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0 0.5 1 1.5 2+ Mortality -1% Improvement Relative Risk HCQ for COVID-19  Burhan et al.  ICU PATIENTS Is very late treatment with HCQ beneficial for COVID-19? Retrospective 559 patients in Indonesia (January 2020 - March 2021) No significant difference in mortality Burhan et al., PLOS ONE, September 2023 Favors HCQ Favors control

Characteristics and outcomes of patients with severe COVID-19 in Indonesia: Lessons from the first wave

Burhan et al., PLOS ONE, doi:10.1371/journal.pone.0290964
Sep 2023  
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Retrospective 559 COVID-19 ICU patients in Indonesia, showing no difference in mortality with HCQ in unadjusted results.
This study includes HCQ and remdesivir.
risk of death, 1.3% higher, RR 1.01, p = 0.91, treatment 84 of 123 (68.3%), control 294 of 436 (67.4%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Burhan et al., 25 Sep 2023, retrospective, Indonesia, peer-reviewed, 26 authors, study period January 2020 - March 2021.
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Characteristics and outcomes of patients with severe COVID-19 in Indonesia: Lessons from the first wave
Erlina Burhan, Keibun Liu, Eva M Marwali, Samuel Huth, Navy G H M L Wulung, Dafsah A Juzar, Muhammad A Taufik, Surya O Wijaya, Dyah K Wati, Neurinda P Kusumastuti, Saptadi Yuliarto, Bhirowo Y Pratomo, Erwin Pradian, Dadang H Somasetia, Desy Rusmawatiningtyas, Arie Z Fatoni, Jose M Mandei, Eka Y Lantang, Fajar Perdhana, Bambang P Semedi, Muhammad Rayhan, Tiffany R S Tarigan, Nicole White, Gianluigi L Bassi, Jacky Y Suen, John F Fraser
PLOS ONE, doi:10.1371/journal.pone.0290964
Background Indonesia's national response to COVID-19 evolved rapidly throughout 2020. Understanding pandemic response and outcomes is crucial for better mitigation strategies ahead. This study describes the characteristics and outcomes of patients admitted to ICU during the early stages of the pandemic. Methods This is a multi-centre prospective observational study including patients from twelve collaborating hospitals in Indonesia. All patients were clinically suspected or laboratory-confirmed COVID-19 cases admitted to ICU between January 2020 and March 2021. The primary outcome was monthly ICU mortality. Descriptive statistics of patient characteristics and treatment were generated as secondary outcomes.
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Late treatment
is less effective
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