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COVID-19 outcomes in patients with antiphospholipid syndrome: a retrospective cohort study

Erden et al., Bratislava Medical Journal, doi:10.4149/BLL_2022_018
Jan 2022  
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Mortality -150% Improvement Relative Risk Hospitalization 75% HCQ for COVID-19  Erden et al.  Prophylaxis Is pre-exposure prophylaxis with HCQ beneficial for COVID-19? Retrospective 9 patients in Turkey No significant difference in outcomes seen Erden et al., Bratislava Medical J., Jan 2022 FavorsHCQ Favorscontrol 0 0.5 1 1.5 2+
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
*, now with p < 0.00000000001 from 411 studies, recognized in 46 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 79 treatments.
Retrospective 9 COVID-19 patients with antiphospholipid syndrome in Turkey, showing no significant differences based on existing HCQ treatment.
This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details.
risk of death, 150.0% higher, RR 2.50, p = 1.00, treatment 1 of 6 (16.7%), control 0 of 3 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm).
risk of hospitalization, 75.0% lower, RR 0.25, p = 0.23, treatment 1 of 6 (16.7%), control 2 of 3 (66.7%), NNT 2.0.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Erden et al., 23 Jan 2022, retrospective, Turkey, peer-reviewed, 11 authors.
This PaperHCQAll
COVID-19 outcomes in patients with antiphospholipid syndrome: a retrospective cohort study
A Erden, O Karakas, B Armagan, S C Guven, B Ozdemir, E Atalar, H Apaydin, E Usul, I Ates, A Omma, O Kucuksahin
Bratislava Medical Journal, doi:10.4149/bll_2022_018
BACKGROUND: Aim of this study is to investigate COVID-19 outcomes in patients with antiphospholipid syndrome (APS). METHODS: A retrospective cohort was formed from APS patients. Patients were screened for a record of positive SARS-CoV 2 PCR. In PCR-positive patients, clinical data and information regarding COVID-19 outcomes were collected from medical records. RESULTS: A positive PCR test was detected in 9/53 APS patients, while 66.7 %, 33.3 % and 11.1 % of APS patients with COVID-19 were under hydroxychloroquine, LMWH or warfarin, and acetylsalicylic acid, respectively. There were 3/9 patients found to be hospitalized and one died. No new thrombotic event was reported in any of the patients during COVID-19 infection. CONCLUSION: Baseline use of hydroxychloroquine, antiaggregants and anticoagulants may be associated with an absence of new thrombotic event (Tab. 2, Ref. 33).
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