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Predictive Factors of Death and the Clinical Profile of Hospitalized Covid-19 Patients in Morocco: A One-Year Mixed Cohort Study

Charif et al., Cureus, doi:10.7759/cureus.32462
Dec 2022  
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Mortality, HCQ 27% Improvement Relative Risk HCQ for COVID-19  Charif et al.  LATE TREATMENT Is late treatment with HCQ beneficial for COVID-19? Retrospective 615 patients in Morocco (August 2020 - September 2021) Lower mortality with HCQ (p=0.00054) c19hcq.org Charif et al., Cureus, December 2022 FavorsHCQ Favorscontrol 0 0.5 1 1.5 2+
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now with p < 0.00000000001 from 417 studies, recognized in 46 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,800+ studies for 102 treatments. c19hcq.org
Retrospective 615 hospitalized COVID-19 patients in Morocco, showing lower mortality with HCQ in unadjusted results.
This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details.
risk of death, 27.2% lower, RR 0.73, p < 0.001, treatment 138 of 358 (38.5%), control 136 of 257 (52.9%), NNT 7.0, HCQ vs. no HCQ.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Charif et al., 13 Dec 2022, retrospective, Morocco, peer-reviewed, mean age 62.5, 10 authors, study period August 2020 - September 2021. Contact: faiza.charif@gmail.com.
This PaperHCQAll
Predictive Factors of Death and the Clinical Profile of Hospitalized Covid-19 Patients in Morocco: A One-Year Mixed Cohort Study
Faïza Charif, Zaynab Mahdi, Fadila Bousgheiri, Hassana Belafki, Adil Gourinda, Karima Sammoud, Fadila Salmane, Wiam Ftouh, Mariem Benkacem, Adil Najdi
Cureus, doi:10.7759/cureus.32462
Background Since the onset of the Covid-19 pandemic, several studies have been conducted around the world in an attempt to understand this heterogeneous and unpredictable disease and to prevent related death. It was therefore necessary to study the associated risk factors of Covid-19-related mortality. Objectives The aim of this study was to describe the clinical profile and to identify the factors associated with mortality of patients with Covid-19 in Morocco. Methods We performed a mixed cohort study (retrospective and prospective) of 615 in-patients with Covid-19 disease, enrolled between August 2020 and October 2021. We followed the cohort throughout the hospitalization until discharge and 30 days thereafter. Results The median age was 64 years old; 62.1% of the patients were male. The mean time from symptom onset to hospitalization was 8.5 days (±4.67), and 68.1% of patients had comorbidities. On admission, the most common symptoms were dyspnea (82.2%), cough (80.3%), and fever (76.8%). The main follow-up complication was secondary infection (56.9%). Based on univariate analysis, male gender (p<0.008 and brut relative risk { b RR}=1.57), advanced age (p<0.001), lung involvement (p<0.001), lymphopenia (p<0.001 and b RR=2.32), D-dimers of >500 µg/l (p<0.007 and b RR=2.47), C-reactive protein (CRP) of >130 mg/l (p<0.001 and b RR=2.45), elevated creatinine (p<0.013 and b RR=1.61), lactate dehydrogenase (LDH) of >500 U/l (p<0.001 and b RR=7.16), receiving corticosteroids (p<0.001 and b RR=5.08), invasive ventilation (p<0.001 and b RR=30.10), the stay in the resuscitation unit (p<0.001 and b RR=13.37), and acute respiratory distress syndrome (ARDS) (p<0.001 and b RR=10.98) were associated with a higher risk of death. In the opposite, receiving azithromycin and hydroxychloroquine (p<0.001 and b RR=0.28) and pre-admission anticoagulants (p<0.005 and b RR=0.46) was associated with a lower risk of mortality. Multivariate regression analysis showed that age of >60 years (p<0.001 and adjusted odds ratio {aOR}=4.90), the use of invasive ventilation (p<0.001 and aOR=9.60), the stay in the resuscitation unit (p<0.001 and aOR=5.09), and acute respiratory distress syndrome (p<0.001 and aOR=6.49) were independent predictors of Covid-19 mortality. Conclusion In this cohort study focusing on Covid-19 in-patient's mortality, we found that age of >60 years, the use of invasive ventilation, the stay in the resuscitation unit, and acute respiratory distress syndrome were independent predictors of Covid-19 mortality. The results of this study can be used to improve knowledge for better clinical management of Covid-19 in-patients.
Conclusions In this cohort study that focused on Covid-19 in-patient's mortality, we found that age of >60 years, the use of invasive ventilation, the stay in the resuscitation unit, and acute respiratory distress syndrome were independent predictors of Covid-19 mortality. These outcomes can be used to improve the clinical management of patients. Additional Information Disclosures Human subjects: Consent was obtained or waived by all participants in this study. Fes University Hospital Ethics Committee issued approval 03/21. By the unanimous vote of the members present, the committee adopted the following deliberation: favorable opinion. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.
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J Am ' 'Coll Cardiol. 2020, 76:1815-26. 10.1016/j.jacc.2020.08.041', 'journal-title': 'J Am Coll Cardiol'}], 'container-title': 'Cureus', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://www.cureus.com/articles/122896-predictive-factors-of-death-and-the-clinical-profile-of-hospitalized-covid-19-patients-in-morocco-a-one-year-mixed-cohort-study', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2022, 12, 13]], 'date-time': '2022-12-13T08:22:09Z', 'timestamp': 1670919729000}, 'score': 1, 'resource': { 'primary': { 'URL': 'https://www.cureus.com/articles/122896-predictive-factors-of-death-and-the-clinical-profile-of-hospitalized-covid-19-patients-in-morocco-a-one-year-mixed-cohort-study'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2022, 12, 13]]}, 'references-count': 30, 'URL': 'http://dx.doi.org/10.7759/cureus.32462', 'relation': {}, 'ISSN': ['2168-8184'], 'subject': ['Aerospace Engineering'], 'published': {'date-parts': [[2022, 12, 13]]}}
Late treatment
is less effective
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