Analgesics
Antiandrogens
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Abstract
All HCQ studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19hcq.org COVID-19 treatment researchHCQHCQ (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

Formulation and Evaluation of Hydroxychloroquine Sulfate Nasal Spray for SARS Covid 19 Virus

Galgate et al., Journal of Coastal Life Medicine, 11:2
May 2023  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now known with p < 0.00000000001 from 421 studies, recognized in 42 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments. c19hcq.org
Formulation and testing of a HCQ nasal spray for improved bioavailability and prolonged release.
Galgate et al., 1 May 2023, peer-reviewed, 6 authors.
This PaperHCQAll
Formulation and Evaluation of Hydroxychloroquine Sulfate Nasal Spray for SARS Covid 19 Virus
Abhishek Galgate, Dr Vaibhav Vaidya, Prachi Farande, Shrutika Bhagde, Mohit Mahajan, Rohit Jadhav
Rapid spread of SARS Covid 19 turned out to be a global emergency. Covid 19 RNA virus strain is from family Coronaviridae. Phylogenetic analysis of complete viral genome revealed that virus was most closely related to SARS like coronaviruses.Symptoms of viral infection include mild infection of upper repiratory tract, viral pneumonia, respiratory failure and death. Hydroxychloroquine (HCQ) has demonstrated positive results indicating a potential role against SARS Covid 19 virus. Mechanism of action includes ;interference in endocytic pathway, blockade of sialic acid receptors, restriction of pH mediated spike (S) protein cleavage at the Angiotensin converting enzyme (ACE 2) binding site and prevention of cytokine storm.Yet clinical trials have been carried out to evaluate its abilityand turning it into a needed drug. Existing literature hints the role of Hydroxychloroquine (HCQ) sulfate in Covid 19 for obtaining a therapeutic option for the pandemic.
References
Andreani, Bideau, Duflot, Jardot, Rolland et al., In vitro testing of combined hydroxychloroquine and azithromycin on SARSCoV-2 shows synergistic effect, Microb Pathog, doi:10.1016/j.micpath.2020.104228
Badyal, Mahajan, Chloroquine, Can it be a Novel Drug for COVID-19, Int J Appl Basic Med Res, doi:10.4103/ijabmr.IJABMR_141_20
Bhuva, Patel, Xylometazoline nasal spray solution: novel composition used for treatment of nasal congestion
Bitter, Suter-Zimmermann, Surber, Nasal Drug Delivery in Humans, Curr Probl Dermatol. Basel, Karger
Dongala, Katari, Ettaboina, Krishnan, Tambuwala et al., In vitro Dissolution Profile at Different Biological pH Conditions of Hydroxychloroquine Sulfate Tablets Is Available for the Treatment of COVID-19, Frontiers in Molecular Biosciences
Drosten, Gunther, Preiser, Van Der Werf, Brodt et al., Identification of a novel coronavirus in patients with severe acute respiratory syndrome, N Engl J Med, doi:10.1056/NEJMoa030747
Gautret, Lagier, Parola, Hoang, Meddeb et al., Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial, Int J Antimicrob Agents, doi:10.1016/j.ijantimicag.2020.105949
Grein, Ohmagari, Shin, Diaz, Asperges et al., Compassionate Use of Remdesivir for Patients with Severe Covid-19, N Engl J Med, doi:10.1056/NEJMoa2007016
Guastalegname, Vallone, Could chloroquine /hydroxychloroquine be harmful in Coronavirus Disease 2019 (COVID-19) treatment, Clin Infect Dis, doi:10.1093/cid/ciaa321
Houtmeyers, Gosselink, Gayan-Ramirez, Decramer, Effects of drugs on mucus clearance
Huang, Wang, Li, Ren, Zhao et al., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, Lancet, doi:10.1016/S0140-6736
Kalkotwar, Review on Evaluation and Quality Control of, Nasal Spray Journal of Drug Delivery & Therapeutics
Ksiazek, Erdman, Goldsmith, Zaki, Peret et al., A novel coronavirus associated with severe acute respiratory syndrome, N Engl J Med, doi:10.1056/NEJMoa030781
Mousavizadeh, Ghasemi, Review Article on Genotype and phenotype of COVID-19: Their roles in pathogenesis, Immunology and Infection
Muhammad Adnan Shereen, Khan, Kazmi, Bashir, Siddique, COVID-19 infection: Emergence, transmission, and characteristics of human coronaviruses, Journal of Advanced Research
Ou, Liu, Lei, Li, Mi et al., Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune crossreactivity with SARS-CoV, Nat Commun, doi:10.1038/s41467-020-15562-9
Ren, Wang, Wu, Xiang, Guo et al., Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study, Chin Med J (Engl)
Satarker, Ahuja, Banerjee, Balaji, Dogra et al., Hydroxychloroquine in COVID-19: Potential Mechanism of Action Against SARS-CoV
Singh, Singh, Shaikh, Singh, Misra, Chloroquine and hydroxychloroquine in the treatment of COVID-19 with or without diabetes: A systematic search and a narrative review with a special reference to India and other developing countries, Diabetes Metab Syndr, doi:10.1016/j.dsx.2020.03.011
Tsai, Lu, San, Tsai, The Neurologic Manifestations of Coronavirus Disease
Xiao, Wang, Chang, Wang, Dong et al., None
Yao, Ye, Zhang, Cui, Huang et al., In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Clin Infect Dis, doi:10.1093/cid/ciaa237
Zaki, Van Boheemen, Bestebroer, Osterhaus, Fouchier, Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia, N Engl J Med, doi:10.1056/NEJMoa1211721
Zhu, Zhang, Li, Yang, Song, A Novel Coronavirus from Patients with Pneumonia in China, N Engl J Med, doi:10.1056/NEJMoa2001017
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit