00:00:00Z', 'timestamp': 1601251200000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'http://creativecommons.org/licenses/by-nc-nd/4.0/'}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'published-print': {'date-parts': [[2020, 11]]}, 'DOI': '10.1016/j.eclinm.2020.100591', 'type': 'journal-article', 'created': { 'date-parts': [[2020, 10, 15]], 'date-time': '2020-10-15T09:00:21Z', 'timestamp': 1602752421000}, 'page': '100591', 'source': 'Crossref', 'is-referenced-by-count': 70, 'title': 'Clinical characteristics and outcomes among hospitalized adults with severe COVID-19 admitted to ' 'a tertiary medical center and receiving antiviral, antimalarials, glucocorticoids, or ' 'immunomodulation with tocilizumab or cyclosporine: A retrospective observational study (COQUIMA ' 'cohort)', 'prefix': '10.1016', 'volume': '28', 'author': [ { 'ORCID': 'http://orcid.org/0000-0003-3019-4398', 'authenticated-orcid': False, 'given': 'Pablo', 'family': 'Guisado-Vasco', 'sequence': 'first', 'affiliation': []}, {'given': 'Sofia', 'family': 'Valderas-Ortega', 'sequence': 'additional', 'affiliation': []}, { 'given': 'Maria Maravillas', 'family': 'Carralón-González', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ana', 'family': 'Roda-Santacruz', 'sequence': 'additional', 'affiliation': []}, {'given': 'Lucia', 'family': 'González-Cortijo', 'sequence': 'additional', 'affiliation': []}, {'given': 'Gabriel', 'family': 'Sotres-Fernández', 'sequence': 'additional', 'affiliation': []}, { 'given': 'Eva María', 'family': 'Martí-Ballesteros', 'sequence': 'additional', 'affiliation': []}, { 'given': 'José Manuel', 'family': 'Luque-Pinilla', 'sequence': 'additional', 'affiliation': []}, {'given': 'Elena', 'family': 'Almagro-Casado', 'sequence': 'additional', 'affiliation': []}, {'given': 'Félix J.', 'family': 'La Coma-Lanuza', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ruth', 'family': 'Barrena-Puertas', 'sequence': 'additional', 'affiliation': []}, { 'given': 'Esteban Javier', 'family': 'Malo-Benages', 'sequence': 'additional', 'affiliation': []}, { 'given': 'María José', 'family': 'Monforte-Gómez', 'sequence': 'additional', 'affiliation': []}, {'given': 'Rocío', 'family': 'Diez-Munar', 'sequence': 'additional', 'affiliation': []}, {'given': 'Esther', 'family': 'Merino-Lanza', 'sequence': 'additional', 'affiliation': []}, {'given': 'Lorena', 'family': 'Comeche-Casanova', 'sequence': 'additional', 'affiliation': []}, { 'given': 'Margarita', 'family': 'Remirez-de-Esparza-Otero', 'sequence': 'additional', 'affiliation': []}, {'given': 'María', 'family': 'Correyero-Plaza', 'sequence': 'additional', 'affiliation': []}, {'given': 'Manuel', 'family': 'Recio-Rodríguez', 'sequence': 'additional', 'affiliation': []}, { 'given': 'Margarita', 'family': 'Rodríguez-López', 'sequence': 'additional', 'affiliation': []}, { 'given': 'María Dolores', 'family': 'Sánchez-Manzano', 'sequence': 'additional', 'affiliation': []}, {'given': 'Cristina', 'family': 'Andreu-Vázquez', 'sequence': 'additional', 'affiliation': []}, { 'given': 'Israel John', 'family': 'Thuissard-Vasallo', 'sequence': 'additional', 'affiliation': []}, { 'given': 'José María Echave-Sustaeta', 'family': 'María-Tomé', 'sequence': 'additional', 'affiliation': []}, {'given': 'Daniel', 'family': 'Carnevali-Ruiz', 'sequence': 'additional', 'affiliation': []}], 'member': '78', 'reference': [ { 'issue': '7798', 'key': '10.1016/j.eclinm.2020.100591_bib0001', 'doi-asserted-by': 'crossref', 'first-page': '265', 'DOI': '10.1038/s41586-020-2008-3', 'article-title': 'A new coronavirus associated