Clinical characteristics, frailty and mortality of residents with COVID-19 in nursing homes of a region of Madrid
et al., Journal of the American Medical Directors Association, doi:10.1016/j.jamda.2020.12.003
, Clinical characteristics, frailty and mortality of residents with COVID-19 in nursing homes of a region of.., Journal of the American Medical Directors Association, doi:10.1016/j.jamda.2020.12.003
Retrospective 630 elderly patients in Spain showing lower mortality with HCQ treatment, unadjusted relative risk RR 0.78, p = 0.09. HCQ was used more often with patients that were hospitalized (24% versus 3% use in the nursing homes). Median age 87.Although the 22% lower mortality is not statistically significant, it is consistent with the significant 22% lower mortality [18‑27%] from meta analysis of the 232 mortality results to date.
This study is excluded in the after exclusion results of meta
analysis:
unadjusted results with no group details.
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risk of death, 21.5% lower, RR 0.78, p = 0.09, treatment 33 of 91 (36.3%), control 249 of 539 (46.2%), NNT 10.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Bielza et al., 11 Dec 2020, retrospective, Spain, peer-reviewed, median age 87.0, 24 authors.
Abstract: JAMDA 22 (2021) 245e252
JAMDA
journal homepage: www.jamda.com
Original Study
Clinical Characteristics, Frailty, and Mortality of Residents With
COVID-19 in Nursing Homes of a Region of Madrid
Rafael Bielza MD, PhD a, b, *, Juan Sanz MD c, Francisco Zambrana MD b, d,
Estefanía Arias MD a, b, Eduardo Malmierca MD, PhD b, e, Laura Portillo MD b, f,
Israel J. Thuissard MD, PhD b, Ana Lung MD a, b, Marta Neira MD, PhD a, b, María Moral MD g,
Cristina Andreu-Vázquez PhD b, Ana Esteban MD h, Marcela Irma Ramírez MD i,
Laura González MD j, Guillermo Carretero MD k, Ricardo Vicente Moreno MD l,
Pilar Martínez MD l, Javier López MD b, l, Mar Esteban-Ortega MD, PhD b, m,
Isabel García MD, PhD b, m, María Antonia Vaquero MD, PhD b, n, Ana Linares MD, PhD b, o,
Ana Gómez-Santana MD p, Jorge Gómez Cerezo MD, PhD b, e
a
Department of Geriatric Medicine, Hospital Universitario Infanta Sofía (San Sebastián de los Reyes), Madrid, Spain
Faculty of Biomedical and Health Sciences, Department of Medicine, Universidad Europea de Madrid, Madrid, Spain
Department of Dermatology, Hospital Universitario Infanta Sofía (San Sebastián de los Reyes), Madrid, Spain
d
Department of Oncology, Hospital Universitario Infanta Sofía (San Sebastián de los Reyes), Madrid, Spain
e
Department of Internal Medicine, Hospital Universitario Infanta Sofía (San Sebastián de los Reyes), Madrid, Spain
f
Department of Pharmacy, Hospital Universitario Infanta Sofía (San Sebastián de los Reyes), Madrid, Spain
g
Department of Palliative Care, Hospital Universitario Infanta Sofía (San Sebastián de los Reyes), Madrid, Spain
h
Department of Rheumatology, Hospital Universitario Infanta Sofía (San Sebastián de los Reyes), Madrid, Spain
i
Department of Endocrinology, Hospital Universitario Infanta Sofía (San Sebastián de los Reyes), Madrid, Spain
j
Department of Neurology, Hospital Universitario Infanta Sofía (San Sebastián de los Reyes), Madrid, Spain
k
Department of Orthopedics, Hospital Universitario Infanta Sofía (San Sebastián de los Reyes), Madrid, Spain
l
Department of Rehabilitation, Hospital Universitario Infanta Sofía (San Sebastián de los Reyes), Madrid, Spain
m
Department of Ophthalmology, Hospital Universitario Infanta Sofía (San Sebastián de los Reyes), Madrid, Spain
n
Department of General Surgery, Hospital Universitario Infanta Sofía (San Sebastián de los Reyes), Madrid, Spain
o
Department of Urology, Hospital Universitario Infanta Sofía (San Sebastián de los Reyes), Madrid, Spain
p
Department of Preventive Medicine, Hospital Universitario Infanta Sofía (San Sebastián de los Reyes), Madrid, Spain
b
c
a b s t r a c t
Keywords:
Nursing homes
mortality
geriatric hospital-based team
clinical frailty score
Objectives: To describe the clinical characteristics, 30-day mortality, and associated factors of patients
living in nursing homes (NH) with COVID-19, from March 20 to June 1, 2020.
Design: This is a retrospective study. A geriatric hospital-based team acted as a consultant and coordinated the care of older people living in NHs from the hospital.
Setting and Participants: A total of 630 patients aged 70 and older with Coronavirus Disease 2019 COVID19 living in 55 NHs.
Methods: A logistic regression was performed to analyze the factors associated with mortality. In addition, Kaplan-Meier curves were applied according to mortality and its associated factors using the logrank Mantel-Cox test.
Results: The diagnosis of COVID-19 was mainly made by clinical compatibility (N ¼ 430)...
Late treatment
is less effective
is less effective
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