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All Studies   Meta Analysis    Recent:   

Clinical Characteristics and Outcomes of Hospitalized COVID-19 Patients in a MERS-CoV Referral Hospital during the Peak of the Pandemic

Barry et al., International Journal of Infectious Diseases, doi:10.1016/j.ijid.2021.03.058
Mar 2021  
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Mortality 99% Improvement Relative Risk HCQ for COVID-19  Barry et al.  LATE TREATMENT Is late treatment with HCQ beneficial for COVID-19? Retrospective 605 patients in Saudi Arabia Lower mortality with HCQ (not stat. sig., p=0.6) c19hcq.org Barry et al., Int. J. Infectious Disea.., Mar 2021 FavorsHCQ Favorscontrol 0 0.5 1 1.5 2+
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now with p < 0.00000000001 from 411 studies, recognized in 46 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 75 treatments. c19hcq.org
605 hospitalized patients in Saudi Arabia showing no mortality with HCQ (only 6 patients received HCQ).
risk of death, 98.9% lower, RR 0.01, p = 0.60, treatment 0 of 6 (0.0%), control 91 of 599 (15.2%), NNT 6.6, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Barry et al., 23 Mar 2021, retrospective, Saudi Arabia, peer-reviewed, 14 authors.
This PaperHCQAll
Clinical characteristics and outcomes of hospitalized COVID-19 patients in a MERS-CoV referral hospital during the peak of the pandemic
Mazin Barry, Nouf Althabit, Layan Akkielah, Abdulellah Almohaya, Muath Alotaibi, Sara Alhasani, Abdulwahab Aldrees, Abdulaziz Alrajhi, Ali Alhiji, Fahad Almajid, Aynaa Alsharidi, Fatimah S Al-Shahrani, Naif H Alotaibi, Abdulkarim Alhetheel
International Journal of Infectious Diseases, doi:10.1016/j.ijid.2021.03.058
To describe the clinical characteristics and outcomes of hospitalized coronavirus disease 2019 patients in a middle east respiratory syndrome coronavirus (MERS-CoV) referral hospital during the peak months of the pandemic. Design: A single-center case series of hospitalized individuals with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in King Saud University Medical City (KSUMC), an academic tertiary care hospital in Riyadh, Saudi Arabia. Clinical and biochemical markers were documented. Risks for ventilatory support, intensive care unit (ICU) admission and death are presented. Results: Out of 12,688 individuals tested for SARS-CoV-2 by real time reverse transcriptase polymerase reaction (RT-PCR) from June 1 to August 31, 2020, 2,683 (21%) were positive for COVID-19. Of the latter, 605 (22%) patients required hospitalization with a median age of 55, 368 (61%) were male. The most common comorbidities were hypertension (43%) and diabetes (42%). Most patients presented with fever (66%), dyspnea (65%), cough (61%), elevated IL-6 (93.5%), D-dimer (90.1%), CRP (86.1%), and lymphopenia (41.7%). No MERS-CoV co-infection was detected. Overall, 91 patients (15%) died; risk factors associated with mortality were an age of 65 years or older OR 2.29 [95%CI 1.43-3.67], presence of two or more comorbidities OR 3.17 [95%CI 2.00-5.02], symptoms duration of seven days or less ) lymphopenia ], high CRP OR 2.85 [95%CI 1.1-7.32], high AST OR 2.95 [95% CI 1.77-4.90], high creatinine OR 3.71 [95%CI 2.30-5.99], and high troponin-I OR 2.84 [95%CI 1.33-6.05]. Conclusion: There is a significant increase in severe cases of COVID-19. Mortality was associated with older age, shorter symptom duration, high CRP, low lymphocyte count, and end-organ damage.
Conflict of interest None declared.
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Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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