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Home   COVID-19 treatment studies for Hydroxychloroquine  COVID-19 treatment studies for HCQ  C19 studies: HCQ  HCQ   Select treatmentSelect treatmentTreatmentsTreatments
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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Δt7-12 ΔCt improvement 81% Improvement Relative Risk Δt<7 ΔCt improvement 24% Δt>12 ΔCt improvement -15% c19hcq.org Faíco-Filho et al. HCQ for COVID-19 LATE TREATMENT Favors HCQ Favors control
No benefit of hydroxychloroquine on SARS-CoV-2 viral load reduction in non-critical hospitalized patients with COVID-19
Faíco-Filho et al., Braz J Microbiol, doi:10.1007/s42770-020-00395-x (date from earlier preprint)
21 Jun 2020    Source   PDF   Share   Tweet
Viral load comparison for 34 HCQ and 32 control patients hospitalized with moderate COVID-19. All patients recovered limiting the room for beneficial effects.
While not achieving statistical significance, results show faster recovery with HCQ. The greatest benefit is seen mid-recovery as expected for an effective treatment:
Δt7-12: 81% improvement with HCQ
Δt<7: 24% improvement with HCQ
For Δt>12, everyone has recovered so there is no room for improvement. Since the HCQ group started slightly higher the improvement is slightly less. Most participants have also dropped out by this test, with only 6 HCQ and 9 control remaining (also suggesting HCQ patients recovered faster).
Δt7-12 ΔCt improvement, 80.8% lower, relative rate 0.19, p = 0.40, treatment 34, control 32.
Δt<7 ΔCt improvement, 24.0% lower, relative rate 0.76, p = 0.36, treatment 34, control 32.
Δt>12 ΔCt improvement, 15.0% higher, relative rate 1.15, p = 0.52, treatment 34, control 32.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Faíco-Filho et al., 21 Jun 2020, prospective, Brazil, peer-reviewed, median age 58.0, 6 authors.
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Late treatment
is less effective
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