Alkalinization
Analgesics..
Antiandrogens..
Bromhexine
Budesonide
Cannabidiol
Colchicine
Conv. Plasma
Curcumin
Ensovibep
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Iota-carragee..
Ivermectin
Lactoferrin
Lifestyle..
Melatonin
Metformin
Molnupiravir
Monoclonals..
Nigella Sativa
Nitazoxanide
Nitric Oxide
Paxlovid
Peg.. Lambda
Povidone-Iod..
Quercetin
Remdesivir
Vitamins..
Zinc

Other
Feedback
Home
Home   COVID-19 treatment studies for Hydroxychloroquine  COVID-19 treatment studies for HCQ  C19 studies: HCQ  HCQ   Select treatmentSelect treatmentTreatmentsTreatments
Alkalinization Meta Lactoferrin Meta
Melatonin Meta
Bromhexine Meta Metformin Meta
Budesonide Meta Molnupiravir Meta
Cannabidiol Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta Nitric Oxide Meta
Ensovibep Meta Paxlovid Meta
Famotidine Meta Peg.. Lambda Meta
Favipiravir Meta Povidone-Iod.. Meta
Fluvoxamine Meta Quercetin Meta
Hydroxychlor.. Meta Remdesivir Meta
Iota-carragee.. Meta
Ivermectin Meta Zinc Meta

Other Treatments Global Adoption
All Studies   Meta Analysis   Recent:  
0 0.5 1 1.5 2+ Mortality 1% Improvement Relative Risk Mortality (b) -56% Ventilation -32% ICU admission 16% Hospitalization 23% Hospitalization (b) 40% c19hcq.org Avezum et al. NCT04466540 HCQ RCT EARLY TREATMENT Is early treatment with HCQ beneficial for COVID-19? Double-blind RCT 1,372 patients in Brazil (May 2020 - July 2021) Lower hospitalization with HCQ (not stat. sig., p=0.18) Avezum et al., The Lancet Regional Health - Amer.., doi:10.1016/j.lana.2022.100243 Favors HCQ Favors control
Hydroxychloroquine versus placebo in the treatment of non-hospitalised patients with COVID-19 (COPE – Coalition V): A double-blind, multicentre, randomised, controlled trial
Avezum et al., The Lancet Regional Health - Americas, doi:10.1016/j.lana.2022.100243, NCT04466540 (history)
Avezum et al., Hydroxychloroquine versus placebo in the treatment of non-hospitalised patients with COVID-19 (COPE –.., The Lancet Regional Health - Americas, doi:10.1016/j.lana.2022.100243, NCT04466540
Mar 2022   Source   PDF  
  Twitter
  Facebook
Share
  All Studies   Meta
Authors have not responded to a request for the data.
Outpatient RCT with 687 HCQ and 682 control patients in Brazil, showing lower hospitalization with treatment, not reaching statistical significance. Higher efficacy was seen with treatment <4 days from onset, RR 0.61. The associated meta analysis includes mostly late treatment studies, for example in [Schwartz] the median delay from onset was 7 days. [Omrani] is missing. The values for [Johnston] are incorrect - the study shows 4 hospitalizations in the control arm - RR for this study should be 0.58 instead of 0.78.
risk of death, 0.7% lower, RR 0.99, p = 1.00, treatment 5 of 687 (0.7%), control 5 of 682 (0.7%), NNT 18741, all-cause death.
risk of death, 56.0% higher, HR 1.56, p = 0.54, treatment 5 of 687 (0.7%), control 5 of 682 (0.7%), adjusted per study, univariate Firth's penalized likelihood.
risk of mechanical ventilation, 32.4% higher, RR 1.32, p = 0.79, treatment 8 of 687 (1.2%), control 6 of 682 (0.9%).
risk of ICU admission, 16.4% lower, RR 0.84, p = 0.61, treatment 16 of 687 (2.3%), control 19 of 682 (2.8%), NNT 219.
risk of hospitalization, 23.5% lower, RR 0.77, p = 0.18, treatment 44 of 689 (6.4%), control 57 of 683 (8.3%), NNT 51.
risk of hospitalization, 40.0% lower, RR 0.60, p = 0.15, treatment 267, control 265, <4 days.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Avezum et al., 31 Mar 2022, Double Blind Randomized Controlled Trial, Brazil, peer-reviewed, 40 authors, study period 12 May, 2020 - 7 July, 2021, average treatment delay 4.0 days, dosage 400mg bid day 1, 200mg bid days 2-7, trial NCT04466540 (history).
All Studies   Meta Analysis   Submit Updates or Corrections
This PaperHCQAll
Abstract: Articles Hydroxychloroquine versus placebo in the treatment of non-hospitalised patients with COVID-19 (COPE − Coalition V): A double-blind, multicentre, randomised, controlled trial  Alvaro Avezum,a* Gustavo B F Oliveira,a Haliton Oliveira,a Rosa C Lucchetta,a Valeria F A Pereira,b Andre L Dabarian,b Ricardo DO Vieira,c Daniel V Silva,c Adrian P M Kormann,d Alexandre P Tognon,e Ricardo De Gasperi,f Mauro E Hernandes,g Audes D M Feitosa,h Agnaldo Piscopo,i Andre S Souza,j Carlos H Miguel,k Vinicius O Nogueira,l Cesar Minelli,m Carlos C Magalh~ aes,n Karen M L Morejon,o Letícia S Bicudo,p Germano E C Souza,q Marco A M Gomes,r Jose J F Raposo Fo,s Alexandre V Schwarzbold,t Alexandre Zilli,u Roberto B Amazonas,v Frederico R Moreira,a Lucas B O Alves,a Silvia R L Assis,ac Precil D M M Neves,a Jessica Y Matuoka,a Icaro Boszczowski,a Daniela G M Catarino,a Viviane C Veiga,w Luciano C P Azevedo,x Regis G Rosa,y Renato D Lopes,z,aa Alexandre B Cavalcanti,ab and Otavio Berwanger ac, on behalf of the COPE - COALITION COVID-19 Brazil V Investigators 1 a International Research Center, Hospital Alem~ao Oswaldo Cruz, Rua Treze de Maio, 1815; Bloco A, 1o SS, S~ao Paulo, SP 01327-001, Brazil b stica, Barueri, SP, Brazil ALPHACOR Cardiologia Clínica e Diagno c Hospital e Clínica S~ao Roque, Ipia u, BA, Brazil d AngioCor, Blumenau, SC, Brazil e Hospital S~ao Vicente de Paulo, Passo Fundo, RS, Brazil f Hospital Tacchini, Bento Gonçalves, RS, Brazil g rdia de Votuporanga, Votuporanga, SP, Brazil Santa Casa de Miserico h Pronto Socorro Cardiol ogico Universitario - Prof. Luiz Tavares (PROCAPE), Recife, PE, Brazil i rdia de Araras, SP, Brazil Santa Casa de Miserico j Santos Dumont Hospital Caraguatatuba, SP, Brazil k Estrategia Sa ude da Família Dr. Jo~ao Paccola Primo. Prefeitura Municipal, Lençois Paulista, SP, Brazil l Centro de Pesquisa em Medicina Tropical de Rond^ onia. Porto Velho, RO, Brazil m Hospital Carlos Fernando Malzoni. Mat~ao, SP, Brazil n Hospital Policlin. S~ao Jos e dos Campos, SP, Brazil o Hospital da Unimed. Ribeir~ao Preto, SP, Brazil p Irmandade de Miseric ordia do Hospital da Santa Casa de Monte Alto, SP, Brazil q Hospital Regional de S~ao Jos e dos Campos, SP, Brazil r Centro de Pesquisas Clínicas Dr. Marco Mota, Macei o, AL, Brazil s polis, Cordeiro polis, SP, Brazil Hospital de Cordeiro t Universidade Federal de Santa Maria, Santa Maria, RS, Brazil u Dux Medicina, Jundiaí, SP, Brazil v EMS Pharma, Hortol^andia, SP, Brazil w Intensive Care Unit, BP − A Benefic^ encia Portuguesa de S~ao Paulo, SP, Brazil x Research and Education Institute, Hospital Sírio Liban^ es, S~ao Paulo, SP, Brazil y Hospital Moinhos de Vento, Porto Alegre, RS, Brazil z Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA aa Brazilian Clinical Research Institute, S~ao Paulo, SP, Brazil ab HCor Research Institute, S~ao Paulo, SP, Brazil ac Academic Research Organization - Hospital Israelita Albert Einstein, S~ao Paulo, SP, Brazil Summary Background Previous Randomised controlled trials (RCT) evaluating chloroquine and hydroxychloroquine in nonhospitalised COVID-19 patients have found no significant difference in hospitalisation rates. However, low statistical power precluded definitive answers. The Lancet Regional Health - Americas 2022;11: 100243 Published online xxx https://doi.org/10.1016/j. lana.2022.100243 *Corresponding author.  Avezum). E-mail address: aavezum@haoc.com.br (A. 1 COPE - COALITION..
Loading..
Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit