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All Studies   Meta Analysis   Recent:  
0 0.5 1 1.5 2+ Mortality -215% Improvement Relative Risk Ventilation -652% ICU admission -145% Hospitalization time -107% HCQ for COVID-19  Calderón et al.  LATE TREATMENT Is late treatment with HCQ beneficial for COVID-19? Retrospective 44 patients in Mexico Higher ICU admission (p<0.0001) and longer hospitalization (p=0.0065) c19hcq.org Calderón et al., PAMJ - Clinical Medic.., Nov 2021 Favors HCQ Favors control

Treatment with hydroxychloroquine vs nitazoxanide in patients with COVID-19: brief report

Calderón et al., PAMJ - Clinical Medicine, doi:10.11604/pamj-cm.2021.7.15.30981
Nov 2021  
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Planned RCT of HCQ vs. HCQ+nitazoxanide which was aborted due to the retracted Surgisphere paper. Authors retrospectively analyze a small set of HCQ vs. nitazoxanide patients (which were protocol deviations in the planned RCT), showing reduced hospitalization time and ICU admission with nitazoxanide.
This study includes HCQ and nitazoxanide.
risk of death, 214.8% higher, RR 3.15, p = 0.38, treatment 5 of 27 (18.5%), control 1 of 17 (5.9%).
risk of mechanical ventilation, 651.9% higher, RR 7.52, p = 0.15, treatment 4 of 27 (14.8%), control 0 of 17 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm).
risk of ICU admission, 145.5% higher, RR 2.45, p < 0.001, treatment 16 of 27 (59.3%), control 0 of 17 (0.0%), adjusted per study, inverted to make RR<1 favor treatment.
hospitalization time, 107.4% higher, relative time 2.07, p = 0.006, treatment 27, control 17.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Calderón et al., 23 Nov 2021, retrospective, Mexico, peer-reviewed, 7 authors, dosage 200mg bid days 1-7.
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Late treatment
is less effective
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