Antirheumatic Drug Intake Influence on Occurrence of COVID-19 Infection in Ambulatory Patients with Immune-Mediated Inflammatory Diseases: A Cohort Study
Debellemanière Guillaume, Bouvet Magalie, Elahi Sina, Salah-Mabed Imène, Vayr Frédéric, Dubois Mathieu, Muselier Aurore, Gozlan Yoni, Elbaz Emma, Badatcheff Charlotte, Fabre Laura, Saad Alain, Nahaisi Steven, Zeboulon Pierre, Febbraro Jean-Luc, Courtin Romain, Grise-Dulac Alice, Mazharian Adrien, Ghazal Wassim, Remongin Pierre-Emmanuel, Panthier Christophe, Chirouze Catherine, Bertrand Kevin, Sené Thomas, Gatinel Damien
Rheumatology and Therapy, doi:10.1007/s40744-021-00373-1
Introduction: We aimed to study the prevalence of a history of COVID-19 infection among patients suffering from systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjo ¨gren's syndrome (SjS) or psoriatic arthritis (PsA), and the potential influence of long-term hydroxychloroquine (HCQ) intake. Methods: We performed an observational monocentric cohort study at the Adolphe de Rothschild Foundation Hospital ophthalmology division (Paris, France). Electronic medical records (EMR) data were searched for keywords associated with SLE, RA, SjS, or PsA. Patients were contacted by phone and were interviewed using a standardized questionnaire. The primary outcome was the occurrence of a positive COVID-19 test result during the study period. We determined the adjusted association between various antirheumatic drugs intake, COVID-19 risk factors, and occurrence of COVID-19 using a logistic regression model. This study is registered on ClinicalTrials.gov (Identifier: NCT04345159). Results: Patients were recruited between Apr 17, 2020, and Apr 30, 2020 and were recontacted between Oct 6, 2020, and Nov 2, 2020. A total of 569 patients were included, of whom 459 patients were eligible for data analysis. One hundred and eighty-one patients were treated with long-term HCQ and 18 patients had tested positive for COVID-19. No antirheumatic drug intake, including HCQ intake, was significantly associated with an increased or decreased risk of developing COVID-19 infection. Conclusions: No antirheumatic drug intake was associated with an increased or decreased risk of developing COVID-19 infection in our cohort of patients suffering from immune-mediated inflammatory diseases.
References
Ader, Peiffer-Smadja, Poissy, Bouscambert-Duchamp, Belhadi et al., An openlabel randomized controlled trial of the effect of lopinavir/ritonavir, lopinavir/ritonavir plus IFN-b-1a and hydroxychloroquine in hospitalized patients with COVID-19, Clin Microbiol Infect,
doi:10.1016/j.cmi.2021.05.020
Amani, Khanijahani, Amani, Hydroxychloroquine plus standard of care compared with standard of care alone in COVID-19: a meta-analysis of randomized controlled trials, Sci Rep
Axfors, Schmitt, Janiaud, Van't Hooft, Abd-Elsalam et al., Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials, Nat Commun
Castelnuovo, Costanzo, Cassone, Cauda, Gaetano et al., Hydroxychloroquine and mortality in COVID-19 patients: a systematic review and a meta-analysis of observational studies and randomized controlled trials
Cavalcanti, Zampieri, Rosa, Azevedo, Veiga et al., Hydroxychloroquine with or without azithromycin in mild-to-moderate Covid-19, N Engl J Med
Cordtz, Lindhardsen, Soussi, Vela, Uhrenholt et al., Incidence and severeness of COVID-19 hospitalisation in patients with inflammatory rheumatic disease: a nationwide cohort study from Denmark, Rheumatology,
doi:10.1093/rheumatology/keaa897
Dalton, Gunzler, Jain, Perzynski, Dawson et al., Mechanisms of socioeconomic differences in COVID-19 screening and hospitalizations, PLoS ONE
Dube ´e, Roy, Vielle, Parot-Schinkel, Blanchet et al., Hydroxychloroquine in mild-to-moderate coronavirus disease 2019: a placebo-controlled double blind trial, Clin Microbiol Infect,
doi:10.1016/j.cmi.2021.03.005
Eze, Mezue, Nduka, Obianyo, Egbuche, Efficacy and safety of chloroquine and hydroxychloroquine for treatment of COVID-19 patients-a systematic review and meta-analysis of randomized controlled trials, Am J Cardiovasc Dis
Ferreira, Oliveira-E-Silva, Bettencourt, Chronic treatment with hydroxychloroquine and SARS-CoV-2 infection, J Med Virol
Galan, Santos, Asato, Arau ´jo, De Lima, Phase 2 randomized study on chloroquine, hydroxychloroquine or ivermectin in hospitalized patients with severe manifestations of SARS-CoV-2 infection
Gautret, Lagier, Parola, Hoang, Meddeb et al., Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial, Int J Antimicrob Agents
Geleris, Sun, Platt, Zucker, Baldwin et al., Observational study of hydroxychloroquine in hospitalized patients with Covid-19, N Engl J Med
Gerlovin, Posner, Ho, Rentsch, Tate et al., Pharmacoepidemiology, machine learning and COVID-19: an intent-to-treat analysis of hydroxychloroquine, with or without azithromycin, and COVID-19 outcomes amongst hospitalized US Veterans, Am J Epidemiol,
doi:10.1093/aje/kwab183
