The Need for Early Management in Patients With COVID-19
Giraud-Gatineau et al.,
The Need for Early Management in Patients With COVID-19,
Research Square, doi:rs.3.rs-251817/v1 (Preprint)
Review of early treatment of COVID-19 at IHU Méditerranée Infection in France, including HCQ+AZ treatment, comparing outcomes to those for all of France. Age-standardized mortality was lower with early treatment for all periods of the epidemic. Authors recommend early treatment for all age groups.
Giraud-Gatineau et al., 26 Feb 2021, preprint, 9 authors.
Abstract: The Need for Early Management in Patients
With COVID-19
Audrey Giraud-Gatineau
IHU Mediterranee Infection
Sébastien Cortaredona
IHU Mediterranee Infection
Jean-Christophe Lagier
IHU Mediterranee Infection
Matthieu Million
IHU Mediterranee Infection
Philippe Brouqui
IHU Mediterranee Infection
Yolande Obadia
IHU Mediterranee Infection
Patrick Peretti-Watel
ORS-PACA: Observatoire Regional de la Sante Provence-Alpes-Cote d'Azur
Didier Raoult
IHU Mediterranee Infection https://orcid.org/0000-0002-0633-5974
Stéphanie Gentile ( StephanieMarie.GENTILE@ap-hm.fr )
Aix Marseille Univ, School of medicine - La Timone Medical Campus, EA 3279: CEReSS - Health Service
Research and Quality of life Center https://orcid.org/0000-0003-3858-9503
Research article
Keywords: COVID-19, early management, patients, SARS-CoV-2, IHU Méditerranée Infection
Posted Date: February 25th, 2021
DOI: https://doi.org/10.21203/rs.3.rs-251817/v1
License: This work is licensed under a Creative Commons Attribution 4.0 International License.
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Abstract
In March 2020, the IHU Méditerranée Infection set up a screening and treatment center for patients with
COVID-19, a system that has been ultimately recommended by French public health authorities. The
recent publication of the profiles of patients hospitalized in France published by the Directorate for
Research, Studies, Evaluation and Statistics gives us the opportunity to measure the impact of this
multidisciplinary early management system coupled with screening on mortality at 90 days. Analysis of
the data shows that the system established at IHU-MI was associated with lower mortality, taking age
and sex into account. Regarding the age-standardized mortality rate, mortality rates were lower than
national data regardless of the period of the epidemic. Early management seems to have significantly
decreased the mortality rate in the under-60 age group, suggesting the importance of early management,
regardless of age. In addition, these patients had pejorative clinical criteria (high NEWS-2 score, ICU visits,
oxygen saturation below 95%) requiring hospitalization, and co-morbidities that are now known to be
aggravating factors [7]. This reinforces the need to care for all individuals, regardless of age. Early
medical care, as part of a system integrating a screening center and a day hospital, may explain the lower
mortality rates.
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