Analgesics
Antiandrogens
Antihistamines
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
PPIs
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
 
next
study
previous
study
c19hcq.org COVID-19 treatment researchHCQHCQ (more..)
Melatonin Meta
Metformin Meta
Antihistamines Meta
Azvudine Meta Molnupiravir Meta
Bromhexine Meta
Budesonide Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta PPIs Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis       

Clinical characteristics and factors associated with ICU mortality during the first year of the SARS-Cov-2 pandemic in Romania

Bubenek-Turconi et al., European Journal of Anaesthesiology, doi:10.1097/EJA.0000000000001776
Nov 2022  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Mortality 22% Improvement Relative Risk HCQ for COVID-19  Bubenek-Turconi et al.  ICU PATIENTS Is very late treatment with HCQ beneficial for COVID-19? Prospective study in Romania (March 2020 - March 2021) Lower mortality with HCQ (p=0.014) c19hcq.org Bubenek-Turconi et al., European J. An.., Nov 2022 FavorsHCQ Favorscontrol 0 0.5 1 1.5 2+
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020, now with p < 0.00000000001 from 419 studies, recognized in 46 countries.
No treatment is 100% effective. Protocols combine treatments.
5,100+ studies for 112 treatments. c19hcq.org
Prospective study of 9,058 COVID-19 ICU patients in Romania, showing lower mortality with HCQ treatment.
risk of death, 22.0% lower, OR 0.78, p = 0.01, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Bubenek-Turconi et al., 17 Nov 2022, prospective, Romania, peer-reviewed, 16 authors, study period March 2020 - March 2021.
This PaperHCQAll
{ 'indexed': { 'date-parts': [[2022, 11, 18]], 'date-time': '2022-11-18T05:58:13Z', 'timestamp': 1668751093160}, 'reference-count': 34, 'publisher': 'Ovid Technologies (Wolters Kluwer Health)', 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'DOI': '10.1097/eja.0000000000001776', 'type': 'journal-article', 'created': { 'date-parts': [[2022, 11, 17]], 'date-time': '2022-11-17T11:00:11Z', 'timestamp': 1668682811000}, 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Clinical characteristics and factors associated with ICU mortality during the first year of the ' 'SARS-Cov-2 pandemic in Romania', 'prefix': '10.1097', 'volume': 'Publish Ahead of Print', 'author': [ {'given': 'Şerban-Ion', 'family': 'Bubenek-Turconi', 'sequence': 'first', 'affiliation': []}, {'given': 'Stefan', 'family': 'Andrei', 'sequence': 'additional', 'affiliation': []}, {'given': 'Liana', 'family': 'Văleanu', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mihai-Gabriel', 'family': 'Ştefan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ioana', 'family': 'Grigoraş', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sanda', 'family': 'Copotoiu', 'sequence': 'additional', 'affiliation': []}, {'given': 'Constantin', 'family': 'Bodolea', 'sequence': 'additional', 'affiliation': []}, {'given': 'Dana', 'family': 'Tomescu', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mihai', 'family': 'Popescu', 'sequence': 'additional', 'affiliation': []}, {'given': 'Daniela', 'family': 'Filipescu', 'sequence': 'additional', 'affiliation': []}, {'given': 'Horațiu', 'family': 'Moldovan', 'sequence': 'additional', 'affiliation': []}, { 'given': 'Alexandru-Florin', 'family': 'Rogobete', 'sequence': 'additional', 'affiliation': []}, {'given': 'Cosmin', 'family': 'Bălan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Bianca', 'family': 'Moroşanu', 'sequence': 'additional', 'affiliation': []}, {'given': 'Dorel', 'family': 'Săndesc', 'sequence': 'additional', 'affiliation': []}, {'given': 'Raed', 'family': 'Arafat', 'sequence': 'additional', 'affiliation': []}], 'member': '276', 'published-online': {'date-parts': [[2022, 11, 17]]}, 'reference': [ { 'key': 'R1-20221117', 'doi-asserted-by': 'crossref', 'first-page': '1268', 'DOI': '10.1056/NEJMe2002387', 'article-title': 'Covid-19 — navigating the uncharted', 'volume': '382', 'author': 'Fauci', 'year': '2020', 'journal-title': 'N Engl J Med'}, { 'key': 'R2-20221117', 'doi-asserted-by': 'crossref', 'first-page': '138882', 'DOI': '10.1016/j.scitotenv.2020.138882', 'article-title': 'COVID-19 outbreak: migration, effects on society, global environment ' 'and prevention', 'volume': '728', 'author': 'Chakraborty', 'year': '2020', 'journal-title': 'Sci Total Environ'}, { 'key': 'R3-20221117', 'doi-asserted-by': 'crossref', 'first-page': '1315', 'DOI': '10.1016/S0140-6736(20)30938-7', 'article-title': 'The Lancet. India under COVID-19 lockdown', 'volume': '395', 'year': '2020', 'journal-title': 'The Lancet'}, { 'key': 'R4-20221117', 'doi-asserted-by': 'crossref', 'first-page': '60', 'DOI': '10.1007/s00134-020-06294-x', 'article-title': 'Clinical characteristics and day-90 outcomes of 4244 critically ill ' 'adults with COVID-19: a prospective cohort study', 'volume': '47', 'year': '2021', 'journal-title': 'Intensive Care Med'}, { 'key': 'R5-20221117', 'doi-asserted-by': 'crossref', 'first-page': '266', 'DOI': '10.1016/j.ijid.2020.08.001', 'article-title': 'Clinical characteristics of asymptomatic patients with COVID-19: a ' 'nationwide cohort study in South Korea', 'volume': '99', 'author': 'Jung', 'year': '2020', 'journal-title': 'Int J Infect Dis'}, { 'key': 'R6-20221117', 'doi-asserted-by': 'crossref', 'first-page': 'e2029058', 'DOI': '10.1001/jamanetworkopen.2020.29058', 'article-title': 'Risk factors associated with in-hospital mortality in a US national ' 'sample of patients with COVID-19', 'volume': '3', 'author': 'Rosenthal', 'year': '2020', 'journal-title': 'JAMA Netw Open'}, { 'key': 'R7-20221117', 'doi-asserted-by': 'crossref', 'first-page': 'e042712', 'DOI': '10.1136/bmjopen-2020-042712', 'article-title': 'Retrospective cohort study of admission timing and mortality following ' 'COVID-19 infection in England', 'volume': '10', 'author': 'Alaa', 'year': '2020', 'journal-title': 'BMJ Open'}, { 'key': 'R8-20221117', 'doi-asserted-by': 'crossref', 'first-page': '335', 'DOI': '10.1097/EJA.0000000000001459', 'article-title': 'National outcomes and characteristics of patients admitted to Swedish ' 'intensive care units for COVID-19: a registry-based cohort study', 'volume': '38', 'author': 'Chew', 'year': '2021', 'journal-title': 'Eur J Anaesthesiol'}, { 'key': 'R9-20221117', 'doi-asserted-by': 'crossref', 'first-page': '1710', 'DOI': '10.1016/j.jfma.2020.05.029', 'article-title': 'Mortality from COVID-19: a cross-country comparison of containment ' 'versus mitigation strategy', 'volume': '119', 'author': 'Chen', 'year': '2020', 'journal-title': 'J Formosan Med Assoc'}, { 'key': 'R10-20221117', 'doi-asserted-by': 'crossref', 'first-page': '2459', 'DOI': '10.1111/apa.15582', 'article-title': "The first eight months of Sweden's COVID-19 strategy and the key " 'actions and actors that were involved', 'volume': '109', 'author': 'Ludvigsson', 'year': '2020', 'journal-title': 'Acta Paediatr'}, { 'key': 'R11-20221117', 'doi-asserted-by': 'crossref', 'first-page': 'e006427', 'DOI': '10.1136/bmjgh-2021-006427', 'article-title': 'Unequal burden of COVID-19 in Hungary: a geographical and socioeconomic ' 'analysis of the second wave of the pandemic', 'volume': '6', 'author': 'Oroszi', 'year': '2021', 'journal-title': 'BMJ Glob Health'}, { 'key': 'R12-20221117', 'doi-asserted-by': 'crossref', 'first-page': '157', 'DOI': '10.1097/EJA.0000000000000382', 'article-title': 'Migration of skilled anaesthesiologists from low to high-income ' 'economies: urgent action needed', 'volume': '33', 'author': 'Mitre', 'year': '2016', 'journal-title': 'Eur J Anaesthesiol'}, { 'key': 'R13-20221117', 'doi-asserted-by': 'crossref', 'first-page': 'e932788', 'DOI': '10.12659/MSM.932788', 'article-title': 'Acceptance of COVID-19 vaccination and its associated factors among ' 'cancer patients attending the oncology clinic of university clinical ' 'hospital Mostar, Bosnia and Herzegovina: a cross-sectional study', 'volume': '27', 'author': 'Marijanović', 