Excessive lysosomal ion-trapping of hydroxychloroquine and azithromycin

DOI record: { "DOI": "10.1016/j.ijantimicag.2020.106007", "ISSN": [ "0924-8579" ], "URL": "http://dx.doi.org/10.1016/j.ijantimicag.2020.106007", "alternative-id": [ "S0924857920301655" ], "article-number": "106007", "assertion": [ { "label": "This article is maintained by", "name": "publisher", "value": "Elsevier" }, { "label": "Article Title", "name": "articletitle", "value": "Excessive lysosomal ion-trapping of hydroxychloroquine and azithromycin" }, { "label": "Journal Title", "name": "journaltitle", "value": "International Journal of Antimicrobial Agents" }, { "label": "CrossRef DOI link to publisher maintained version", "name": "articlelink", "value": "https://doi.org/10.1016/j.ijantimicag.2020.106007" }, { "label": "Content Type", "name": "content_type", "value": "article" }, { "label": "Copyright", "name": "copyright", "value": "© 2020 Elsevier B.V. and International Society of Chemotherapy. All rights reserved." } ], "author": [ { "ORCID": "http://orcid.org/0000-0003-4016-1370", "affiliation": [], "authenticated-orcid": false, "family": "Derendorf", "given": "Hartmut", "sequence": "first" } ], "container-title": "International Journal of Antimicrobial Agents", "container-title-short": "International Journal of Antimicrobial Agents", "content-domain": { "crossmark-restriction": true, "domain": [ "clinicalkey.jp", "clinicalkey.com", "clinicalkey.es", "clinicalkey.com.au", "clinicalkey.fr", "elsevier.com", "sciencedirect.com" ] }, "created": { "date-parts": [ [ 2020, 5, 7 ] ], "date-time": "2020-05-07T08:45:30Z", "timestamp": 1588841130000 }, "deposited": { "date-parts": [ [ 2020, 6, 23 ] ], "date-time": "2020-06-23T05:03:19Z", "timestamp": 1592888599000 }, "indexed": { "date-parts": [ [ 2024, 4, 30 ] ], "date-time": "2024-04-30T06:31:01Z", "timestamp": 1714458661901 }, "is-referenced-by-count": 37, "issue": "6", "issued": { "date-parts": [ [ 2020, 6 ] ] }, "journal-issue": { "issue": "6", "published-print": { "date-parts": [ [ 2020, 6 ] ] } }, "language": "en", "license": [ { "URL": "https://www.elsevier.com/tdm/userlicense/1.0/", "content-version": "tdm", "delay-in-days": 0, "start": { "date-parts": [ [ 2020, 6, 1 ] ], "date-time": "2020-06-01T00:00:00Z", "timestamp": 1590969600000 } } ], "link": [ { "URL": "https://api.elsevier.com/content/article/PII:S0924857920301655?httpAccept=text/xml", "content-type": "text/xml", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "https://api.elsevier.com/content/article/PII:S0924857920301655?httpAccept=text/plain", "content-type": "text/plain", "content-version": "vor", "intended-application": "text-mining" } ], "member": "78", "original-title": [], "page": "106007", "prefix": "10.1016", "published": { "date-parts": [ [ 2020, 6 ] ] }, "published-print": { "date-parts": [ [ 2020, 6 ] ] }, "publisher": "Elsevier BV", "reference": [ { "DOI": "10.1016/j.ijantimicag.2020.105949", "article-title": "Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial", "author": "Gautret", "doi-asserted-by": "crossref", "journal-title": "Int J Antimicrob Agents", "key": "10.1016/j.ijantimicag.2020.106007_bib0001", "year": "2020" }, { "DOI": "10.1016/j.tmaid.2020.101663", "article-title": "Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: A pilot observational study", "author": "Gautret", "doi-asserted-by": "crossref", "journal-title": "Travel Med Infect Dis", "key": "10.1016/j.ijantimicag.2020.106007_bib0002", "year": "2020" }, { "DOI": "10.1016/j.medmal.2020.03.006", "article-title": "No evidence of rapid antiviral clearance or clinical benefit with the combination of hydroxychloroquine and azithromycin in patients with severe COVID-19 infection", "author": "Molina", "doi-asserted-by": "crossref", "journal-title": "Med Mal Infect", "key": "10.1016/j.ijantimicag.2020.106007_bib0003", "year": "2020" }, { "DOI": "10.1503/cmaj.200528", "article-title": "Safety