Seroprevalence of COVID-19 Amongst Health Care Workers in a Tertiary Care Hospital of a Metropolitan City from India
Goenka et al.,
Seroprevalence of COVID-19 Amongst Health Care Workers in a Tertiary Care Hospital of a Metropolitan City from..,
SSRN, doi:10.2139/ssrn.3689618 (Preprint)
Study of SARS-CoV-2-IgG antibodies in 1122 health care workers in India finding 87% lower positives for adequate HCQ prophylaxis, 1.3% HCQ versus 12.3% for no HCQ prophylaxis.
Adequate prophylaxis is defined as 400mg 1/wk for >6 weeks.
risk of IgG positive, 87.2% lower, RR 0.13, p = 0.03, treatment 1 of 77 (1.3%), control 115 of 885 (13.0%), NNT 8.6, adjusted per study, odds ratio converted to relative risk.
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Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
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Goenka et al., 24 Oct 2020, retrospective, India, preprint, 11 authors.
Abstract: iew
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Seroprevalence of COVID-19 amongst health care workers in a tertiary care hospital of
a metropolitan city from India
Mahesh Kumar Goenka DM,* Director and head, Institute of Gastrosciences and Liver, Apollo
Gleneagles Hospitals, Kolkata, India
Shivaraj Afzalpurkar MD, Registrar, Institute of Gastrosciences and Liver, Apollo Gleneagles
Hospitals, Kolkata, India
Usha Goenka MD, Director and head, Department of Clinical Imaging and Interventional
Radiology, Apollo Gleneagles Hospitals, Kolkata, India
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Sudipta Sekhar Das MD, Senior consultant and head, Department of transfusion medicine,
Apollo Gleneagles Hospitals, Kolkata, India
Mohuya Mukherjee MSc, Clinical data analyst, Apollo Gleneagles Hospitals, Kolkata, India
Surabhi Jajodia MD, Consultant, Department of Clinical Imaging and Interventional
Radiology, Apollo Gleneagles Hospitals, Kolkata, India
Bhavik Bharat Shah DNB, Consultant, Institute of Gastrosciences and Liver, Apollo
Gleneagles Hospitals, Kolkata, India
Vikram Uttam Patil DNB, Registrar, Institute of Gastrosciences and Liver, Apollo Gleneagles
Hospitals, Kolkata, India
Gajanan Rodge DNB, Registrar, Institute of Gastrosciences and Liver, Apollo Gleneagles
Hospitals, Kolkata, India
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Ujjwayini Khan MD, Consultant, Department of Microbiology, Apollo Gleneagles Hospitals,
Kolkata, India
*Corresponding
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Syamasis Bandyopadhyay MD, Senior Consultant, Department of Internal Medicine, Apollo
Gleneagles Hospitals, Kolkata, India
author
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Dr. Mahesh Kumar Goenka,
Institute of Gastrosciences and Liver,
Apollo Gleneagles Hospitals Limited,
58, Canal Circular Road, Kolkata, India
Email id- mkgkolkata@gmail.com
This preprint research paper has not been peer reviewed. Electronic copy available at: https://ssrn.com/abstract=3689618
iew
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Seroprevalence of COVID-19 amongst health care workers in a tertiary
care hospital of a metropolitan city from India
Abstract
Background Seroprevalence studies for COVID-19 evaluate the extent of
undetected transmission in a defined community, with special significance among
health care workers (HCW) owing to their greater exposure and potential to
transmit.
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Methods A total of 1122 HCW (approximately 25% of the employees) of a large
tertiary care hospital in India were recruited for this cross-sectional study.
COVID PCR-positive HCW were excluded. Based on their risk-assessment,
participants were grouped into three categories. A questionnaire was
administered and they were tested for SARS-CoV-2-IgG antibodies using the
chemiluminescence.
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Findings The overall seroprevalence among workers was 11.94%, which
included 19.85% in COVID units, 11.09% in non-COVID units, and 8% in
administrative workers (p=0.007). Antibody prevalence was highest in the
department of gastroenterology (11.94%), followed by oncology (10.53%),
pathology (10.26%), emergency medicine (7.84%) and critical care medicine
(7%). Housekeeping staff, food and beverage staff, lab assistants and technicians
had higher seroprevalence rate than doctors and nurses (p < 0.0001). HCW with
a history of BCG vaccination in childhood and those who received an adequate
prophylactic dose of hydroxychloroquine (HCQ) had a lower seroprevalence as
compared to those who did not (7.31% vs. 16.8% and 1.30% vs. 11.25%
respectively).
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Interpretation BCG vaccination, HCQ prophylaxis, and the job profile influence
the seroprevalence rate in HCW. Seroprevalence rate and follow-up evaluation
of its..
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