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Formulation and Evaluation of Hydroxychloroquine Sulfate Nasal Spray for SARS Covid 19 Virus

Galgate et al., Journal of Coastal Life Medicine, 11:2
May 2023  
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HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
*, now with p < 0.00000000001 from 411 studies, recognized in 46 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 79 treatments.
Formulation and testing of a HCQ nasal spray for improved bioavailability and prolonged release.
Galgate et al., 1 May 2023, peer-reviewed, 6 authors.
This PaperHCQAll
Formulation and Evaluation of Hydroxychloroquine Sulfate Nasal Spray for SARS Covid 19 Virus
Abhishek Galgate, Dr Vaibhav Vaidya, Prachi Farande, Shrutika Bhagde, Mohit Mahajan, Rohit Jadhav
Rapid spread of SARS Covid 19 turned out to be a global emergency. Covid 19 RNA virus strain is from family Coronaviridae. Phylogenetic analysis of complete viral genome revealed that virus was most closely related to SARS like coronaviruses.Symptoms of viral infection include mild infection of upper repiratory tract, viral pneumonia, respiratory failure and death. Hydroxychloroquine (HCQ) has demonstrated positive results indicating a potential role against SARS Covid 19 virus. Mechanism of action includes ;interference in endocytic pathway, blockade of sialic acid receptors, restriction of pH mediated spike (S) protein cleavage at the Angiotensin converting enzyme (ACE 2) binding site and prevention of cytokine storm.Yet clinical trials have been carried out to evaluate its abilityand turning it into a needed drug. Existing literature hints the role of Hydroxychloroquine (HCQ) sulfate in Covid 19 for obtaining a therapeutic option for the pandemic.
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