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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality -215% Improvement Relative Risk Ventilation -652% ICU admission -145% Hospitalization time -107% HCQ for COVID-19  Calderón et al.  LATE TREATMENT Is late treatment with HCQ beneficial for COVID-19? Retrospective 44 patients in Mexico Higher ICU admission (p<0.0001) and longer hospitalization (p=0.0065) c19hcq.org Calderón et al., PAMJ - Clinical Medic.., Nov 2021 Favors HCQ Favors control

Treatment with hydroxychloroquine vs nitazoxanide in patients with COVID-19: brief report

Calderón et al., PAMJ - Clinical Medicine, doi:10.11604/pamj-cm.2021.7.15.30981
Nov 2021  
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HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now known with p < 0.00000000001 from 421 studies, recognized in 42 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments. c19hcq.org
Planned RCT of HCQ vs. HCQ+nitazoxanide which was aborted due to the retracted Surgisphere paper. Authors retrospectively analyze a small set of HCQ vs. nitazoxanide patients (which were protocol deviations in the planned RCT), showing reduced hospitalization time and ICU admission with nitazoxanide.
Study covers HCQ and nitazoxanide.
risk of death, 214.8% higher, RR 3.15, p = 0.38, treatment 5 of 27 (18.5%), control 1 of 17 (5.9%).
risk of mechanical ventilation, 651.9% higher, RR 7.52, p = 0.15, treatment 4 of 27 (14.8%), control 0 of 17 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm).
risk of ICU admission, 145.5% higher, RR 2.45, p < 0.001, treatment 16 of 27 (59.3%), control 0 of 17 (0.0%), adjusted per study, inverted to make RR<1 favor treatment.
hospitalization time, 107.4% higher, relative time 2.07, p = 0.006, treatment 27, control 17.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Calderón et al., 23 Nov 2021, retrospective, Mexico, peer-reviewed, 7 authors, dosage 200mg bid days 1-7.
This PaperHCQAll
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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