Di Castelnuovo: Disentangling the Association of Hydroxychloroquine Treatment with Mortality in Covid-19 Hospitalized Patients through Hierarchical Clustering [HCQ]

Disentangling the Association of Hydroxychloroquine Treatment with Mortality in Covid-19 Hospitalized Patients through Hierarchical Clustering

Di Castelnuovo et al., Journal of Healthcare Engineering, doi:10.1155/2021/5556207 (date from earlier preprint)

Di Castelnuovo et al., Disentangling the Association of Hydroxychloroquine Treatment with Mortality in Covid-19 Hospitalized Patients.., Journal of Healthcare Engineering, doi:10.1155/2021/5556207 (date from earlier preprint)

Jan 2021 Source PDF

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Retrospective 4,396 hospitalized patients in Italy showing significantly lower mortality with HCQ treatment, and identifying greater efficacy for a subgroup of patients in clustering analysis.

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risk of death, 40.0% lower, RR 0.60, p < 0.001, treatment 3,270, control 1,000, odds ratio converted to relative risk, multivariate Cox proportional hazards model 4, control prevalence approximated with overall prevalence.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Di Castelnuovo et al., 29 Jan 2021, retrospective, Italy, peer-reviewed, 112 authors.

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Abstract: Hindawi Journal of Healthcare Engineering Volume 2021, Article ID 5556207, 10 pages https://doi.org/10.1155/2021/5556207 Research Article Disentangling the Association of Hydroxychloroquine Treatment with Mortality in Covid-19 Hospitalized Patients through Hierarchical Clustering Augusto Di Castelnuovo ,1 Alessandro Gialluisi,2 Andrea Antinori,3 Nausicaa Berselli,4 Lorenzo Blandi,5 Marialaura Bonaccio,2 Raﬀaele Bruno,6,7 Roberto Cauda,8,9 Simona Costanzo,2 Giovanni Guaraldi,10 Lorenzo Menicanti,11 Marco Mennuni,12 Ilaria My,13 Giustino Parruti,14 Giuseppe Patti,12 Stefano Perlini,15,16 Francesca Santilli,17 Carlo Signorelli,18 Giulio Stefanini,13 Alessandra Vergori,19 Walter Ageno,20 Antonella Agodi,21 Piergiuseppe Agostoni,22,23 Luca Aiello,24 Samir Al Moghazi,25 Rosa Arboretti,26 Filippo Aucella,27 Greta Barbieri,28 Martina Barchitta,29 Paolo Bonfanti,30,31 Francesco Cacciatore,32 Lucia Caiano,20 Francesco Cannata,13 Laura Carrozzi,33 Antonio Cascio,34 Giacomo Castiglione,35 Arturo Ciccullo,8 Antonella Cingolani,8,9 Francesco Cipollone,17 Claudia Colomba,34 Crizia Colombo,12 Annalisa Crisetti,27 Francesca Crosta,14 Gian Battista Danzi,36 Damiano D’Ardes,17 Katleen de Gaetano Donati,8,9 Francesco Di Gennaro,37 Giuseppe Di Tano,36 Gianpiero D’Oﬃzi,38 Francesco Maria Fusco,39 Carlo Gaudiosi,40 Ivan Gentile,41 Francesco Gianfagna1,20 Gabriele Giuliano,8 Emauele Graziani,42 Gabriella Guarnieri,43 Valerio Langella,44 Giovanni Larizza,45 Armando Leone,46 Gloria Maccagni,36 Federica Magni,20 Stefano Maitan,24 Sandro Mancarella,47 Rosa Manuele,48 Massimo Mapelli,22,23 Riccardo Maragna,22,23 Rossella Marcucci,49 Giulio Maresca,44 Silvia Marongiu,50 Claudia Marotta,37 Lorenzo Marra,46 Franco Mastroianni,45 Alessandro Mengozzi,51 Marianna Meschiari,10 Jovana Milic,10 Filippo Minutolo,52 Roberta Mussinelli,16 Cristina Mussini,10 Maria Musso,53 Anna Odone,5 Marco Olivieri,54 Antonella Palimodde,50 Emanuela Pasi,42 Raﬀaele Pesavento,55 Francesco Petri,30 Carlo A Pivato,13 Venerino Poletti,56,57 Claudia Ravaglia,56 Giulia Righetti,45 Andrea Rognoni,12 Marco Rossato,55 Ilaria Rossi,17 Marianna Rossi,30 Anna Sabena,15 Francesco Salinaro,15 Vincenzo Sangiovanni,39 Carlo Sanrocco,14 Nicola Schiano Moriello,41 Laura Scorzolini,58 Raﬀaella Sgariglia,47 Paola Giustina Simeone,14 Michele Spinicci,49 Enrica Tamburrini,8 Carlo Torti,59 Enrico Maria Trecarichi,59 Roberto Vettor,55 Andrea Vianello,43 Marco Vinceti,4,60 Agostino Virdis,51 Raﬀaele De Caterina,33 and Licia Iacoviello 2,20 1 Mediterranea Cardiocentro, Napoli, Italy Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy 3 UOC Immunodeﬁcienze Virali, National Institute for Infectious Diseases “L. Spallanzani” IRCCS, Rome, Italy 4 Section of Public Health, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy 5 Università di Pavia, Pavia, Italy 6 Division of Infectious Diseases I, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy 7 Department of Clinical, Surgical Diagnostic and Paediatric Sciences, University of Pavia, Pavia, Italy 8 Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy 2 2 Journal of Healthcare Engineering 9 Università Cattolica Del Sacro Cuore- Dipartimento di Sicurezza e Bioetica Sede di Roma, Roma, Italy Infectious Disease Unit, Department of Surgical, Medical Dental and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy 11 IRCCS Policlinico San Donato,..

Late treatment
is less effective

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