considerations with chloroquine, hydroxychloroquine and azithromycin in the management of SARS-CoV-2 infection", "author": "Juurlink", "doi-asserted-by": "crossref", "journal-title": "CMAJ", "key": "10.1016/j.ijantimicag.2020.106007_bib0004", "year": "2020" }, { "DOI": "10.1128/AAC.01723-09", "article-title": "Cellular pharmacokinetics of the novel biaryloxazolidinone radezolid in phagocytic cells: studies with macrophages and polymorphonuclear neutrophils", "author": "Lemaire", "doi-asserted-by": "crossref", "first-page": "2540", "issue": "6", "journal-title": "Antimicrob Agents Chemother", "key": "10.1016/j.ijantimicag.2020.106007_bib0005", "volume": "54", "year": "2010" }, { "DOI": "10.1016/j.toxrep.2014.10.019", "article-title": "Chloroquine and hydroxychloroquine binding to melanin: Some possible consequences for pathologies", "author": "Schroeder", "doi-asserted-by": "crossref", "first-page": "963", "journal-title": "Toxicol Rep", "key": "10.1016/j.ijantimicag.2020.106007_bib0006", "volume": "1", "year": "2014" }, { "DOI": "10.1124/dmd.112.050054", "article-title": "Lysosomal sequestration (trapping) of lipophilic amine (cationic amphiphilic) drugs in immortalized human hepatocytes (Fa2N-4 cells)", "author": "Kazmi", "doi-asserted-by": "crossref", "first-page": "897", "issue": "4", "journal-title": "Drug Metab Dispos", "key": "10.1016/j.ijantimicag.2020.106007_bib0007", "volume": "41", "year": "2013" }, { "DOI": "10.1002/bod.2510090602", "article-title": "The potential role of lysosomes in tissue distribution of weak bases", "author": "MacIntyre", "doi-asserted-by": "crossref", "first-page": "513", "issue": "6", "journal-title": "Biopharm Drug Dispos", "key": "10.1016/j.ijantimicag.2020.106007_bib0008", "volume": "9", "year": "1988" }, { "DOI": "10.1111/j.1365-2125.1988.tb05281.x", "article-title": "A dose-ranging study of the pharmacokinetics of hydroxy-chloroquine following intravenous administration to healthy volunteers", "author": "Tett", "doi-asserted-by": "crossref", "first-page": "303", "issue": "3", "journal-title": "Br J Clin Pharmacol", "key": "10.1016/j.ijantimicag.2020.106007_bib0009", "volume": "26", "year": "1988" }, { "article-title": "Accumulation, release and subcellular localization of azithromycin in phagocytic and non-phagocytic cells in culture", "author": "Carlier", "first-page": "211", "issue": "5-6", "journal-title": "Int J Tissue React", "key": "10.1016/j.ijantimicag.2020.106007_bib0010", "volume": "16", "year": "1994" }, { "DOI": "10.1006/excr.2002.5613", "article-title": "Azithromycin, a lysosomotropic antibiotic, has distinct effects on fluid-phase and receptor-mediated endocytosis, but does not impair phagocytosis in J774 macrophages", "author": "Tyteca", "doi-asserted-by": "crossref", "first-page": "86", "issue": "1", "journal-title": "Exp Cell Res", "key": "10.1016/j.ijantimicag.2020.106007_bib0011", "volume": "281", "year": "2002" }, { "DOI": "10.1078/0171-9335-00180", "article-title": "Azithromycin, a lysosomotropic antibiotic, impairs fluid-phase pinocytosis in cultured fibroblasts", "author": "Tyteca", "doi-asserted-by": "crossref", "first-page": "466", "issue": "7", "journal-title": "Eur J Cell Biol", "key": "10.1016/j.ijantimicag.2020.106007_bib0012", "volume": "80", "year": "2001" }, { "DOI": "10.1016/S0014-2999(96)00552-3", "article-title": "Interaction of the macrolide azithromycin with phospholipids. I. Inhibition of lysosomal phospholipase A1 activity", "author": "Van Bambeke", "doi-asserted-by": "crossref", "first-page": "203", "issue": "1-2", "journal-title": "Eur J Pharmacol", "key": "10.1016/j.ijantimicag.2020.106007_bib0013", "volume": "314", "year": "1996" }, { "DOI": "10.1128/AAC.02904-14", "article-title": "Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects", "author": "Zheng", "doi-asserted-by": "crossref", "first-page": "6675", "issue": "11", "journal-title": "Antimicrob Agents