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0 0.5 1 1.5 2+ Viral clearance 15% Improvement Relative Risk HCQ for COVID-19  Brouqui et al.  EARLY TREATMENT Is early treatment with HCQ beneficial for COVID-19? Retrospective 1,276 patients in France (March 2020 - March 2021) Improved viral clearance with HCQ (p=0.037) Brouqui et al., Authorea, Inc., March 2023 Favors HCQ Favors control

Viral clearance in patients with COVID-19: associated factors and the role of antiviral treatment

Brouqui et al., Authorea, Inc., doi:10.22541/au.167948825.59270994/v1
Mar 2023  
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HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
*, now known with p < 0.00000000001 from 421 studies, recognized in 42 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments.
Retrospective 1,276 patients in France, showing faster viral clearance with HCQ treatment.
risk of no viral clearance, 15.3% lower, HR 0.85, p = 0.04, treatment 776, control 500, adjusted per study, inverted to make HR<1 favor treatment, multivariable, Cox proportional hazards.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Brouqui et al., 22 Mar 2023, retrospective, France, preprint, 8 authors, study period 3 March, 2020 - 13 March, 2021.
This PaperHCQAll
Viral clearance in patients with COVID-19: associated factors and the role of antiviral treatment
Philippe Brouqui, Jean-Christophe Lagier, P Parola, M Million, S Cortaredona, Léa Delorme, Philippe Colson, Didier Raoult
The role of hydroxychloroquine (HCQ) in lowering the viral load of patients with COVID-19 is controversial. In our Institute, we treated more than 30,000 people with COVID-19 in 2020 and 2021, using the same diagnostic tools and the same treatment dosages. In this retrospective comparative study of data collected over this period, we aimed to compare the viral clearance in the nasopharynx as determined by qPCR in patients who were treated with HCQ and those who were not. As a new feature, we adjusted the data according to the most significant confounding factors (age, initial viral load, and timescale between the onset of symptoms and treatment). Of the 1 276 patients selected from our database, 776 were treated with HCQ and 500 were not. Viral clearance in the treatment group was reached significantly earlier than in the non-treatment group, at days 5, 10 and 30. These differences remain significant after adjustments for confounding factors. In conclusion, although age, initial viral load, and time to treatment do influence the viral load in patients with COVID-19, hydroxychloroquine associated with azithromycin still independently significantly lowered viral load more rapidly than other treatments, including azithromycin alone.
Hosted file Table 1 .docx available at Hosted file Table 2 .docx available at Hosted file Table 3 .docx available at
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