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All Studies   Meta Analysis    Recent:   

Anticoagulant Use in COVID-19 Patients: A Longitudinal Study From Zanjan, Iran

Azimi Pirsaraei et al., Cureus, doi:10.7759/cureus.66798
Aug 2024  
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Mortality 39% Improvement Relative Risk HCQ  Azimi Pirsaraei et al.  LATE TREATMENT Is late treatment with HCQ beneficial for COVID-19? Retrospective 831 patients in Iran (March - June 2020) Lower mortality with HCQ (not stat. sig., p=0.16) c19hcq.org Azimi Pirsaraei et al., Cureus, August 2024 FavorsHCQ Favorscontrol 0 0.5 1 1.5 2+
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now with p < 0.00000000001 from 417 studies, recognized in 46 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,800+ studies for 102 treatments. c19hcq.org
Retrospective 831 hospitalized COVID-19 patients showing lower mortality with HCQ in unadjusted results, without statistical significance.
This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details.
Study covers aspirin and HCQ.
risk of death, 39.2% lower, RR 0.61, p = 0.16, treatment 70 of 777 (9.0%), control 8 of 54 (14.8%), NNT 17.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Azimi Pirsaraei et al., 13 Aug 2024, retrospective, Iran, peer-reviewed, mean age 57.2, 5 authors, study period 20 March, 2020 - 20 June, 2020. Contact: zmed1996@gmail.com.
This PaperHCQAll
Anticoagulant Use in COVID-19 Patients: A Longitudinal Study From Zanjan, Iran
Vanoushe Azimi Pirsaraei, Manizhe Jozpanahi, Koorosh Kamali, Leila Hamzeloo, Seyedeh Pegah Saeid
Cureus, doi:10.7759/cureus.66798
Background The mortality and morbidity of thrombotic events in patients with coronavirus disease 2019 (COVID-19) are increasing worldwide. The clinical impact of prophylactic anticoagulation regimens among these patients in Iran remains unclear. This study aimed to evaluate the use of prophylactic anticoagulants and outcomes among COVID-19 patients admitted to a tertiary referral hospital. Methodology Patients diagnosed with COVID-19 and hospitalized between March 20 and June 20, 2020, were included in this longitudinal study after obtaining informed consent. Demographic and clinical data were collected from the hospital information system and medical records. Outcomes during this period were also evaluated. The data were entered into the preparation checklist and analyzed using SPSS version 24 software (IBM Corp., Armonk, NY, USA), employing chi-square, Fisher's exact, and Mann-Whitney U tests. Results Of the 831 enrolled patients, 51.9% were female, and 10.6% needed to be admitted to the intensive care unit (ICU). The mean age of the patients was 57.16 ± 17.32 years, and the mortality rate was estimated to be 9.4%. Mortality rates were significantly higher at older ages, in men, patients with ICU admission, severe pulmonary involvement, malignancy, airway obstruction, ischemic heart disease, and previous cerebrovascular accidents. ICU admission and mortality were statistically significantly higher in those who received concurrent prophylactic anticoagulants and aspirin than in other individuals. Conclusions Our study demonstrated that administering prophylactic aspirin with or without anticoagulant agents in COVID-19 patients did not reduce mortality rates or ICU transfers. However, it is worth noting that anticoagulant prescription was associated with a decrease in ICU admissions, which could potentially alleviate the significantly higher mortality rates observed among ICU patients in this study. Further research is needed to explore the potential benefits of anticoagulants in COVID-19 treatment.
Additional Information Author Contributions All authors have reviewed the final version to be published and agreed to be accountable for all aspects of the work. In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. Acquisition, analysis, or interpretation of data
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' '10.1371/journal.pone.0244171', 'journal-title': 'PLoS One'}], 'container-title': 'Cureus', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://www.cureus.com/articles/263779-anticoagulant-use-in-covid-19-patients-a-longitudinal-study-from-zanjan-iran', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2024, 8, 13]], 'date-time': '2024-08-13T21:49:24Z', 'timestamp': 1723585764000}, 'score': 1, 'resource': { 'primary': { 'URL': 'https://www.cureus.com/articles/263779-anticoagulant-use-in-covid-19-patients-a-longitudinal-study-from-zanjan-iran'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2024, 8, 13]]}, 'references-count': 28, 'URL': 'http://dx.doi.org/10.7759/cureus.66798', 'relation': {}, 'ISSN': ['2168-8184'], 'subject': [], 'published': {'date-parts': [[2024, 8, 13]]}}
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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