Treatment with hydroxychloroquine vs nitazoxanide in patients with COVID-19: brief report
et al., PAMJ - Clinical Medicine, doi:10.11604/pamj-cm.2021.7.15.30981
, Treatment with hydroxychloroquine vs nitazoxanide in patients with COVID-19: brief report, PAMJ - Clinical Medicine, doi:10.11604/pamj-cm.2021.7.15.30981
Planned RCT of HCQ vs. HCQ+nitazoxanide which was aborted due to the retracted Surgisphere paper. Authors retrospectively analyze a small set of HCQ vs. nitazoxanide patients (which were protocol deviations in the planned RCT), showing reduced hospitalization time and ICU admission with nitazoxanide.
|
risk of death, 214.8% higher, RR 3.15, p = 0.38, treatment 5 of 27 (18.5%), control 1 of 17 (5.9%).
|
|
risk of mechanical ventilation, 651.9% higher, RR 7.52, p = 0.15, treatment 4 of 27 (14.8%), control 0 of 17 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm).
|
|
risk of ICU admission, 145.5% higher, RR 2.45, p < 0.001, treatment 16 of 27 (59.3%), control 0 of 17 (0.0%), adjusted per study, inverted to make RR<1 favor treatment.
|
|
hospitalization time, 107.4% higher, relative time 2.07, p = 0.006, treatment 27, control 17.
|
| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Calderón et al., 23 Nov 2021, retrospective, Mexico, peer-reviewed, 7 authors, dosage 200mg bid days 1-7.
Late treatment
is less effective
is less effective
calderon2
Please send us corrections, updates, or comments. Vaccines and
treatments are complementary. All practical, effective, and safe means should
be used based on risk/benefit analysis. No treatment, vaccine, or intervention
is 100% available and effective for all current and future variants. We do not
provide medical advice. Before taking any medication, consult a qualified
physician who can provide personalized advice and details of risks and
benefits based on your medical history and situation. FLCCC and WCH
provide treatment protocols.