ICU and ventilator mortality among critically ill adults with COVID-19
Retrospective 217 critically ill patients, 114 receiving HCQ, showing no significant difference in mortality.
risk of death, 2.8% higher, RR 1.03, p = 1.00, treatment 33 of 114 (28.9%), control 29 of 103 (28.2%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Auld et al., 26 Apr 2020, retrospective, USA, peer-reviewed, 14 authors.
Abstract: Online Brief Reports
ICU and Ventilator Mortality Among Critically
Ill Adults With Coronavirus Disease 2019*
Sara C. Auld, MD, MSc1–3; Mark Caridi-Scheible, MD1,4; James M. Blum, MD1,4,5,6; Chad Robichaux, MPH5,6;
Colleen Kraft, MD, MSc7,8; Jesse T. Jacob, MD, MSc3,7; Craig S. Jabaley, MD1,4; David Carpenter, PA1;
Roberta Kaplow, PhD, RN9; Alfonso C. Hernandez-Romieu, MD, MPH7; Max W. Adelman, MD7;
Greg S. Martin, MD, MSc1,2,6; Craig M. Coopersmith, MD1,10; David J. Murphy, MD, PhD1,2,11; and the
Emory COVID-19 Quality and Clinical Research Collaborative
Objectives: To determine mortality rates among adults with critical
illness from coronavirus disease 2019.
Design: Observational cohort study of patients admitted from
March 6, 2020, to April 17, 2020.
Setting: Six coronavirus disease 2019 designated ICUs at three
hospitals within an academic health center network in Atlanta,
Georgia, United States.
Patients: Adults greater than or equal to 18 years old with confirmed severe acute respiratory syndrome-CoV-2 disease who
were admitted to an ICU during the study period.
Measurements and Main Results: Among 217 critically ill patients,
mortality for those who required mechanical ventilation was 35.7%
(59/165), with 4.8% of patients (8/165) still on the ventilator at
the time of this report. Overall mortality to date in this critically ill
cohort is 30.9% (67/217) and 60.4% (131/217) patients have
survived to hospital discharge. Mortality was significantly associ-
*See also p. 1398.
Emory Critical Care Center (ECCC), Atlanta, GA.
Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA.
Department of Epidemiology, Emory University Rollins School of Public
Health, Atlanta, GA.
Department of Anesthesiology, Emory University School of Medicine, Atlanta, GA.
Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA.
Georgia Clinical and Translational Science Alliance (CTSA), Atlanta, GA.
Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA.
Department of Pathology, Emory University School of Medicine, Atlanta, GA.
Emory University Hospital, Emory Healthcare, Atlanta, GA.
Department of Surgery, Emory University School of Medicine, Atlanta, GA.
Office of Quality and Risk, Emory Healthcare, Atlanta, GA.
Copyright © 2020 by the Society of Critical Care Medicine and Wolters
Kluwer Health, Inc. All Rights Reserved.
Critical Care Medicine
ated with older age, lower body mass index, chronic renal disease,
higher Sequential Organ Failure Assessment score, lower Pao2/
Fio2 ratio, higher d-dimer, higher C-reactive protein, and receipt of
mechanical ventilation, vasopressors, renal replacement therapy,
or vasodilator therapy.
Conclusions: Despite multiple reports of mortality rates exceeding
50% among critically ill adults with coronavirus disease 2019,
particularly among those requiring mechanical ventilation, our
early experience indicates that many patients survive their critical
illness. (Crit Care Med 2020; 48:e799–e804)
Key Words: coronavirus; critical care; intubation; mortality;
respiration, artificial; respiratory distress..
is less effective
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