ICU and ventilator mortality among critically ill adults with COVID-19
Retrospective 217 critically ill patients, 114 receiving HCQ, showing no significant difference in mortality.
risk of death, 2.8% higher, RR 1.03, p = 1.00, treatment 33 of 114 (28.9%), control 29 of 103 (28.2%).
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Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
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Auld et al., 26 Apr 2020, retrospective, USA, peer-reviewed, 14 authors.
Abstract: Online Brief Reports
ICU and Ventilator Mortality Among Critically
Ill Adults With Coronavirus Disease 2019*
Sara C. Auld, MD, MSc1–3; Mark Caridi-Scheible, MD1,4; James M. Blum, MD1,4,5,6; Chad Robichaux, MPH5,6;
Colleen Kraft, MD, MSc7,8; Jesse T. Jacob, MD, MSc3,7; Craig S. Jabaley, MD1,4; David Carpenter, PA1;
Roberta Kaplow, PhD, RN9; Alfonso C. Hernandez-Romieu, MD, MPH7; Max W. Adelman, MD7;
Greg S. Martin, MD, MSc1,2,6; Craig M. Coopersmith, MD1,10; David J. Murphy, MD, PhD1,2,11; and the
Emory COVID-19 Quality and Clinical Research Collaborative
Objectives: To determine mortality rates among adults with critical
illness from coronavirus disease 2019.
Design: Observational cohort study of patients admitted from
March 6, 2020, to April 17, 2020.
Setting: Six coronavirus disease 2019 designated ICUs at three
hospitals within an academic health center network in Atlanta,
Georgia, United States.
Patients: Adults greater than or equal to 18 years old with confirmed severe acute respiratory syndrome-CoV-2 disease who
were admitted to an ICU during the study period.
Interventions: None.
Measurements and Main Results: Among 217 critically ill patients,
mortality for those who required mechanical ventilation was 35.7%
(59/165), with 4.8% of patients (8/165) still on the ventilator at
the time of this report. Overall mortality to date in this critically ill
cohort is 30.9% (67/217) and 60.4% (131/217) patients have
survived to hospital discharge. Mortality was significantly associ-
*See also p. 1398.
1
Emory Critical Care Center (ECCC), Atlanta, GA.
2
Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA.
3
Department of Epidemiology, Emory University Rollins School of Public
Health, Atlanta, GA.
4
Department of Anesthesiology, Emory University School of Medicine, Atlanta, GA.
5
Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA.
6
Georgia Clinical and Translational Science Alliance (CTSA), Atlanta, GA.
7
Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA.
8
Department of Pathology, Emory University School of Medicine, Atlanta, GA.
9
Emory University Hospital, Emory Healthcare, Atlanta, GA.
10
Department of Surgery, Emory University School of Medicine, Atlanta, GA.
11
Office of Quality and Risk, Emory Healthcare, Atlanta, GA.
Copyright © 2020 by the Society of Critical Care Medicine and Wolters
Kluwer Health, Inc. All Rights Reserved.
DOI: 10.1097/CCM.0000000000004457
Critical Care Medicine
ated with older age, lower body mass index, chronic renal disease,
higher Sequential Organ Failure Assessment score, lower Pao2/
Fio2 ratio, higher d-dimer, higher C-reactive protein, and receipt of
mechanical ventilation, vasopressors, renal replacement therapy,
or vasodilator therapy.
Conclusions: Despite multiple reports of mortality rates exceeding
50% among critically ill adults with coronavirus disease 2019,
particularly among those requiring mechanical ventilation, our
early experience indicates that many patients survive their critical
illness. (Crit Care Med 2020; 48:e799–e804)
Key Words: coronavirus; critical care; intubation; mortality;
respiration, artificial; respiratory distress..
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