Chemother", "key": "10.1016/j.ijantimicag.2020.106007_bib0014", "volume": "58", "year": "2014" }, { "article-title": "Gentamicin-induced lysosomal phospholipidosis in cultured rat fibroblasts. Quantitative ultrastructural and biochemical study", "author": "Aubert-Tulkens", "first-page": "481", "issue": "4", "journal-title": "Lab Invest", "key": "10.1016/j.ijantimicag.2020.106007_bib0015", "volume": "40", "year": "1979" }, { "DOI": "10.1016/S108495210200054X", "article-title": "Introduction: lysosome-related organelles", "author": "Cutler", "doi-asserted-by": "crossref", "first-page": "261", "issue": "4", "journal-title": "Semin Cell Dev Biol", "key": "10.1016/j.ijantimicag.2020.106007_bib0016", "volume": "13", "year": "2002" }, { "DOI": "10.1083/jcb.68.3.665", "article-title": "Membrane flow during pinocytosis. A stereologic analysis", "author": "Steinman", "doi-asserted-by": "crossref", "first-page": "665", "issue": "3", "journal-title": "J Cell Biol", "key": "10.1016/j.ijantimicag.2020.106007_bib0017", "volume": "68", "year": "1976" }, { "key": "10.1016/j.ijantimicag.2020.106007_bib0018", "unstructured": "Pfizer. Zithromax product information. 2019; Available from:https://labeling.pfizer.com/ShowLabeling.aspx?id=511." }, { "DOI": "10.1016/j.ijantimicag.2010.01.023", "article-title": "Class-dependent relevance of tissue distribution in the interpretation of anti-infective pharmacokinetic/pharmacodynamic indices", "author": "Barbour", "doi-asserted-by": "crossref", "first-page": "431", "issue": "5", "journal-title": "Int J Antimicrob Agents", "key": "10.1016/j.ijantimicag.2020.106007_bib0019", "volume": "35", "year": "2010" }, { "DOI": "10.1002/jps.2600770303", "article-title": "role of lysosomes in hepatic accumulation of chloroquine", "author": "MacIntyre", "doi-asserted-by": "crossref", "first-page": "196", "issue": "3", "journal-title": "J Pharm Sci", "key": "10.1016/j.ijantimicag.2020.106007_bib0020", "volume": "77", "year": "1988" }, { "DOI": "10.1083/jcb.63.2.430", "article-title": "Protein degradation in cultured cells. II. The uptake of chloroquine by rat fibroblasts and the inhibition of cellular protein degradation and cathepsin B1", "author": "Wibo", "doi-asserted-by": "crossref", "first-page": "430", "issue": "2 Pt 1", "journal-title": "J Cell Biol", "key": "10.1016/j.ijantimicag.2020.106007_bib0021", "volume": "63", "year": "1974" }, { "DOI": "10.1083/jcb.90.3.665", "article-title": "Effect of weak bases on the intralysosomal pH in mouse peritoneal macrophages", "author": "Poole", "doi-asserted-by": "crossref", "first-page": "665", "issue": "3", "journal-title": "J Cell Biol", "key": "10.1016/j.ijantimicag.2020.106007_bib0022", "volume": "90", "year": "1981" }, { "DOI": "10.4269/ajtmh.2006.74.407", "article-title": "Lack of a pharmacokinetic interaction between azithromycin and chloroquine", "author": "Cook", "doi-asserted-by": "crossref", "first-page": "407", "issue": "3", "journal-title": "Am J Trop Med Hyg", "key": "10.1016/j.ijantimicag.2020.106007_bib0023", "volume": "74", "year": "2006" }, { "DOI": "10.1128/AAC.46.8.2518-2524.2002", "article-title": "Assessment of azithromycin in combination with other antimalarial drugs against Plasmodium falciparum in vitro", "author": "Ohrt", "doi-asserted-by": "crossref", "first-page": "2518", "issue": "8", "journal-title": "Antimicrob Agents Chemother", "key": "10.1016/j.ijantimicag.2020.106007_bib0024", "volume": "46", "year": "2002" }, { "DOI": "10.1016/j.ijantimicag.2020.105932", "article-title": "Chloroquine and hydroxychloroquine as available weapons to fight COVID-19", "author": "Colson", "doi-asserted-by": "crossref", "issue": "4", "journal-title": "Int J Antimicrob Agents", "key": "10.1016/j.ijantimicag.2020.106007_bib0025", "volume": "55", "year": "2020" }, { "DOI": "10.1016/j.ijantimicag.2020.105923", "article-title": "Chloroquine for the 2019 novel coronavirus SARS-CoV-2", "author": "Colson", "doi-asserted-by": "crossref", "issue": "3", "journal-title": "Int J Antimicrob Agents", "key": "10.1016/j.ijantimicag.2020.106007_bib0026", "volume": "55", "year": "2020" }, { "DOI": "10.1016/j.ijantimicag.2007.05.015", "article-title": "Recycling of chloroquine and its hydroxyl analogue to face bacterial, fungal and viral infections in the 21st century", "author": "Rolain", "doi-asserted-by": "crossref", "first-page": "297", "issue": "4", "journal-title": "Int J Antimicrob Agents", "key": "10.1016/j.ijantimicag.2020.106007_bib0027", "volume": "30", "year": "2007" }, { "DOI": "10.1016/j.ijantimicag.2020.105938", "doi-asserted-by": "crossref", "key": "10.1016/j.ijantimicag.2020.106007_bib0028", "unstructured": "Devaux CA, Rolain JM, Colson P, Raoult D. New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?Int J Antimicrob Agents2020:105938." }, { "DOI": "10.1128/JVI.78.11.5642-5650.2004", "article-title": "pH-dependent entry of severe acute respiratory syndrome coronavirus is mediated by the spike glycoprotein and enhanced by dendritic cell transfer through DC-SIGN", "author": "Yang", "doi-asserted-by": "crossref", "first-page": "5642", "issue": "11", "journal-title": "J Virol", "key": "10.1016/j.ijantimicag.2020.106007_bib0029", "volume": "78", "year": "2004" }, { "DOI": "10.1016/j.virol.2011.02.020", "article-title": "Different host cell proteases activate the SARS-coronavirus spike-protein for cell-cell and virus-cell fusion", "author": "Simmons", "doi-asserted-by": "crossref", "first-page": "265", "issue": "2", "journal-title": "Virology", "key": "10.1016/j.ijantimicag.2020.106007_bib0030", "volume": "413", "year": "2011" }, { "DOI": "10.1371/journal.pone.0091293", "article-title": "Efficacy of combination therapy with oseltamivir phosphate and azithromycin for influenza: a multicenter, open-label, randomized study", "author": "Kakeya", "doi-asserted-by": "crossref", "first-page": "e91293", "issue": "3", "journal-title": "PLoS One", "key": "10.1016/j.ijantimicag.2020.106007_bib0031", "volume": "9", "year": "2014" }, { "DOI": "10.1155/2012/649570", "article-title": "Macrolide therapy in respiratory viral infections", "author": "Min", "doi-asserted-by": "crossref", "journal-title": "Mediators Inflamm", "key": "10.1016/j.ijantimicag.2020.106007_bib0032", "volume": "2012", "year": "2012" }, { "article-title": "PLAQUENIL® hydroxychloroquine sulfate tablets", "journal-title": "Product Information", "key": "10.1016/j.ijantimicag.2020.106007_bib0033", "year": "2015" }, { "DOI": "10.4269/ajtmh.2007.77.929", "article-title": "Azithromycin/chloroquine combination does not increase cardiac instability despite an increase in monophasic action potential duration in the anesthetized guinea pig", "author": "Fossa", "doi-asserted-by": "crossref", "first-page": "929", "issue": "5", "journal-title": "Am J Trop Med Hyg", "key": "10.1016/j.ijantimicag.2020.106007_bib0034", "volume": "77", "year": "2007" }, { "DOI": "10.1093/cid/ciaa237", "article-title": "In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)", "author": "Yao", "doi-asserted-by": "crossref", "journal-title": "Clin Infect Dis", "key": "10.1016/j.ijantimicag.2020.106007_bib0035", "year": "2020" }, { "article-title": "Design and optimization of dosage regimens: pharmacokinetic data", "author": "Thummel", "key": "10.1016/j.ijantimicag.2020.106007_bib0036", "series-title": "Goodman & Gilman's The Pharmacological Basis of Therapeutics", "year": "2006" } ], "reference-count": 36, "references-count": 36, "relation": {}, "resource": { "primary": { "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0924857920301655" } }, "score": 1, "short-title": [], "source": "Crossref", "subject": [], "subtitle": [], "title": "Excessive lysosomal ion-trapping of hydroxychloroquine and azithromycin", "type": "journal-article", "update-policy": "http://dx.doi.org/10.1016/elsevier_cm_policy", "volume": "55" }