with human respiratory disease in China', 'volume': '579', 'author': 'Wu', 'year': '2020', 'journal-title': 'Nature'}, { 'key': '10.1016/j.eclinm.2020.100591_bib0002', 'doi-asserted-by': 'crossref', 'first-page': '372', 'DOI': '10.3390/v12040372', 'article-title': 'Virology, epidemiology, pathogenesis, and control of COVID-19', 'volume': '12', 'author': 'Jin', 'year': '2020', 'journal-title': 'Viruses'}, { 'issue': '4', 'key': '10.1016/j.eclinm.2020.100591_bib0003', 'doi-asserted-by': 'crossref', 'first-page': '420', 'DOI': '10.1016/S2213-2600(20)30076-X', 'article-title': 'Pathological findings of COVID-19 associated with acute respiratory ' 'distress syndrome', 'volume': '8', 'author': 'Xu', 'year': '2020', 'journal-title': 'Lancet Respir Med'}, { 'issue': '10229', 'key': '10.1016/j.eclinm.2020.100591_bib0004', 'doi-asserted-by': 'crossref', 'first-page': '1054', 'DOI': '10.1016/S0140-6736(20)30566-3', 'article-title': 'Clinical course and risk factors for mortality of adult inpatients with ' 'COVID-19 in Wuhan, China: a retrospective cohort study', 'volume': '395', 'author': 'Zhou', 'year': '2020', 'journal-title': 'Lancet'}, { 'key': '10.1016/j.eclinm.2020.100591_bib0005', 'doi-asserted-by': 'crossref', 'DOI': '10.1001/jama.2020.4683', 'article-title': 'Case-fatality rate and characteristics of patients dying in relation to ' 'COVID-19 in Italy', 'author': 'Onder', 'year': '2020', 'journal-title': 'JAMA'}, { 'issue': '16', 'key': '10.1016/j.eclinm.2020.100591_bib0006', 'doi-asserted-by': 'crossref', 'first-page': '1574', 'DOI': '10.1001/jama.2020.5394', 'article-title': 'Baseline characteristics and outcomes of 1591 patients infected with ' 'SARS-CoV-2 admitted to ICUs on the Lombardy region Italy', 'volume': '323', 'author': 'Grasselli', 'year': '2020', 'journal-title': 'JAMA'}, { 'issue': '7', 'key': '10.1016/j.eclinm.2020.100591_bib0007', 'doi-asserted-by': 'crossref', 'first-page': '776', 'DOI': '10.1002/jmv.25898', 'article-title': 'Virological and clinical cure in COVID-19 patients treated with ' 'hydroxychloroquine: a systematic review and meta-analysis', 'volume': '92', 'author': 'Sarma', 'year': '2020', 'journal-title': 'J Med Virol'}, { 'issue': '4', 'key': '10.1016/j.eclinm.2020.100591_bib0008', 'doi-asserted-by': 'crossref', 'DOI': '10.1001/jamanetworkopen.2020.8857', 'article-title': 'Effect high or low dose of chloroquine diphosphate as adjunctive ' 'therapy for patients hospitalized with severe acute respiratory ' 'syndrome coronavirus 2 (SARS-CoV-2) infection: a randomized clinical ' 'trial', 'volume': '3', 'author': 'Borba', 'year': '2020', 'journal-title': 'JAMA Netw Open'}, { 'issue': '19', 'key': '10.1016/j.eclinm.2020.100591_bib0009', 'doi-asserted-by': 'crossref', 'first-page': '1787', 'DOI': '10.1056/NEJMoa2001282', 'article-title': 'A trial of lopinavir/ritonavir in adults hospitalized with severe ' 'COVID-19', 'volume': '382', 'author': 'Cao', 'year': '2020', 'journal-title': 'N Engl J Med'}, { 'issue': '7', 'key': '10.1016/j.eclinm.2020.100591_bib0010', 'doi-asserted-by': 'crossref', 'first-page': '814', 'DOI': '10.1002/jmv.25801', 'article-title': 'Tocilizumab treatment in COVID-19: a single-center experience', 'volume': '92', 'author': 'Luo', 'year': '2020', 'journal-title': 'J Med Virol'}, { 'issue': '209', 'key': '10.1016/j.eclinm.2020.100591_bib0011', 'doi-asserted-by': 'crossref', 'first-page': '10970', 'DOI': '10.1073/pnas.2005615117', 'article-title': 'Effective treatment of severe COVID-19 patients with tocilizumab', 'volume': '117', 'author': 'Xu', 'year': '2020', 'journal-title': 