Patient-reported outcomes of neurologic and neuropsychiatric symptoms in mild COVID-19: a prospective cohort study
Aravind Ganesh, MSc Ryan E Rosentreter, Yushi Chen, MD Rahul Mehta, MD Graham A Mcleod, MD Miranda W Wan, MD Jonathan D Krett, MD Yasamin Mahjoub, MD Angela S Lee, MD Ilan S Schwartz, PhD Lawrence P Richer, MD MSc Luanne M Metz, MD Eric E Smith, MD MPH Michael D Hill
CMAJ Open, doi:10.9778/cmajo.20220248
here is growing appreciation that various neurologic and neuropsychiatric symptoms may be seen in patients with COVID-19. 1 Meta-analyses have shown a range of neurologic symptoms, including headache, myalgia and confusion, and rarer critical manifestations such as stroke and seizures, in one-third of patients admitted to hospital. 2,3 However, a major limitation to the generalizability of such frequency estimates is that published studies have generally included only patients admitted to hospital or those who were critically ill. 2, 4 Most patients with COVID-19 do not require hospital admission. The prevalence and spectrum of symptoms among communitydwelling patients with milder COVID-19 may be quite different.
Ethics approval The Conjoint Health Research Ethics Board of the University of Calgary approved the study (REB20-0790). Competing interests: Aravind Ganesh reports membership on the editorial boards of Neurology, Stroke and Neurology Clinical Practice; consulting fees and honoraria from Atheneum, MD Analytics, Figure 1 Funding: This work was supported by the Calgary Health Trust, the University of Calgary, Alberta Innovates, Alberta Health Services and the Government of Alberta. Hydroxychloroquine and matching placebo were provided by Apotex. The funders had no role in study design, interpretation or publication. Content licence: This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY-NC-ND 4.0) licence, which permits use, distribution and reproduction in any medium, provided that the original publication is properly cited, the use is noncommercial (i.e., research or educational use), and no modifications or adaptations are made. See: https://creativecommons.org/licenses/by-nc -nd/4.0/ Data sharing: Deidentified data are available on request to the corresponding author with an accompanying proposal and analysis plan. Supplemental information: For reviewer comments and the original submission of this manuscript, please see www.cmajopen.ca/content/11/4/ E696/suppl/DC1.
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