'year': '2021', 'journal-title': 'Med Sci Monit'}, { 'key': 'R14-20221117', 'doi-asserted-by': 'crossref', 'first-page': '1047', 'DOI': '10.32687/0869-866X-2021-29-5-1047-1056', 'article-title': 'The social demographic aspects of vaccination of population of Russia ' 'in the context of COVID-19 pandemic', 'volume': '29', 'author': 'Ryazantsev', 'year': '2021', 'journal-title': 'Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med'}, { 'key': 'R15-20221117', 'article-title': 'National strategies for vaccination against COVID-19 in people living ' 'with HIV in Central and Eastern European region', 'author': 'Jilich', 'year': '2021', 'journal-title': 'HIV Med'}, { 'key': 'R18-20221117', 'doi-asserted-by': 'crossref', 'first-page': '403', 'DOI': '10.1164/rccm.202012-4547OC', 'article-title': 'Hospital-level variation in death for critically ill patients with ' 'COVID-19', 'volume': '204', 'author': 'Churpek', 'year': '2021', 'journal-title': 'Am J Respir Crit Care Med'}, { 'key': 'R19-20221117', 'doi-asserted-by': 'crossref', 'first-page': '1345', 'DOI': '10.1001/jamainternmed.2020.3539', 'article-title': 'Risk factors associated with mortality among patients with COVID-19 in ' 'intensive care units in Lombardy, Italy', 'volume': '180', 'author': 'Grasselli', 'year': '2020', 'journal-title': 'JAMA Intern Med'}, { 'key': 'R20-20221117', 'doi-asserted-by': 'crossref', 'first-page': '6648199', 'DOI': '10.1155/2021/6648199', 'article-title': 'Predictors of mortality in critically Ill COVID-19 patients demanding ' 'high oxygen flow: a thin line between inflammation, cytokine storm, and ' 'coagulopathy', 'volume': '2021', 'author': 'Popadic', 'year': '2021', 'journal-title': 'Oxid Med Cell Longev'}, { 'key': 'R21-20221117', 'doi-asserted-by': 'crossref', 'first-page': '1224', 'DOI': '10.1111/anae.15532', 'article-title': 'Factors associated with mortality in patients with COVID-19 admitted to ' 'intensive care: a systematic review and meta-analysis', 'volume': '76', 'author': 'Taylor', 'year': '2021', 'journal-title': 'Anaesthesia'}, { 'key': 'R22-20221117', 'doi-asserted-by': 'crossref', 'first-page': 'e0241955', 'DOI': '10.1371/journal.pone.0241955', 'article-title': 'Prognostic factors for severity and mortality in patients infected with ' 'COVID-19: a systematic review', 'volume': '15', 'author': 'Izcovich', 'year': '2020', 'journal-title': 'PLoS One'}, { 'key': 'R23-20221117', 'doi-asserted-by': 'crossref', 'first-page': 'e28', 'DOI': '10.1093/gerona/glaa243', 'article-title': 'Clinical characteristics and risk factors for mortality in very old ' 'patients hospitalized with COVID-19 in Spain', 'volume': '76', 'author': 'Ramos-Rincon', 'year': '2021', 'journal-title': 'J Gerontol'}, { 'key': 'R24-20221117', 'doi-asserted-by': 'crossref', 'first-page': '82', 'DOI': '10.1016/j.ajic.2020.06.008', 'article-title': 'Meta-analysis investigating the relationship between clinical features, ' 'outcomes, and severity of severe acute respiratory syndrome coronavirus ' '2 (SARS-CoV-2) pneumonia', 'volume': '49', 'author': 'Li', 'year': '2021', 'journal-title': 'Am J Infect Control'}, { 'key': 'R25-20221117', 'doi-asserted-by': 'crossref', 'first-page': '1544', 'DOI': '10.3390/jcm11061544', 'article-title': 'Outcomes of COVID-19 critically ill extremely elderly patients: ' 'analysis of a large, national, observational cohort', 'volume': '11', 'author': 'Andrei', 'year': '2022', 'journal-title': 'JCM'}, { 'key': 'R26-20221117', 'doi-asserted-by': 'crossref', 'first-page': '2052', 'DOI': '10.1001/jama.2020.6775', 'article-title': 'Presenting characteristics, comorbidities, and outcomes among 5700 ' 'patients hospitalized with COVID-19 in the New York city area', 'volume': '323', 'author': 'Richardson', 'year': '2020', 'journal-title': 'JAMA'}, { 'key': 'R27-20221117', 'doi-asserted-by': 'crossref', 'first-page': 'e0246318', 'DOI': '10.1371/journal.pone.0246318', 'article-title': 'COVID-19 ICU and mechanical ventilation patient characteristics and ' 'outcomes—a systematic review and meta-analysis', 'volume': '16', 'author': 'Chang', 'year': '2021', 'journal-title': 'PLoS One'}, { 'key': 'R28-20221117', 'doi-asserted-by': 'crossref', 'first-page': '1076', 'DOI': '10.1016/j.cmi.2021.04.019', 'article-title': 'Efficacy and safety of tocilizumab in COVID-19 patients: a living ' 'systematic review and meta-analysis, first update', 'volume': '27', 'author': 'Tleyjeh', 'year': '2021', 'journal-title': 'Clin Microbiol Infect'}, { 'key': 'R29-20221117', 'doi-asserted-by': 'crossref', 'first-page': 'n1038', 'DOI': '10.1136/bmj.n1038', 'article-title': 'Use of repurposed and adjuvant drugs in hospital patients with ' 'covid-19: multinational network cohort study', 'author': 'Prats-Uribe', 'year': '2021', 'journal-title': 'BMJ'}, { 'key': 'R30-20221117', 'doi-asserted-by': 'crossref', 'first-page': '100019', 'DOI': '10.1016/j.lanepe.2020.100019', 'article-title': 'The role of organizational characteristics on the outcome of COVID-19 ' 'patients admitted to the ICU in Belgium', 'volume': '2', 'author': 'Taccone', 'year': '2021', 'journal-title': 'Lancet Regional Health - Europe'}, { 'key': 'R31-20221117', 'doi-asserted-by': 'crossref', 'first-page': '1330', 'DOI': '10.1001/jama.2020.17023', 'article-title': 'Association between administration of systemic corticosteroids and ' 'mortality among critically ill patients with COVID-19: a meta-analysis', 'volume': '324', 'author': 'Sterne', 'year': '2020', 'journal-title': 'JAMA'}, { 'key': 'R32-20221117', 'doi-asserted-by': 'crossref', 'first-page': '1049', 'DOI': '10.1080/17476348.2021.1925546', 'article-title': 'Does methylprednisolone reduce the mortality risk in hospitalized ' 'COVID-19 patients? A meta-analysis of randomized control trials', 'volume': '15', 'author': 'Hasan', 'year': '2021', 'journal-title': 'Expert Rev Respir Med'}, { 'key': 'R33-20221117', 'doi-asserted-by': 'crossref', 'first-page': '1637', 'DOI': '10.1016/S0140-6736(21)00676-0', 'article-title': 'Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): ' 'a randomised, controlled, open-label, platform trial', 'volume': '397', 'author': 'Abbas', 'year': '2021', 'journal-title': 'Lancet'}, { 'key': 'R34-20221117', 'doi-asserted-by': 'crossref', 'first-page': '72', 'DOI': '10.1186/s13054-021-03493-w', 'article-title': 'Epidemiology and microbiology of ventilator-associated pneumonia in ' 'COVID-19 patients: a multicenter retrospective study in 188 patients in ' 'an un-inundated French region', 'volume': '25', 'author': 'Blonz', 'year': '2021', 'journal-title': 'Crit Care'}, { 'key': 'R35-20221117', 'first-page': 'w30105', 'article-title': 'Evolution of COVID-19 mortality over time: results from the Swiss ' 'hospital surveillance system (CH-SUR)', 'volume': '151', 'author': 'Roelens', 'year': '2021', 'journal-title': 'Swiss Med Wkly'}, { 'key': 'R36-20221117', 'doi-asserted-by': 'crossref', 'first-page': '1781', 'DOI': '10.3390/ijerph19031781', 'article-title': 'ICU-associated costs during the fourth wave of the COVID-19 pandemic in ' 'a tertiary hospital in a low-vaccinated Eastern European Country', 'volume': '19', 'author': 'Popescu', 'year': '2022', 'journal-title': 'IJERPH'}], 'container-title': 'European Journal of Anaesthesiology', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://journals.lww.com/10.1097/EJA.0000000000001776', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2022, 11, 17]], 'date-time': '2022-11-17T11:00:25Z', 'timestamp': 1668682825000}, 'score': 1, 'resource': {'primary': {'URL': 'https://journals.lww.com/10.1097/EJA.0000000000001776'}}, 'subtitle': ['A prospective, cohort, multicentre study of 9000 patients'], 'short-title': [], 'issued': {'date-parts': [[2022, 11, 17]]}, 'references-count': 34, 'URL': 'http://dx.doi.org/10.1097/EJA.0000000000001776', 'relation': {}, 'ISSN': ['0265-0215', '1365-2346'], 'subject': ['Anesthesiology and Pain Medicine'], 'published': {'date-parts': [[2022, 11, 17]]}}
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit