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0 0.5 1 1.5 2+ Mortality 56% Improvement Relative Risk Progression 54% Time to viral- 7% primary Time to viral- (b) 7% primary Progression (b) -150% early Time to viral- (c) 43% early, primary Time to viral- (d) 36% early, primary Atipornwanich et al. NCT04303299 HCQ RCT LATE TREATMENT Is late treatment with HCQ+combined treatments beneficial for COVID-19? RCT 200 patients in Thailand Trial compares with another combination of treatments Lower progression with HCQ+combined treatments (p=0.025) Atipornwanich et al., SSRN Electronic J., doi:10.2139/ssrn.3936499 Favors HCQ Favors oseltamivir/..
Various Combinations of Favipiravir, Lopinavir-Ritonavir, Darunavir-Ritonavir, High-Dose Oseltamivir, and Hydroxychloroquine for the Treatment of COVID-19: A Randomized Controlled Trial (FIGHT-COVID-19 Study)
Atipornwanich et al., SSRN Electronic Journal, doi:10.2139/ssrn.3936499, NCT04303299 (history)
Atipornwanich et al., Various Combinations of Favipiravir, Lopinavir-Ritonavir, Darunavir-Ritonavir, High-Dose Oseltamivir, and.., SSRN Electronic Journal, doi:10.2139/ssrn.3936499, NCT04303299
Oct 2021   Source   PDF  
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RCT 320 patients in Thailand, showing significantly lower progression with HCQ for moderate/severe patients, and faster viral clearance with mild patients (statistically significant for 800mg). There are two sets of results - for moderate/severe patients, and for mild patients. There was no mortality for mild patients. NCT04303299 (history).
risk of death, 56.2% lower, RR 0.44, p = 0.07, treatment 7 of 100 (7.0%), control 16 of 100 (16.0%), NNT 11, moderate/severe, HCQ arms vs. non-HCQ arms.
risk of progression, 54.2% lower, RR 0.46, p = 0.02, treatment 11 of 100 (11.0%), control 24 of 100 (24.0%), NNT 7.7, moderate/severe, HCQ arms vs. non-HCQ arms.
time to viral-, 7.1% lower, relative time 0.93, p = 0.51, treatment mean 10.4 (±6.3) n=50, control mean 11.2 (±5.7) n=50, moderate/severe, oseltamivir arms, primary outcome.
time to viral-, 6.9% lower, relative time 0.93, p = 0.47, treatment mean 9.5 (±5.0) n=50, control mean 10.2 (±4.6) n=50, moderate/severe, favipiravir arms, primary outcome.
risk of progression, 150.0% higher, RR 2.50, p = 1.00, treatment 1 of 60 (1.7%), control 0 of 30 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm), mild, early treatment result.
time to viral-, 43.3% lower, relative time 0.57, p = 0.04, treatment mean 8.9 (±6.0) n=30, control mean 15.7 (±16.7) n=30, mild, HCQ 800, primary outcome, early treatment result.
time to viral-, 36.3% lower, relative time 0.64, p = 0.09, treatment mean 10.0 (±6.9) n=30, control mean 15.7 (±16.7) n=30, mild, HCQ 400, primary outcome, early treatment result.
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Atipornwanich et al., 5 Oct 2021, Randomized Controlled Trial, Thailand, peer-reviewed, 16 authors, dosage 400mg days 1-14, 800mg/day or 400mg/day, this trial compares with another treatment - results may be better when compared to placebo, this trial uses multiple treatments in the treatment arm (combined with oseltamivir/favipiravir and duranivir/ritonavir for moderate/severe, oseltamivir and duranivir/ritonavir for mild) - results of individual treatments may vary, trial NCT04303299 (history).
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This PaperHCQAll
Abstract: Various combinations of Favipiravir, Lopinavir-Ritonavir, Darunavir-Ritonavir, 2 high-dose Oseltamivir, and Hydroxychloroquine for the treatment of Covid-19: A 3 randomized controlled trial. (FIGHT-COVID-19 Study) 4 Kriangsak Atipornwanich, M.D. 1,2, Subsai Kongsaengdao, M.D. 1,2, Piyathida 5 Harnsomburana, M.D. 1,2, Rienthong Nanna, M.D. 3, Chatchawan Chtuparisute, M.D. 3, 6 Piamlarp Saengsayan, M.D.4, Kittima Bangpattanasiri, M.D. 4, Weerawat Manosuthi, M.D. 7 5, Narumol Sawanpanyalert, M.D. 6, Attasit Srisubat, M.D. 6, Somchai Thanasithichai, M.D. 8 6, Benchalak Maneeton, M.D. 7, Narong Maneeton, M.D. 7, Chuthamanee Suthisisang, B. 9 Pharm, PhD. 8, Jaturong Pratuangdejkul, B. Pharm, PhD. 8, and Somsak Akksilp, M.D. 2,6 pe er re v iew ed 1 10 Affiliations: 11 1 12 of Public Health, Bangkok, Thailand. 13 2 Department of Medicine, College of Medicine, Rangsit University, Bangkok, Thailand. 14 3 Department of Medicine, Monkutwattana Hospital, Bangkok, Thailand. 15 4 Department of Medicine, Central Chest Institute of Thailand, Nonthaburi, Thailand. 16 5 Department of Infectious Disease, Bamrasnaradura Infectious Disease Institute, 17 Nonthaburi, Thailand. 18 6 Department of Medical Services, Ministry of Public Health, Nonthaburi, Thailand. 19 7 Department of Psychiatry, Faculty of Medicine, Chiang Mai University, Chiang Mai, 20 Thailand 21 8 ot tn rin Correspondence: Associate Professor Subsai Kongsaengdao, M.D., Division of Neurology, Department of Medicine, 2 Rajavithi Hospital (Victory Monument), Pr 23 Faculty of Pharmacy, Mahidol University, Bangkok Thailand, ep 22 Department of Medicine, Rajavithi Hospital, Department of Medical Services, Ministry 24 Ratchathewi Road, Bangkok 10400, Thailand, Tel +66 22 062 900 Ext 6120, 25 Fax +66 23 545 477, Email FIGHT COVID-19 study {NCT04303299} 1 This preprint research paper has not been peer reviewed. Electronic copy available at: ABSTRACT 27 BACKGROUND 28 Monotherapy with Remdesivir, Favipiravir, Lopinavir-Ritonavir, or Hydroxychloroquine 29 has been evaluated for the treatment of coronavirus disease 2019 (Covid-19). No 30 antiviral agents have yet been shown to be efficacious in terms of viral clearance and 31 reduction of death in moderate to severe Covid-19 in randomized controlled trials. 32 METHODS 33 We conducted an open-label, randomized, controlled trial of various oral combinations 34 of Favipiravir, Lopinavir-Ritonavir, Darunavir-Ritonavir, high-dose Oseltamivir, and 35 Hydroxychloroquine in adults who were hospitalized with Covid-19. Ninety patients 36 were randomly assigned to receive either 1) high-dose Oseltamivir and 37 Hydroxychloroquine, 2) Lopinavir-Ritonavir and high-dose Oseltamivir, or 3) Darunavir- 38 Ritonavir, high-dose Oseltamivir, and Hydroxychloroquine, compared to thirty voluntary 39 quarantine patients without antiviral agent for mild Covid-19. In addition, two hundred 40 patients were randomly assigned to receive 1) high-dose Oseltamivir and Lopinavir- 41 Ritonavir, 2) Favipiravir and Lopinavir-Ritonavir, 3) high-dose Oseltamivir and 42 Darunavir-Ritonavir, or 4) Favipiravir and Darunavir-Ritonavir and Hydroxychloroquine 43 for moderate to severe Covid-19. 44 RESULTS 45 A total of 320 patients were enrolled. Those mild Covid-19 patients who received high- 46 dose Oseltamivir and Hydroxychloroquine had a..
Late treatment
is less effective
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