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Negativización de PCR a SARS-CoV-2 en muestra respiratoria en pacientes con necesidad de asistencia recurrente

Bassets-Bosch et al., Anales de Pediatría, doi:10.1016/j.anpedi.2021.01.006
Apr 2022  
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Time to viral- 29% Improvement Relative Risk HCQ for COVID-19  Bassets-Bosch et al.  LATE TREATMENT Is late treatment with HCQ + AZ beneficial for COVID-19? Retrospective 15 patients in Spain (March - April 2020) Faster viral clearance with HCQ + AZ (not stat. sig., p=0.45) c19hcq.org Bassets-Bosch et al., Anales de Pediat.., Apr 2022 FavorsHCQ Favorscontrol 0 0.5 1 1.5 2+
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020, now with p < 0.00000000001 from 419 studies, recognized in 46 countries.
No treatment is 100% effective. Protocols combine treatments.
5,100+ studies for 109 treatments. c19hcq.org
Retrospective 15 pediatric patients in Spain, showing faster viral clearance with HCQ+AZ, without statistical significance. Treatment time and details are not provided.
time to viral-, 29.2% lower, relative time 0.71, p = 0.45, treatment median 17.0 IQR 16.0 n=5, control median 24.0 IQR 21.0 n=5, onset to clearance.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Bassets-Bosch et al., 30 Apr 2022, retrospective, Spain, peer-reviewed, 5 authors, study period 11 March, 2020 - 30 April, 2020, this trial uses multiple treatments in the treatment arm (combined with AZ) - results of individual treatments may vary. Contact: cristinalarrosaespinosa@gmail.com, segonzalez@vhebron.net, sgonzalezperis@gmail.com.
This PaperHCQAll
Abstract: Anales de Pediatría 96 (2022) 350---371 Figura 1 A) Imagen de dermatoscopia: lesión seudovascular. B) Lesión cupuliforme, irregular, de coloración eritematosa viva. Bibliografía 1. Stefanaki C, Chardalias L, Soura E, Katsarou A, Stratigos A. Paediatric melanoma. J Eur Acad Dermatology Venereol. 2017;31:1604---15. 2. Merkel EA, Mohan LS, Shi K, Panah E, Zhang B, Gerami P. Paediatric melanoma: clinical update, genetic basis, and advances in diagnosis. Lancet Child Adolesc Heal. 2019;3:646---54, http://dx.doi.org/10.1016/S2352-4642(19)30116-6. 3. Lu C, Zhang J, Nagahawatte P, Easton J, Lee S, Liu Z, et al. The genomic landscape of childhood and adolescent melanoma. J Invest Dermatol. 2015;135:816---23, http://dx.doi.org/10.1038/jid.2014.425. 4. Requena C, Rubio L, Traves V, Sanmartín O, Nagore E, Llombart B, et al. Fluorescence in situ hybridization for the differential diagnosis between Spitz naevus and spitzoid melanoma. Histopathology. 2012;61:899---909. 5. Wiesner T, Kutzner H, Cerroni L, Jr MJM, Klaus J, Murali R, et al. Genomic aberrations in spitzoid tumours and their implications for diagnosis, prognosis and therapy. 2017;48:113---31. 6. Stefanaki C, Stefanaki K, Antoniou C, Argyrakos T, Patereli A, Stratigos A, et al. Cell cycle and apoptosis regulators in Spitz Negativización de PCR a SARS-CoV-2 en muestra respiratoria en pacientes con necesidad de asistencia recurrente SARS-CoV-2 PCR negativization in respiratory sample in patients with need for recurring assistance Sra. Editora: Además de las consecuencias en términos de morbimortalidad (especialmente en pacientes adultos), la pandemia de nevi: Comparison with melanomas and common nevi. J Am Acad Dermatol. 2007;56:815---24. Cristina Larrosa a,∗ , Antonio Torrelo b , Luis Madero a y Álvaro Lassaletta a a Unidad de Onco-Hematología Pediátrica y Trasplante de Progenitores Hematopoyéticos, Hospital Universitario Niño Jesús, Madrid, España b Unidad de Dermatología, Hospital Universitario Niño Jesús, Madrid, España ∗ Autor para correspondencia. Correo electrónico: cristinalarrosaespinosa@gmail.com (C. Larrosa). https://doi.org/10.1016/j.anpedi.2021.01.008 1695-4033/ © 2021 Publicado por Elsevier España, S.L.U. en nombre de Asociación Española de Pediatrı́a. Este es un artı́culo Open Access bajo la licencia CC BY-NC-ND (http:// creativecommons.org/licenses/by-nc-nd/4.0/). SARS-CoV-2/COVID-19 ha amenazado con bloquear los circuitos asistenciales habituales. En este sentido, la detección de SARS-CoV-2 en pacientes con necesidad de contacto reiterado con el sistema sanitario ha obligado a establecer estrategias seguras de control clínico y de negativización. Se analizaron los datos de los pacientes diagnosticados de infección por SARS-CoV-2 mediante PCR en muestra respiratoria entre el 11 de marzo y el 30 de abril de 2020 en un hospital terciario pediátrico de referencia de Barcelona (España), a los que se hubiera practicado posteriormente un nuevo estudio para comprobar la negativización de la PCR en aspirado nasofaríngeo. Dicho estudio se realizó a pacientes con necesidad de asistencia seriada en hospitales de día, procedimientos, hospitalizaciones programadas, etc. Para estos controles clínicos y de negativización, y pos357 CARTAS CIENTÍFICAS Tabla 1 Datos de negativización de la PCR a SARS-CoV-2 en función de distintas variables Total de pacientes Grupos de pacientes Número..
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Late treatment
is less effective
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