Conv. Plasma
Nigella Sativa

All HCQ studies
Meta analysis
study COVID-19 treatment researchHCQHCQ (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality 60% Improvement Relative Risk HCQ for COVID-19  Assad et al.  LATE TREATMENT Is late treatment with HCQ beneficial for COVID-19? Retrospective 291 patients in Iraq (June - September 2020) Lower mortality with HCQ (p=0.0019) Assad, H., Current Issues in Pharmacy .., Oct 2022 Favors HCQ Favors control

Pharmacotherapy prescribing pattern and outcome for hospitalized patients with severe and critical COVID-19

Assad, H., Current Issues in Pharmacy and Medical Sciences, doi:10.2478/cipms-2022-0020
Oct 2022  
  Source   PDF   All   Meta
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
*, now known with p < 0.00000000001 from 421 studies, recognized in 42 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments.
Retrospective 346 hospitalized patients in Iraq, showing lower mortality with HCQ in unadjusted results. HCQ results are only provided within the 93% of patients treated with enoxaparin.
This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details; confounding by time possible, propensity to use HCQ changed significantly during the study period.
risk of death, 59.7% lower, RR 0.40, p = 0.002, treatment 9 of 72 (12.5%), control 68 of 219 (31.1%), NNT 5.4, enoxaparin+HCQ vs. enoxaparin.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Assad et al., 21 Oct 2022, retrospective, Iraq, peer-reviewed, 1 author, study period June 2020 - September 2020. Contact:
This PaperHCQAll
Pharmacotherapy prescribing pattern and outcome for hospitalized patients with severe and critical COVID-19
Hayder Assad
Current Issues in Pharmacy and Medical Sciences, doi:10.2478/cipms-2022-0020
INTRODUCTION Coronavirus Disease 2019 (COVID-19) is a pandemic disease originating in late 2019 in the People's Republic of China that spread rapidly worldwide [1]. The first reported case in the Najaf governorate, Iraq, was confirmed on February 24, 2020 [2]. As of early June 2021, the global reported cases of COVID-19 have exceeded 170 million with over 3 million deaths [3]. The clinical spectrum of this illness ranges from asymptomatic infection, to acute respiratory distress syndrome (ARDS), circulatory shock, multiorgan failure, and ultimately death [4] . The death rate related to COVID-19 is relatively high -ranging from 5% to 35%, especially in elderly patients and those who have comorbidities [5] . Although different treatment strategies have been explored and used based on emergency approval and evidence-based
ORCID iDs Hayder Assad 
Alsharidah, Ayed, Ameen, Alhuraish, Rouheldeen et al., COVID-19 convalescent plasma treatment of moderate and severe cases of SARS-CoV-2 infection: A multicenter interventional study, Int J Infect Dis
Arshad, Kilgore, Chaudhry, Jacobsen, Wang et al., Treatment with hydroxychloroquine, azithromycin, and combination in patients hospitalized with COVID-19, Int J Infect Dis
Bajwah, Wilcock, Towers, Costantini, Bausewein et al., Managing the supportive care needs of those affected by COVID-19, Eur Respir J
Beigel, Tomashek, Dodd, Mehta, Zingman et al., Remdesivir for the treatment of COVID-19 -Final Report, N Engl J Med
Best, Kong, Kaplan-Lewis, Brawley, Baden et al., Treatment patterns in US patients hospitalized with COVID-19 and pulmonary involvement, J Med Virol
Campos Dm De, Fulco, De Oliveira, Oliveira, SARS-CoV-2 virus infection: Targets and antiviral pharmacological strategies, J Evid Based Med
Chappell, Horby, Lim, Emberson, Mafham et al., Dexamethasone in hospitalized patients with COVID-19 -preliminary report, N Engl J Med
Chibber, Haq, Ahmed, Andrabi, Singh, Advances in the possible treatment of COVID-19: A review, Eur J Pharmacol
Freedberg, Conigliaro, Wang, Tracey, Callahan et al., Famotidine use is associated with improved clinical outcomes in hospitalized COVID-19 patients: A propensity score matched retrospective cohort study, Gastroenterol
Kewan, Covut, Mj, Rose, Gopalakrishna et al., Tocilizumab for treatment of patients with severe COVID-19: A retrospective cohort study, E Clinical Medicine
Lin, Schneeweiss, Tesfaye, Andrea, Liu et al., Pharmacotherapy for hospitalized patients with COVID-19: Treatment patterns by disease severity, Drugs
Mk, Ma, Incidence of the COVID-19 in Iraq -Implications for travellers, Travel Med Infect Dis
Padhy, Mohanty, Das, Meher, Therapeutic potential of ivermectin as add on treatment in COVID 19: A systematic review and meta-analysis, J Pharm Pharm Sci
Phelan, Katz, Lo, The Novel Coronavirus Originating in Wuhan, China: Challenges for Global Health Governance, JAMA
Rattanaumpawan, Jirajariyavej, Lerdlamyong, Palavutitotai, Saiyarin, Real-world experience with favipiravir for treatment of COVID-19 in Thailand: Results from a multi-center observational study, doi:10.1101/2020.06.24.20133249
Richardson, Hirsch, Narasimhan, Crawford, Mcginn et al., Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area, JAMA
Sahebnasagh, Avan, Saghafi, Mojtahedzadeh, Sadremomtaz et al., Pharmacological treatments of COVID-19, Pharmacol Rep
Salazar, Christensen, Graviss, Nguyen, Castillo et al., Treatment of Coronavirus Disease 2019 patients with convalescent plasma reveals a signal of significantly decreased mortality, Am J Pathol
Sanders, Monogue, Jodlowski, Cutrell, Pharmacologic treatments for Coronavirus Disease 2019 (COVID-19): A review, JAMA
Wang, Hu, Hu, Zhu, Liu et al., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China, JAMA
Wang, Zhang, Du, Du, Zhao et al., Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebocontrolled, multicentre trial, Lancet
Watanabe, Kwon, Abeles, Jia, Mehta, Medication use patterns in hospitalized patients with COVID-19 in California During the pandemic, JAMA Netw Open
Who, None
Who, None
Zanasi, Mazzolini, Kantar, A reappraisal of the mucoactive activity and clinical efficacy of bromhexine, Multidiscip Respir Med
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop