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0 0.5 1 1.5 2+ Hospitalization 64% Improvement Relative Risk c19hcq.org Esper et al. HCQ for COVID-19 EARLY TREATMENT Favors HCQ Favors control
Empirical treatment with hydroxychloroquine and azithromycin for suspected cases of COVID-19 followed-up by telemedicine
Esper et al., Prevent Senior Institute, São Paulo, Brazil (Preprint)
15 Apr 2020    Source   PDF   Share   Tweet
636 patients. HCQ+AZ reduced hospitalization 79% when used within 7 days (65% overall). Non-randomized.
risk of hospitalization, 64.0% lower, RR 0.36, p = 0.02, treatment 8 of 412 (1.9%), control 12 of 224 (5.4%), NNT 29.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Esper et al., 15 Apr 2020, prospective, Brazil, preprint, 15 authors, average treatment delay 5.2 days, dosage 800mg day 1, 400mg days 2-7, this trial uses multiple treatments in the treatment arm (combined with AZ) - results of individual treatments may vary.
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