Risk Factors for Infection and Health Impacts of the COVID-19 Pandemic in People with Autoimmune Diseases
Fitzgerald et al.,
Risk Factors for Infection and Health Impacts of the COVID-19 Pandemic in People with Autoimmune Diseases,
medRxiv, doi:10.1101/2021.02.03.21251069 (Preprint)
Retrospective 4666 people with autoimmune or inflammatory conditions, showing HCQ adjusted risk of COVID-19 OR 0.91 [0.68-1.23]. Results are not adjusted for the significantly different risk of COVID-19 depending on the type and severity of autoimmune or inflammatory condition.
This study is excluded in the after exclusion results of meta
analysis:
not fully adjusting for the baseline risk differences within systemic autoimmune patients.
risk of case, 8.5% lower, RR 0.91, p = 0.54, treatment 65 of 1,072 (6.1%), control 200 of 3,594 (5.6%), adjusted per study, odds ratio converted to relative risk.
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Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
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Fitzgerald et al., 5 Feb 2021, retrospective, USA, preprint, 34 authors.
Abstract: medRxiv preprint doi: https://doi.org/10.1101/2021.02.03.21251069; this version posted February 5, 2021. The copyright holder for this preprint
(which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
It is made available under a CC-BY-NC-ND 4.0 International license .
Fitzgerald et al. 1
RISK FACTORS FOR INFECTION AND HEALTH IMPACTS OF THE COVID-19 PANDEMIC IN PEOPLE WITH
AUTOIMMUNE DISEASES
Kathryn C. Fitzgerald1,2, ScD, Christopher A. Mecoli3, MD, MHS, Morgan Douglas1, BS, Samantha Harris1,
BS, Berna Aravidis1, BS, Jemima Albayda3, MD, Elias S. Sotirchos1, MD, Ahmet Hoke1, MD, PhD, AnaMaria Orbai3, MD, MHS, Michelle Petri1, MD, MPH, Lisa Christopher-Stine3, MD, Alan N. Baer, MD3, Julie
J. Paik3, MD, MHS, Brittany L. Adler3, MD, Eleni Tiniakou3, MD, Homa Timlin3, MD, MSc, Pavan Bhargava1,
MD, Scott D. Newsome1, DO, Arun Venkatesan1, MD, PhD, Vinay Chaudhry1, MD, Thomas E. Lloyd1, MD,
PhD, Carlos A. Pardo1, MD, Barney J. Stern1, MD, Mark Lazarev4, MD, Brindusa Truta4, MD, MAS, Shiv
Saidha1, MBBCh, Edward S. Chen5, MD, Michelle Sharp5, MD, MHS, Nisha Gilotra6, MD, Edward K.
Kasper6, MD, Allan C. Gelber, MD, MPH, PhD2,3, Clifton O. Bingham III3, MD, Ami A. Shah3, MD, MHS,
Ellen M. Mowry1,2, MD, MCR
1
Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
3
Division of Rheumatology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD,
USA
4
Division of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins School of
Medicine, Baltimore, MD, USA
5
Division of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD,
USA
6
Department of Cardiology, Johns Hopkins School of Medicine, Baltimore, MD, USA
2
Title: 105 characters
Abstract: 275 words
Text: 3591
References: 30
Tables: 4
Figures: 2
eTables: 8
Author Email Addresses:
fitzgerald@jhmi.edu
cmecoli1@jhmi.edu
mdougl18@jhmi.edu
sharr141@jhmi.edu
baravid1@jhmi.edu
jalbayd1@jhmi.edu
ahoke@jhmi.edu
ess@jhmi.edu
aorbai1@jhmi.edu
mpetri@jhmi.edu
lchrist4@jhmi.edu
alanbaer@jhmi.edu
jpaik1@jhmi.edu
brit.adler@jhmi.edu
NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice.
medRxiv preprint doi: https://doi.org/10.1101/2021.02.03.21251069; this version posted February 5, 2021. The copyright holder for this preprint
(which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
It is made available under a CC-BY-NC-ND 4.0 International license .
Fitzgerald et al. 2
etiniak1@jhmi.edu
htimlin1@jhmi.edu
pbharga2@jhmi.edu
snewsom2@jhmi.edu
avenkat2@jhmi.edu
vchaudh@jhmi.edu
tlloyd4@jhmi.edu
cpardov1@jhmi.edu
bstern6@jhmi.edu
mlazare1@jhmi.edu
btruta1@jhmi.edu
ssaidha2@jhmi.edu
chenedwa@jhmi.edu
msharp5@jhmi.edu
naggarw2@jhmi.edu
ekasper@jhmi.edu
agelber@jhmi.edu
cbingha2@jhmi.edu
ami.shah@jhmi.edu
emowry1@jhmi.edu
Corresponding author:
Kathryn C Fitzgerald
fitzgerald@jhmi.edu
600 N Wolfe St
Pathology 627
Baltimore MD, 21287
medRxiv preprint doi: https://doi.org/10.1101/2021.02.03.21251069; this version posted February 5, 2021. The copyright holder for this preprint
(which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in..
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