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0 0.5 1 1.5 2+ Hospitalization time 18% Improvement Relative Risk HCQ for COVID-19  Alqassieh et al.  LATE TREATMENT Is late treatment with HCQ beneficial for COVID-19? Prospective study of 131 patients in Jordan Shorter hospitalization with HCQ (not stat. sig., p=0.11) Alqassieh et al., F1000Research, Prepr.., Dec 2020 Favors HCQ Favors control

Clinical characteristics and predictors of the duration of hospital stay in COVID-19 patients in Jordan

Alqassieh et al., F1000Research, Preprint
Dec 2020  
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HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
*, now known with p < 0.00000000001 from 422 studies, recognized in 42 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments.
Prospective observational study of 131 COVID-19 patients in Jordan, showing 18% shorter hospital stay with HCQ, p = 0.11.
hospitalization time, 18.2% lower, relative time 0.82, p = 0.11, treatment 63, control 68.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Alqassieh et al., 10 Dec 2020, prospective, Jordan, preprint, 10 authors.
This PaperHCQAll
Clinical characteristics and predictors of the duration of hospital stay in COVID-19 patients in Jordan
Rami S Alqassieh, Isam K Bsisu, Mohammed Qussay Al-Sabbagh, Naser M El-Hammuri, Moh’d A Yousef, Mohammad A El Jarbeh, Ahmed A Sharqawi, Heba Z Smadi, Sami A Abu-Halaweh, Mohammad M Abufaraj
F1000Research, doi:10.12688/f1000research.27419.1
Background: On March 11th, 2020, the World Health Organization (WHO) declared coronavirus disease 2019 (COVID-19) as a global pandemic. Healthcare systems in low-and middle-income countries may face serious limitations during a pandemic, for which understanding the predictors of prolonged hospital stay are crucial in decreasing the mortality rate. The aim of this study was to investigate the predictors of increased length of hospitalization among COVID-19 patients. Methods: In this prospective study, we investigated the effect of presenting symptoms and laboratory investigations on the duration of hospitalization of 131 COVID-19 patients at a tertiary hospital in Jordan from March 17th to April 9th, 2020. Results: Patients median age was 24 years [interquartile range (IQR): 8-39], of which 67 (51.15%) were males and 64 (48.85%) were females. Smokers had shorter in-hospital stay (OR: -3.52; 95% CI: -6.73 to -0.32; P=0.03). Taste loss (OR: 5.1; 95% CI: 1.95 to 8.25; P<0.01) and chills or rigors (OR: 4.08; 95% CI: 0.73 to 7.43; P=0.02) were the symptoms significantly associated with increased in-hospital stay, while those who had malaise (OR: -4.98; 95% CI: -8.42 to -1.59; P<0.01) and high white blood cell (WBC) count (OR: -0.74; 95% CI: -1.31 to -0.17; P=0.01) had faster recovery. Conclusions: Our study found that the most common presenting Open Peer Review Reviewer Status
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Late treatment
is less effective
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