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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Time to clinical recovery 20% Improvement Relative Risk Time to clinical reco.. (b) 27% Median time to PCR- 71% Median time to PCR- (b) 64% c19hcq.org Chen et al. HCQ for COVID-19 RCT LATE TREATMENT Favors HCQ Favors control
Efficacy and safety of chloroquine or hydroxychloroquine in moderate type of COVID-19: a prospective open-label randomized controlled study
Chen et al., medRxiv, doi:10.1101/2020.06.19.20136093 (Preprint)
22 Jun 2020    Source   PDF   Share   Tweet
RCT 48 hospitalized patients in China showing faster clinical recovery and viral clearance with CQ/HCQ.
time to clinical recovery, 20.0% lower, relative time 0.80, p = 0.51, treatment median 6.0 IQR 5.0 n=18, control median 7.5 IQR 11.25 n=12, HCQ.
time to clinical recovery, 26.7% lower, relative time 0.73, p = 0.36, treatment median 5.5 IQR 4.25 n=18, control median 7.5 IQR 11.25 n=12, CQ.
median time to PCR-, 71.4% lower, relative time 0.29, p < 0.001, treatment median 2.0 IQR 1.5 n=18, control median 7.0 IQR 7.0 n=12, HCQ.
median time to PCR-, 64.3% lower, relative time 0.36, p = 0.001, treatment median 2.5 IQR 1.8 n=18, control median 7.0 IQR 7.0 n=12, CQ.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Chen et al., 22 Jun 2020, Randomized Controlled Trial, China, preprint, 19 authors, dosage 200mg bid days 1-10.
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This PaperHCQAll
Late treatment
is less effective
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