Gianfrancesco, Hyrich, Al-Adely, Carmona, Danila et al., Characteristics associated with hospitalisation for COVID-19 in people with rheumatic disease: data from the COVID-19 Global Rheumatology Alliance physician-reported registry, Ann Rheum Dis
Hernandez, Ingemi, Sherman, Pasupuleti, Barboza et al., Impact of prophylactic hydroxychloroquine on people at high risk of COVID-19: a systematic review and metaanalysis, J Clin Med Res,
doi:10.3390/jcm10122609
Hernandez, Phan, Pasupuleti, Barboza, Piscoya, Efficacy and safety of hydroxychloroquine for hospitalized COVID-19 patients: a systematic review and meta-analysis, J Clin Med Res,
doi:10.3390/jcm10112503
Johnston, Brown, Stewart, Karita, Kissinger et al., Hydroxychloroquine with or without azithromycin for treatment of early SARS-CoV-2 infection among high-risk outpatient adults: a randomized clinical trial
Konig, Kim, Scheetz, Graef, Liew et al., Baseline use of hydroxychloroquine in systemic lupus erythematosus does not preclude SARS-CoV-2 infection and severe COVID-19, Ann Rheum Dis
Lagier, Million, Gautret, Colson, Cortaredona et al., Outcomes of 3,737 COVID-19 patients treated with hydroxychloroquine/azithromycin and other regimens in Marseille, France: a retrospective analysis, Travel Med Infect Dis
Liu, Cao, Xu, Wang, Zhang et al., Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro, Cell Discov
Lo, Nguyen, Drew, Warner, Joshi et al., Chan AT, COPE Consortium. Race, ethnicity, community-level socioeconomic factors, and risk of COVID-19 in the United States and the United Kingdom
Mathian, Mahevas, Rohmer, Roumier, Cohen-Aubart et al., Clinical course of coronavirus disease 2019 (COVID-19) in a series of 17 patients with systemic lupus erythematosus under long-term treatment with hydroxychloroquine, Ann Rheum Dis
Pham, Torres, Satlin, Goyal, Gulick, Failure of chronic hydroxychloroquine in preventing severe complications of COVID-19 in patients with rheumatic diseases, Rheumatol Adv Pract
Re ´a-Neto, Bernardelli, Ca ˆmara, Bmd, Reese et al., An open-label randomized controlled trial evaluating the efficacy of chloroquine/hydroxychloroquine in severe COVID-19 patients, Sci Rep
Reis, Silva, Silva, Thabane, Singh et al., Effect of early treatment with hydroxychloroquine or lopinavir and ritonavir on risk of hospitalization among patients with COVID-19: the TOGETHER randomized clinical trial, JAMA Netw Open
Rentsch, Devito, Mackenna, Morton, Bhaskaran et al., Effect of pre-exposure use of hydroxychloroquine on COVID-19 mortality: a population-based cohort study in patients with rheumatoid arthritis or systemic lupus erythematosus using the OpenSAFELY platform, Lancet Rheumatol
Rosenberg, Dufort, Udo, Wilberschied, Kumar et al., Association of treatment with hydroxychloroquine or azithromycin with inhospital mortality in patients with COVID-19 in New York State, JAMA
Sammartino, Jafri, Cook, Kim, Cardasis, Predictors for inpatient mortality during the first wave of the SARS-CoV-2 pandemic: a retrospective analysis, PLoS ONE
Sandoval, Nguyen, Vahidy, Graviss, Risk factors for severity of COVID-19 in hospital patients aged 18-29 years, PLoS ONE
Sbidian, Penso, Herlemont, Botton, Baricault et al., Comment on ''Baseline use of hydroxychloroquine in systemic lupus erythematosus does not preclude SARS-CoV-2 infection and severe COVID-19'' by Konig et al. Long-term exposure to hydroxychloroquine or chloroquine and the risk of hospitalisation with COVID-19: a nationwide, observational cohort study in 54,873 exposed individuals and 155,689 matched unexposed individuals in France, Ann Rheum Dis,
doi:10.1136/annrheumdis-2020-218647
Schwartz, Boesen, Cerchiaro, Doram, Edwards et al., Assessing the efficacy and safety of hydroxychloroquine as outpatient treatment of COVID-19: a randomized controlled trial, CMAJ Open
Seet, Quek, Ooi, Sengupta, Lakshminarasappa et al., Positive impact of oral hydroxychloroquine and povidone-iodine throat spray for COVID-19 prophylaxis: an openlabel randomized trial, Int J Infect Dis
Sivapalan, Ulrik, Lapperre, Bojesen, Eklo ¨f et al., Azithromycin and hydroxychloroquine in hospitalised patients with confirmed COVID-19-a randomised double-blinded placebo-controlled trial, Eur Respir J,
doi:10.1183/13993003.00752-2021
Yao, Ye, Zhang, Cui, Huang et al., In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Clin Infect Dis
Yousefghahari, Navari, Sadeghi, Soleimaniamiri, Soleimaniamiri et al., Risk of COVID-19 infection in patients with rheumatic disease taking disease-modifying anti-rheumatic drugs, Clin Rheumatol,
doi:10.1007/s10067-021-05779-4
Zerbo, Lewis, Fireman, Goddard, Skarbinski et al., Population-based assessment of risks for severe COVID-19 disease outcomes. Influenza Other Respir Viruses
Zhang, Khullar, Wang, Steel, Wu et al., Socioeconomic variation in characteristics, outcomes, and healthcare utilization of COVID-19 patients in New York City, PLoS ONE
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