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0 0.5 1 1.5 2+ Mortality 22% Improvement Relative Risk HCQ for COVID-19  Bielza et al.  LATE TREATMENT Is late treatment with HCQ beneficial for COVID-19? Retrospective 630 patients in Spain Lower mortality with HCQ (not stat. sig., p=0.088) Bielza et al., J. the American Medical.., Dec 2020 Favors HCQ Favors control

Clinical characteristics, frailty and mortality of residents with COVID-19 in nursing homes of a region of Madrid

Bielza et al., Journal of the American Medical Directors Association, doi:10.1016/j.jamda.2020.12.003
Dec 2020  
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HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
*, now known with p < 0.00000000001 from 421 studies, recognized in 42 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments.
Retrospective 630 elderly patients in Spain showing lower mortality with HCQ treatment, unadjusted relative risk RR 0.78, p = 0.09. HCQ was used more often with patients that were hospitalized (24% versus 3% use in the nursing homes). Median age 87.
Although the 22% lower mortality is not statistically significant, it is consistent with the significant 24% lower mortality [20‑29%] from meta analysis of the 249 mortality results to date.
This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details.
risk of death, 21.5% lower, RR 0.78, p = 0.09, treatment 33 of 91 (36.3%), control 249 of 539 (46.2%), NNT 10.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Bielza et al., 11 Dec 2020, retrospective, Spain, peer-reviewed, median age 87.0, 24 authors.
This PaperHCQAll
Clinical Characteristics, Frailty, and Mortality of Residents With COVID-19 in Nursing Homes of a Region of Madrid
MD Rafael Bielza, MD Juan Sanz, MD Francisco Zambrana, MD Estefanía Arias, MD Eduardo Malmierca, MD Laura Portillo, MD Israel J Thuissard, MD Ana Lung, MD Marta Neira, María Moral, PhD a, b , María Moral MD g Cristina Andreu-Vázquez, MD h Ana Esteban, MD i Marcela Irma Ramírez, MD j Laura González, MD k Guillermo Carretero, Ricardo Vicente Moreno, MD l Pilar Martínez, MD Javier López, Mar Esteban-Ortega, MD Isabel García, María Antonia Vaquero, MD Ana Linares, MD Ana Gómez-Santana, Jorge Gómez Cerezo
Journal of the American Medical Directors Association, doi:10.1016/j.jamda.2020.12.003
Objectives: To describe the clinical characteristics, 30-day mortality, and associated factors of patients living in nursing homes (NH) with COVID-19, from March 20 to June 1, 2020. Design: This is a retrospective study. A geriatric hospital-based team acted as a consultant and coordinated the care of older people living in NHs from the hospital. Setting and Participants: A total of 630 patients aged 70 and older with Coronavirus Disease 2019 COVID-19 living in 55 NHs. Methods: A logistic regression was performed to analyze the factors associated with mortality. In addition, Kaplan-Meier curves were applied according to mortality and its associated factors using the logrank Mantel-Cox test. Results: The diagnosis of COVID-19 was mainly made by clinical compatibility (N ¼ 430). Median age was 87 years, 64.6% were women and 45.9% were transferred to be cared for at the hospital. A total of 282 patients died (44.7%) within the 30 days of first attention by the team. A severe form of COVID-19 occurred in 473 patients, and the most frequent symptoms were dyspnea (n ¼ 332) and altered level of consciousness (n ¼ 301). According to multiple logistic regression, male sex (P ¼ .019), the Clinical
Abrams, Loomer, Gandhi, Grabowski, Characteristics of U.S. nursing homes with COVID-19 cases, J Am Geriatr Soc
Bernabeu-Wittel, Vega, Díaz-Jiménez, Death risk stratification in elderly patients with covid-19. A comparative cohort study in nursing homes outbreaks, Arch Gerontol Geriatr
Bonanad, García-Blas, Tarazona-Santabalbina, The effect of age on mortality in patients with COVID-19: A meta-analysis with 611,583 subjects, J Am Med Dir Assoc
Borobia, Carcas, Arnalich, A cohort of patients with COVID-19 in a major teaching hospital in Europe, J Clin Med
Chen, Zhou, Dong, Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study, Lancet
Cid-Ruzafa, Moreno, Valoración de la discapacidad física: el indice de Barthel, Rev Esp Salud Publica
Comas-Herrera, Zalakaín, Litwin, Mortality associated with COVID-19 outbreaks in care homes: early international evidence
Ellis, Wan, Yeung, Complementing chronic frailty assessment at hospital admission with an electronic frailty index (FI-Laboratory) comprising routine blood test results, CMAJ
Farrell, Francis, Brown, Rationing limited healthcare resources in the COVID-19 era and beyond: Ethical considerations regarding older adults, J Am Geriatr Soc
Gordon, Goodman, Achterberg, Commentary: COVID in care homes-challenges and dilemmas in healthcare delivery, Age Ageing
Guan, Ni, Hu, Clinical characteristics of coronavirus disease 2019 in China, N Engl J Med
Hewitt, Carter, Vilches-Moraga, The effect of frailty on survival in patients with COVID-19 (COPE): A multicentre, European, observational cohort study, Lancet Public Health
Huang, Wang, Li, Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China, Lancet
Lau-Ng, Caruso, Perls, COVID-19 deaths in long-term care facilities: A critical piece of the pandemic puzzle, J Am Geriatr Soc
Lithander, Neumann, Tenison, COVID-19 in older people: A rapid clinical review, Age Ageing
Liu, Chen, Lin, Han, Clinical features of COVID-19 in elderly patients: A comparison with young and middle-aged patients, J Infect
Liu, Fang, Deng, Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province, Chin Med J (Engl)
Martinez-Peromingo, Serra-Rexach, Long-term care facilities and the COVID-19 pandemic: Lessons learned in Madrid, J Am Geriatr Soc
Mitchell, Maynard, Lyons, The role and response of primary healthcare services in the delivery of palliative care in epidemics and pandemics: A rapid review to inform practice and service delivery during the COVID-19 pandemic, Palliat Med
Norman, Stall, Sinha, Typically atypical: COVID-19 presenting as a fall in an older adult, J Am Geriatr Soc
Poloni, Carlos, Cairati, Prevalence and prognostic value of delirium as the initial presentation of COVID-19 in the elderly with dementia: An Italian retrospective study, EClinicalMedicine
Reisberg, Ferris, Leon, Crook, The global deterioration scale for assessment of primary degenerative dementia, Am J Psychiatry
Renom-Guiteras, Uhrenfeldt, Meyer, Mann, Assessment tools for determining appropriateness of admission to acute care of persons transferred from long-term care facilities: A systematic review, BMC Geriatr
Richardson, Hirsch, Narasimhan, Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City Area, JAMA
Smet, Mellaerts, Vandewinckele, Frailty and mortality in hospitalized older adults with COVID-19: Retrospective observational study, J Am Med Dir Assoc
Sun, Ning, Tao, Risk factors for mortality in 244 older adults with COVID-19 in Wuhan, China: A retrospective study, J Am Geriatr Soc
Wang, He, Yu, Coronavirus disease 2019 in elderly patients: Characteristics and prognostic factors based on 4-week follow-up, J Infect
Wu, Mcgoogan, Characteristics of and important lessons from the Coronavirus Disease 2019 (COVID-19) outbreak in China: Summary of a report of 72314 cases from the Chinese Center for Disease Control and Prevention, JAMA
Zhao, Huang, Huang, Mortality in older patients with Covid-19, J Am Geriatr Soc
Late treatment
is less effective
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