'Proc Natl Acad Sci USA'}, { 'key': '10.1016/j.eclinm.2020.100591_bib0012', 'doi-asserted-by': 'crossref', 'DOI': '10.7573/dic.2020-5-2', 'article-title': 'A brief note on randomized controlled trials and compassionate/ ' 'off-label use of drugs in the early phases of the COVID-19 pandemic', 'volume': '9', 'author': 'Bassetti', 'year': '2020', 'journal-title': 'Drugs Context'}, { 'issue': '5', 'key': '10.1016/j.eclinm.2020.100591_bib0013', 'doi-asserted-by': 'crossref', 'first-page': '405', 'DOI': '10.1016/j.healun.2020.03.012', 'article-title': 'COVID-19 illness in native and immunosuppressed states: a ' 'clinical-therapeutic staging proposal', 'volume': '39', 'author': 'Siddiqi', 'year': '2020', 'journal-title': 'J Heart Lung Transplant'}, { 'issue': '1', 'key': '10.1016/j.eclinm.2020.100591_bib0014', 'doi-asserted-by': 'crossref', 'first-page': '56', 'DOI': '10.1186/s40425-018-0343-9', 'article-title': 'Cytokine release syndrome', 'volume': '6', 'author': 'Shimabukuro-Vornhagen', 'year': '2018', 'journal-title': 'J Immunother Cancer'}, { 'key': '10.1016/j.eclinm.2020.100591_bib0015', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/S0140-6736(20)30628-0', 'article-title': 'Manson JJ on behalf of the HLH across specialty collaboration UK. ' 'COVID-19: consider cytokine storm syndrome and immunosuppression', 'author': 'Mehta', 'year': '2020', 'journal-title': 'Lancet'}, { 'issue': '8', 'key': '10.1016/j.eclinm.2020.100591_bib0016', 'doi-asserted-by': 'crossref', 'first-page': 'e96211', 'DOI': '10.1371/journal.pone.0096211', 'article-title': 'Cyclophilin A (CypA) interacts with NF-B subunit, p65/RelA, and ' 'contributes to NF-B activation signaling', 'volume': '9', 'author': 'Sun', 'year': '2014', 'journal-title': 'PLoS ONE'}, { 'issue': '6965', 'key': '10.1016/j.eclinm.2020.100591_bib0017', 'doi-asserted-by': 'crossref', 'first-page': '450', 'DOI': '10.1038/nature02145', 'article-title': 'Angiotensin-converting enzyme 2 is a functional receptor for the SARS ' 'coronavirus', 'volume': '426', 'author': 'Li', 'year': '2003', 'journal-title': 'Nature'}, { 'issue': '5', 'key': '10.1016/j.eclinm.2020.100591_bib0018', 'doi-asserted-by': 'crossref', 'first-page': '1250', 'DOI': '10.3390/v5051250', 'article-title': 'Suppression of Coronavirus replication by cyclophilin inhibitors', 'volume': '5', 'author': 'Tanaka', 'year': '2013', 'journal-title': 'Viruses'}, { 'issue': '5', 'key': '10.1016/j.eclinm.2020.100591_bib0019', 'doi-asserted-by': 'crossref', 'first-page': '731', 'DOI': '10.1016/j.immuni.2020.04.003', 'article-title': 'Murakami M.COVID-19:a new virus, but familiar receptor and cytokine ' 'release syndrome', 'volume': '52', 'author': 'Hirano', 'year': '2020', 'journal-title': 'Immunity'}, { 'issue': '4', 'key': '10.1016/j.eclinm.2020.100591_bib0020', 'doi-asserted-by': 'crossref', 'first-page': '989', 'DOI': '10.1189/jlb.3RU0317-090RR', 'article-title': 'Potential role of cyclophilin A in regulating cytokine secretion', 'volume': '102', 'author': 'Dawar', 'year': '2017', 'journal-title': 'J Leukoc Biol'}, { 'issue': '7', 'key': '10.1016/j.eclinm.2020.100591_bib0021', 'doi-asserted-by': 'crossref', 'first-page': '1947', 'DOI': '10.1111/ajt.15905', 'article-title': 'Immunosuppression drug-related and clinical manifestation of ' 'coronavirus disease 2019: a therapeutical hypothesis', 'volume': '20', 'author': 'Romanelli', 'year': '2020', 'journal-title': 'Am J Transplant'}, { 'issue': '2', 'key': '10.1016/j.eclinm.2020.100591_bib0022', 'doi-asserted-by': 'crossref', 'first-page': 'E72', 'DOI': '10.1148/radiol.2020201160', 'article-title': 'Frequency and correlation of chest radiographic findings in COVID-19 ' 'positive patients', 'volume': '296', 'author': 'Wong', 'year': '2020', 'journal-title': 'Radiology'}, { 'issue': '2', 'key': '10.1016/j.eclinm.2020.100591_bib0023', 'doi-asserted-by': 'crossref', 'first-page': 'E32', 'DOI': '10.1148/radiol.2020200642', 'article-title': 'Correlation of chest CT and RT-PCR testing in coronavirus disease 2019 ' '(COVID-19) in China: a report of 1014 cases', 'volume': '296', 'author': 'Ai', 'year': '2020', 'journal-title': 'Radiology'}, { 'issue': '2', 'key': '10.1016/j.eclinm.2020.100591_bib0024', 'first-page': '400', 'article-title': 'Comparison of the Spo2/Fio2 ratio and the Pao2/Fio2 ratio in patients ' 'with acute lung injury or ARDS. For the National Institutes of Health, ' 'National Heart, Lung, and Blood Institute ARDS Network', 'volume': '132', 'author': 'Rice', 'year': '2007', 'journal-title': 'Chest'}, { 'key': '10.1016/j.eclinm.2020.100591_bib0025', 'doi-asserted-by': 'crossref', 'unstructured': 'Arévalo-Rodríguez I, Buitrago-García D, Simancas-Racines D, ' 'Zambrano-Archig P, del Campo R, Ciapponi A. et\xa0al. False-negative ' 'results of initial RT-PCR assays for COVID-19: a systematic review. ' 'medRxiv 2020.04.16.20066787. doi: ' 'https://doi.org/10.1101/2020.04.16.20066787.', 'DOI': '10.1101/2020.04.16.20066787'}, { 'issue': '8', 'key': '10.1016/j.eclinm.2020.100591_bib0026', 'first-page': '1039', 'article-title': 'Immunosuppression in lung transplantation', 'volume': '6', 'author': 'Scheffert', 'year': '2014', 'journal-title': 'J Thorac Dis'}, { 'key': '10.1016/j.eclinm.2020.100591_bib0027', 'first-page': '119', 'article-title': 'Approximate is better than ‘Exact’ for interval estimation of binominal ' 'proportions', 'volume': '52', 'author': 'Agresti', 'year': '1998', 'journal-title': 'Am Stat'}, { 'key': '10.1016/j.eclinm.2020.100591_bib0028', 'first-page': '369', 'article-title': 'Features of 20,133 UK patients in hospital with COVID-19 using the ' 'ISARIC WHO clinical characterization protocol: prospective ' 'observational cohort study', 'volume': '2020', 'author': 'Dhocherty', 'year': '1985', 'journal-title': 'BMJ'}, { 'issue': '20', 'key': '10.1016/j.eclinm.2020.100591_bib0029', 'doi-asserted-by': 'crossref', 'first-page': '2052', 'DOI': '10.1001/jama.2020.6775', 'article-title': 'Presenting characteristics, and outcomes among 5700 patients ' 'hospitalized with COVID-19 in New York City Area', 'volume': '323', 'author': 'Richarson', 'year': '2020', 'journal-title': 'JAMA'}, { 'issue': '3', 'key': '10.1016/j.eclinm.2020.100591_bib0030', 'first-page': '148', 'article-title': 'Common pitfall in statistical analysis: logistic regression', 'volume': '8', 'author': 'Ranganathan', 'year': '2017', 'journal-title': 'Perspect Clin Res'}, { 'issue': '7', 'key': '10.1016/j.eclinm.2020.100591_bib0031', 'doi-asserted-by': 'crossref', 'first-page': 'E977', 'DOI': '10.3390/microorganisms8070977', 'article-title': 'Calcineurin inhibitor-based immunosuppression and COVID-19: results ' 'from a multidisciplinary cohort of patients in northern Italy', 'volume': '8', 'author': 'Cavagna', 'year': '2020', 'journal-title': 'Microorganism'}, { 'key': '10.1016/j.eclinm.2020.100591_bib0032', 'doi-asserted-by': 'crossref', 'DOI': '10.1111/ajt.16141', 'article-title': 'Should cyclosporine be useful in renal transplant recipients affected ' 'by SARS-CoV-2?', 'author': 'Rodríguez Cubillo', 'year': '2020', 'journal-title': 'Am J Transplant'}, { 'key': '10.1016/j.eclinm.2020.100591_bib0033', 'doi-asserted-by': 'crossref', 'first-page': '276', 'DOI': '10.1186/s13054-020-03014-1', 'article-title': 'Cyclosporine A: a valid candidate to treat COVID-19 patients with acute ' 'respiratory failure?', 'volume': '24', 'author': 'Cour', 'year': '2020', 'journal-title': 'Critical Care'}, { 'key': '10.1016/j.eclinm.2020.100591_bib0034', 'article-title': 'Cyclosporine: an old weapon in the fight against Coronaviruses', 'volume': 'Jul 30 : 2002484', 'author': 'Molyvdas', 'year': '2020', 'journal-title': 'Eur Respir J'}, { 'key': '10.1016/j.eclinm.2020.100591_bib0035', 'article-title': 'Cyclophilin inhibitors restrict Middle East Respiratory Syndrome ' 'Coronavirus via interferon λ; in vitro and in mice', 'volume': 'Jul 2: 1901826.', 'author': 'Sauerhering', 'year': '2020', 'journal-title': 'Eur Respir J'}, { 'key': '10.1016/j.eclinm.2020.100591_bib0036', 'article-title': 'Influences of cyclosporin A and non-immunosupressive derivatives on ' 'cellular cyclophilins and viral nucleocapsid protein during human ' 'coronavirus 229E replication', 'volume': '173', 'author': 'Ma-Laurer', 'year': '2020', 'journal-title': 'Antiviral Res'}, { 'key': '10.1016/j.eclinm.2020.100591_bib0037', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.antiviral.2020.104878', 'article-title': 'Invitro evaluation of antiviral activity of single and combined ' 'repurposable drugs against SARS-CoV-2', 'volume': '181', 'author': 'Pizzorno', 'year': '2020', 'journal-title': 'Antiviral Res'}, { 'issue': '10', 'key': '10.1016/j.eclinm.2020.100591_bib0038', 'doi-asserted-by': 'crossref', 'DOI': '10.1371/journal.ppat.1002331', 'article-title': 'The SARS-coronavirus-host Interactome: identification of cyclophilins ' 'as target for pancoronavirus inhibitors', 'volume': '7', 'author': 'Pfefferle', 'year': '2011', 'journal-title': 'PLoS Pathog'}, { 'issue': '1', 'key': '10.1016/j.eclinm.2020.100591_bib0039', 'doi-asserted-by': 'crossref', 'first-page': '112', 'DOI': '10.1016/j.virusres.2012.02.002', 'article-title': 'Replication of human coronaviruses SARS-Cov, HCoV-NL63 and HCoV-229E is ' 'inhibited by the drug FK506', 'volume': '165', 'author': 'Carbajo-Lozoya', 'year': '2012', 'journal-title': 'Virus Res'}, { 'key': '10.1016/j.eclinm.2020.100591_bib0040', 'doi-asserted-by': 'crossref', 'first-page': '42', 'DOI': '10.1016/j.virol.2018.06.011', 'article-title': 'Cyclophilins and cyclophilin inhibitors in Nidovirus replication', 'volume': '522', 'author': 'de Wilde', 'year': '2018', 'journal-title': 'Virology'}, { 'key': '10.1016/j.eclinm.2020.100591_bib0041', 'doi-asserted-by': 'crossref', 'first-page': '472', 'DOI': '10.1016/j.bcp.2019.03.022', 'article-title': 'Modulation of innate immunity by cyclosporine A', 'volume': '163', 'author': 'Liddicoat', 'year': '2019', 'journal-title': 'Biochem Pharmacol'}, { 'key': '10.1016/j.eclinm.2020.100591_bib0042', 'doi-asserted-by': 'crossref', 'first-page': '1284', 'DOI': '10.1161/CIRCULATIONAHA.108.804294', 'article-title': 'Nuclear factor-{kappa}B activation contributes to vascular endothelial ' 'dysfunction via oxidative stress in overweight/obese middle-aged and ' 'older humans', 'volume': '119', 'author': 'Pierce', 'year': '2009', 'journal-title': 'Circulation'}, { 'issue': '1', 'key': '10.1016/j.eclinm.2020.100591_bib0043', 'doi-asserted-by': 'crossref', 'first-page': '86', 'DOI': '10.1161/CIRCULATIONAHA.112.127514', 'article-title': 'Protein kinase C-b contributes to impaired endothelial insulin ' 'signaling in humans with diabetes mellitus', 'volume': '127', 'author': 'Tabit', 'year': '2013', 'journal-title': 