Cangiano et al. HCQ for COVID-19 LATE TREATMENT
Mortality in an Italian nursing home during COVID-19 pandemic: correlation with gender, age, ADL, vitamin D supplementation, and limitations of the diagnostic tests
et al., Aging,
Mortality in an Italian nursing home during COVID-19 pandemic: correlation with gender, age, ADL, vitamin D..
73% lower mortality with HCQ. Analysis of 98 PCR+ nursing home residents in Italy, mean age 90, showing HCQ mortality RR 0.27,
p = 0.03. Subject to confounding by contraindication. The paper provides the p value for regression but not the effect size.
risk of death, , treatment 5 of 33 (15.2%), control 37 of 65 (56.9%), NNT 2.4.
73.4% lower, RR 0.27, p = 0.03
Effect extraction follows
pre-specified rules prioritizing more serious outcomes. Submit updates
Cangiano et al., 22 Dec 2020, retrospective, Italy, peer-reviewed, 14 authors.
AGING 2020, Vol. 12, No. 24
Mortality in an Italian nursing home during COVID-19 pandemic:
correlation with gender, age, ADL, vitamin D supplementation, and
limitations of the diagnostic tests
Biagio Cangiano1,2,3,*, Letizia Maria Fatti1,*, Leila Danesi1, Giacomo Gazzano4, Marina Croci1,
Giovanni Vitale1,3,5, Luisa Gilardini1, Stefania Bonadonna1, Iacopo Chiodini1,2, Chiara Francesca
Caparello6, Antonio Conti1, Luca Persani1,2,3, Marco Stramba-Badiale7, Marco Bonomi1,2,3 on
behalf of the “Mons G. Bicchierai” nursing home group#
IRCCS Istituto Auxologico Italiano, Department of Endocrine and Metabolic Diseases, Milan, Italy
IRCCS Istituto Auxologico Italiano, Laboratory of Endocrine and Metabolic Diseases, Cusano Milanino, Italy
Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
IRCCS Istituto Auxologico Italiano, Anatomic Pathology Unit, Milan, Italy
IRCCS Istituto Auxologico Italiano, Laboratory of Geriatric and Oncologic Neuroendocrinology Research, Milan,
IRCCS Istituto Auxologico Italiano, Gastroenterology and Digestive Endoscopy, Milan, Italy
IRCCS Istituto Auxologico Italiano, Department of Geriatrics and Cardiovascular Medicine, Milan, Italy
“Mons. G. Bicchierai” nursing home group: Albergati S, Anselmi G, Calloni A, Bedogni S, Cammarata G, De Iulio C,
Di Stefano M, Federici S, Giancola N, Giovanelli L, Goggi G, Melzi L, Moro M, Nadiani B, Rindone A, Vannucchi G
Correspondence to: Marco Bonomi; email: firstname.lastname@example.org, email@example.com
Keywords: hydroxychloroquine, serology, nasopharyngeal swab, sensitivity and specificity, activities of daily living, COVID-19
Received: October 14, 2020
Accepted: November 16, 2020
Published: December 22, 2020
Copyright: © 2020 Cangiano et al. This is an open access article distributed under the terms of the Creative Commons
Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the
original author and source are credited.
Introduction: The COVID-19 pandemic caused an increased mortality in nursing homes due to its quick spread
and the age-related high lethality.
Results: We observed a two-month mortality of 40%, compared to 6.4% in the previous year. This increase was
seen in both COVID-19 positive (43%) and negative (24%) residents, but 8 patients among those testing
negative on the swab, tested positive on serological tests. Increased mortality was associated with male
gender, older age, no previous vitamin D supplementation and worse “activities of daily living (ADL)” scores,
such as Barthel index, Tinetti scale and S.OS.I.A. classification.
Conclusion: Our data confirms a higher geriatric mortality due to COVID-19. Negative residents also had higher
mortality, which we suspect is secondary to preanalytical error and a low sensitivity of the swab test in poorly
compliant subjects. Male gender, older age and low scores on ADL scales (probably due to immobility) are risk
factors for COVID-19 related mortality. Finally, mortality was inversely associated with vitamin D
Design: In this observational study, we described the two-month mortality among the 157 residents (age 60100) of a nursing home after Sars-CoV-2 spreading, reporting the factors associated with the outcome. We also
compared the diagnostic tests for..
is less effective
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