Clinical features associated with COVID-19 outcome in multiple myeloma: first results from the International Myeloma Society data set

DOI record: { "DOI": "10.1182/blood.2020008150", "ISSN": [ "0006-4971", "1528-0020" ], "URL": "http://dx.doi.org/10.1182/blood.2020008150", "abstract": "<jats:title>Abstract</jats:title>\n <jats:p>The primary cause of morbidity and mortality in patients with multiple myeloma (MM) is an infection. Therefore, there is great concern about susceptibility to the outcome of COVID-19–infected patients with MM. This retrospective study describes the baseline characteristics and outcome data of COVID-19 infection in 650 patients with plasma cell disorders, collected by the International Myeloma Society to understand the initial challenges faced by myeloma patients during the COVID-19 pandemic. Analyses were performed for hospitalized MM patients. Among hospitalized patients, the median age was 69 years, and nearly all patients (96%) had MM. Approximately 36% were recently diagnosed (2019-2020), and 54% of patients were receiving first-line therapy. Thirty-three percent of patients have died, with significant geographic variability, ranging from 27% to 57% of hospitalized patients. Univariate analysis identified age, International Staging System stage 3 (ISS3), high-risk disease, renal disease, suboptimal myeloma control (active or progressive disease), and 1 or more comorbidities as risk factors for higher rates of death. Neither history of transplant, including within a year of COVID-19 diagnosis, nor other anti-MM treatments were associated with outcomes. Multivariate analysis found that only age, high-risk MM, renal disease, and suboptimal MM control remained independent predictors of adverse outcome with COVID-19 infection. The management of MM in the era of COVID-19 requires careful consideration of patient- and disease-related factors to decrease the risk of acquiring COVID-19 infection, while not compromising disease control through appropriate MM treatment. This study provides initial data to develop recommendations for the management of MM patients with COVID-19 infection.</jats:p>", "author": [ { "affiliation": [ { "name": "Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY;" } ], "family": "Chari", "given": "Ajai", "sequence": "first" }, { "affiliation": [ { "name": "Dana-Farber Cancer Institute, Boston, MA;" }, { "name": "Department of Data Science, Harvard T. H. Chan School of Public Health, Boston, MA;" } ], "family": "Samur", "given": "Mehmet Kemal", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0001-7908-0063", "affiliation": [ { "name": "Instituto de Investigación, Hospital Universitario 12 de Octubre (i+12), Madrid, Spain;" }, { "name": "Centro Nacional de Investigaciones Oncológicas (CNIO), Complutense University, Madrid, Spain;" } ], "authenticated-orcid": false, "family": "Martinez-Lopez", "given": "Joaquin", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0003-1717-0412", "affiliation": [ { "name": "Leeds Institute of Clinical Trial Research and" }, { "name": "Leeds Cancer Centre, University of Leeds, Leeds, United Kingdom;" } ], "authenticated-orcid": false, "family": "Cook", "given": "Gordon", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0003-0693-4202", "affiliation": [ { "name": "John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, NJ;" } ], "authenticated-orcid": false, "family": "Biran", "given": "Noa", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0002-6487-276X", "affiliation": [ { "name": "Department of Haematology, University College London Hospitals National Health Service (NHS) Foundation Trust, London, United Kingdom;" } ], "authenticated-orcid": false, "family": "Yong", "given": "Kwee", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0002-4327-1957", "affiliation": [ { "name": "Clínica São Germano, São Paulo, Brazil;" } ], "authenticated-orcid": false, "family": "Hungria", "given": "Vania", "sequence": "additional" }, { "affiliation": [ { "name": "Medical Department," }, { "name": "Hematology, Oncology and Stem Cell Transplantation, and" }, { "name": "Clinical Cancer Research Group, Faculty of Medicine, University of Freiburg, Freiburg, Germany;" } ], "family": "Engelhardt", "given": "Monika", "sequence": "additional" }, { "affiliation": [ { "name": "Myeloma Unit, Division of Hematology, University of Turin/Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Turin, Italy;" } ], "family": "Gay", "given": "Francesca", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Hematology, Hospital de Manises, Valencia, Spain;" } ], "family": "García Feria", "given": "Ana", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0002-3084-180X", "affiliation": [ { "name": "Hematology Laboratory, University of Turin, Turin, Italy;" } ], "authenticated-orcid": false, "family": "Oliva", "given": "Stefania", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0003-3650-4588", "affiliation": [ { "name": "Department of Haematology, University Medical Centre, Utrecht, The Netherlands;" } ], "authenticated-orcid": false, "family": "Oostvogels", "given": "Rimke", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Hematology, University of Siena, Siena, Italy;" } ], "family": "Gozzetti", "given": "Alessandro", "sequence": "additional" }, { "affiliation": [ { "name": "Center for Myeloma, New York Presbyterian Hospital-Weill Cornell Medical Center, New York, NY;" } ], "family": "Rosenbaum", "given": "Cara", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0001-5392-9284", "affiliation": [ { "name": "Division of Hematology, Mayo Clinic, Rochester, MN;" } ], "authenticated-orcid": false, "family": "Kumar", "given": "Shaji", "sequence": "additional" }, { "affiliation": [ { "name": "Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA;" } ], "family": "Stadtmauer", "given": "Edward A.", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Internal Medicine II, University Hospital of Würzburg, Würzburg, Germany;" } ], "family": "Einsele", "given": "Hermann", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0003-1797-8657", "affiliation": [ { "name": "Department of Hematology, Ankara University, Ankara, Turkey;" } ], 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