'Circulation'}, { 'issue': '6501', 'key': '10.1016/j.eclinm.2020.100591_bib0044', 'doi-asserted-by': 'crossref', 'first-page': '256', 'DOI': '10.1126/science.abb0762', 'article-title': 'Aging immunity may exacerbate COVID-19', 'volume': '369', 'author': 'Akbar', 'year': '2020', 'journal-title': 'Science'}, { 'issue': '48', 'key': '10.1016/j.eclinm.2020.100591_bib0045', 'doi-asserted-by': 'crossref', 'first-page': 'eabd110', 'DOI': '10.1126/sciimmunol.abd0110', 'article-title': 'Inhibition of Bruton tyrosine kinase in patients with severe COVID-19', 'volume': '5', 'author': 'Roschewski', 'year': '2020', 'journal-title': 'Science Immunol'}, { 'issue': '5', 'key': '10.1016/j.eclinm.2020.100591_bib0046', 'doi-asserted-by': 'crossref', 'first-page': '2620', 'DOI': '10.1172/JCI137244', 'article-title': 'Clinical and immunologic features in severe and moderate Coronavirus ' 'Disease 2019', 'volume': '130', 'author': 'Chen', 'year': '2020', 'journal-title': 'J Clin Invest'}, { 'key': '10.1016/j.eclinm.2020.100591_bib0047', 'first-page': '369', 'article-title': 'Factors associated with hospital admission and critical illness among ' '5,279 people with coronavirus disease 2019 in New York city: ' 'prospective cohort study', 'author': 'Petrilli', 'year': '2020', 'journal-title': 'BMJ'}, { 'issue': '1', 'key': '10.1016/j.eclinm.2020.100591_bib0048', 'doi-asserted-by': 'crossref', 'first-page': '35', 'DOI': '10.1186/s13045-018-0571-y', 'article-title': 'Grading of cytokine release syndrome associated with the CAR T cell ' 'therapy tisagenlecleucel', 'volume': '11', 'author': 'Porter', 'year': '2018', 'journal-title': 'J Hematol Oncol'}, { 'key': '10.1016/j.eclinm.2020.100591_bib0049', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.jaut.2020.102511', 'article-title': 'Interleukin-6 receptor blocking with intravenous tocilizumab in ' 'COVID-19 severe acute respiratory distress syndrome: a retrospective ' 'case-control survival analysis of 128 patients', 'author': 'Canziani', 'year': '2020', 'journal-title': 'J Autoimmun'}, { 'key': '10.1016/j.eclinm.2020.100591_bib0050', 'doi-asserted-by': 'crossref', 'DOI': '10.1093/cid/ciaa601', 'article-title': 'Early short course corticosteroids in hospitalized patients with ' 'COVID-19', 'author': 'Fadel', 'year': '2020', 'journal-title': 'Clin Infect Dis'}, { 'key': '10.1016/j.eclinm.2020.100591_bib0051', 'article-title': 'Dexamethasone in hospitalized patients with Covid-19 - preliminary ' 'report', 'year': '2020', 'journal-title': 'NEJM'}], 'container-title': 'EClinicalMedicine', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://api.elsevier.com/content/article/PII:S2589537020303357?httpAccept=text/xml', 'content-type': 'text/xml', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://api.elsevier.com/content/article/PII:S2589537020303357?httpAccept=text/plain', 'content-type': 'text/plain', 'content-version': 'vor', 'intended-application': 'text-mining'}], 'deposited': { 'date-parts': [[2021, 6, 13]], 'date-time': '2021-06-13T07:56:35Z', 'timestamp': 1623570995000}, 'score': 1, 'resource': {'primary': {'URL': 'https://linkinghub.elsevier.com/retrieve/pii/S2589537020303357'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2020, 11]]}, 'references-count': 51, 'alternative-id': ['S2589537020303357'], 'URL': 'http://dx.doi.org/10.1016/j.eclinm.2020.100591', 'relation': {}, 'ISSN': ['2589-5370'], 'subject': [], 'container-title-short': 'EClinicalMedicine', 'published': {'date-parts': [[2020, 11]]}, 'article-number': '100591'}
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit