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0 0.5 1 1.5 2+ Mortality -3% Improvement Relative Risk HCQ for COVID-19  Auld et al.  LATE TREATMENT Is late treatment with HCQ beneficial for COVID-19? Retrospective 217 patients in the USA No significant difference in mortality Auld et al., Critical Care Medicine, Apr 2020 Favors HCQ Favors control

ICU and ventilator mortality among critically ill adults with COVID-19

Auld et al., Critical Care Medicine, doi:10.1097/ccm.0000000000004457
Apr 2020  
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Retrospective 217 critically ill patients, 114 receiving HCQ, showing no significant difference in mortality.
risk of death, 2.8% higher, RR 1.03, p = 1.00, treatment 33 of 114 (28.9%), control 29 of 103 (28.2%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Auld et al., 26 Apr 2020, retrospective, USA, peer-reviewed, 14 authors.
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ICU and Ventilator Mortality Among Critically Ill Adults With Coronavirus Disease 2019*
MD, MSc Sara C Auld, MD Mark Caridi-Scheible, MD James M Blum, MPH Chad Robichaux, MD, MSc Colleen Kraft, MD, MSc Jesse T Jacob, MD Craig S Jabaley, PA David Carpenter, PhD, RN Roberta Kaplow, MD, MPH Alfonso C Hernandez-Romieu, MD Max W Adelman, MD, MSc Greg S Martin, MD Craig M Coopersmith, MD, PhD David J Murphy
Critical Care Medicine, doi:10.1097/ccm.0000000000004457
Patients: Adults greater than or equal to 18 years old with confirmed severe acute respiratory syndrome-CoV-2 disease who were admitted to an ICU during the study period. Interventions: None. Measurements and Main Results: Among 217 critically ill patients, mortality for those who required mechanical ventilation was 35.7% (59/165), with 4.8% of patients (8/165) still on the ventilator at the time of this report. Overall mortality to date in this critically ill cohort is 30.9% (67/217) and 60.4% (131/217) patients have survived to hospital discharge. Mortality was significantly associ-ated with older age, lower body mass index, chronic renal disease, higher Sequential Organ Failure Assessment score, lower Pao 2 / Fio 2 ratio, higher d-dimer, higher C-reactive protein, and receipt of mechanical ventilation, vasopressors, renal replacement therapy, or vasodilator therapy. Conclusions: Despite multiple reports of mortality rates exceeding 50% among critically ill adults with coronavirus disease 2019, particularly among those requiring mechanical ventilation, our early experience indicates that many patients survive their critical illness. (Crit Care Med 2020; 48:e799-e804)
For information regarding this article, E-mail: The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Adelman, Arno, Auld, Barnes, Bender et al., We would like to extend our most profound thanks and gratitude to our colleagues in the Emory Critical Care Center and Emory Healthcare who have worked so hard to provide excellent clinical care during this global pandemic. Emory COVID-19 Quality and Clinical Research Collaborative Members, REFERENCES
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Late treatment
is less effective
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