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Long-term clinical follow-up of patients suffering from moderate-to-severe COVID-19 infection: a monocentric prospective observational cohort study

Darcis et al., International Journal of Infectious Diseases, doi:10.1016/j.ijid.2021.07.016
Aug 2021  
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PASC 32% Improvement Relative Risk HCQ for COVID-19  Darcis et al.  LATE TREATMENT Is late treatment with HCQ beneficial for COVID-19? Prospective study of 199 patients in Belgium (Mar - Oct 2020) Lower PASC with HCQ (not stat. sig., p=0.58) c19hcq.org Darcis et al., Int. J. Infectious Dise.., Aug 2021 FavorsHCQ Favorscontrol 0 0.5 1 1.5 2+
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now with p < 0.00000000001 from 417 studies, recognized in 46 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,800+ studies for 102 treatments. c19hcq.org
Prospective observational study of 199 hospitalized COVID-19 patients in Belgium showing a high prevalence of persistent symptoms including dyspnea and fatigue at 6 months after discharge. Pulmonary function tests revealed reduced diffusion capacity, and CT scans showed a high prevalence of persistent lung abnormalities at 3 months, mainly ground glass opacities. Logistic regression shows lower risk of persistent symptoms with HCQ treatment, without statistical significance.
risk of PASC, 32.0% lower, OR 0.68, p = 0.58, treatment 164, control 35, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Darcis et al., 31 Aug 2021, prospective, Belgium, peer-reviewed, mean age 60.5, 17 authors, study period 2 March, 2020 - 1 October, 2020. Contact: gdarcis@chuliege.be.
This PaperHCQAll
Long-term clinical follow-up of patients suffering from moderate-to-severe COVID-19 infection: a monocentric prospective observational cohort study
Gilles Darcis, Antoine Bouquegneau, Nathalie Maes, Marie Thys, Monique Henket, Florence Labye, Anne-Françoise Rousseau, Perrine Canivet, Colin Desir, Doriane Calmes, Raphael Schils, Sophie De Worm, Philippe Léonard, Paul Meunier, Michel Moutschen, Renaud Louis, Julien Guiot
International Journal of Infectious Diseases, doi:10.1016/j.ijid.2021.07.016
Objectives: Various symptoms and considerable organ dysfunction persist following infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Uncertainty remains about the potential midand long-term health sequelae. This prospective study of patients hospitalized with coronavirus disease 2019 in Liège University Hospital, Belgium aimed to determine the persistent consequences of COVID-19. Methods: Patients admitted to the University Hospital of Liège with moderate-to-severe confirmed COVID-19, discharged between 2 March and 1 October 2020, were recruited prospectively. Follow-up at 3 and 6 months after hospital discharge included demographic and clinical data, biological data, pulmonary function tests (PFTs) and high-resolution computed tomography (CT) scans of the chest. Results: In total, 199 individuals were included in the analysis. Most patients received oxygen supplementation (80.4%). Six months after discharge, 47% and 32% of patients still had exertional dyspnoea and fatigue. PFTs at 3-month follow-up revealed a reduced diffusion capacity of carbon monoxide (mean 71.6 ± 18.6%), and this increased significantly at 6-month follow-up ( P < 0.0 0 01). Chest CT scans showed a high prevalence (68.9% of the cohort) of persistent abnormalities, mainly ground glass opacities. Duration of hospitalization, intensive care unit admission and mechanical ventilation were not associated with the persistence of symptoms 3 months after discharge. Conclusion: The prevalence of persistent symptoms following hospitalization with COVID-19 is high and stable for up to 6 months after discharge. However, biological, functional and iconographic abnormalities improved significantly over time.
Conflict of interest statement None declared. Supplementary materials Supplementary material associated with this article can be found, in the online version, at doi:10.1016/j.ijid.2021.07.016 .
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Late treatment
is less effective
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