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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Mortality 27% Improvement Relative Risk c19hcq.org Gonzalez et al. HCQ for COVID-19 LATE TREATMENT Favors HCQ Favors control
The Prognostic Value of Eosinophil Recovery in COVID-19: A Multicentre, Retrospective Cohort Study on Patients Hospitalised in Spanish Hospitals
Gonzalez et al., medRxiv, doi:10.1101/2020.08.18.20172874 (Preprint)
21 Aug 2020    Source   PDF   Share   Tweet
Retrospective study focused on eosinophil recovery with 9,644 hospitalized patients in Spain, showing lower mortality for HCQ (14.7% vs 29.2%, p<0.001), and AZ (15.3% vs. 18.4%, p<0.001). With a multivariate model including potential confounding factors, HCQ and AZ are associated with lower mortality, HCQ OR 0.662, p=0.057.
Although the 27% lower mortality is not statistically significant, it is consistent with the significant 22% lower mortality [18‑27%] from meta analysis of the 228 mortality results to date.
risk of death, 26.6% lower, RR 0.73, p = 0.06, treatment 1,246 of 8,476 (14.7%), control 341 of 1,168 (29.2%), NNT 6.9, adjusted per study, odds ratio converted to relative risk.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Gonzalez et al., 21 Aug 2020, retrospective, database analysis, Spain, preprint, 25 authors.
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Late treatment
is less effective
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