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0 0.5 1 1.5 2+ Mortality -8% Improvement Relative Risk Hospitalization 18% Mortality (b) -19% Hospitalization (b) 12% c19hcq.org Alegiani et al. HCQ for COVID-19 PrEP Favors HCQ Favors control
Risk of COVID-19 hospitalization and mortality in rheumatic patients treated with hydroxychloroquine or other conventional DMARDs in Italy
Alegiani et al., Rheumatology, doi:10.1093/rheumatology/keab348
15 Apr 2021    Source   PDF   Share   Tweet
Retrospective database analysis case control study of rheumatic patients. When compared with other cDMARDs, HCQ users had significantly lower hospitalization, however there was no significant difference in mortality. Results differ significantly from previous studies, for example showing mortality OR 0.94 [0.83-1.06] for patients with rheumatic disease and mortality OR 0.88 [0.74-1.05] for patients with RA/SLE. Other research shows that the risk of COVID-19 for systemic autoimmune disease patients is much higher overall.
risk of death, 8.0% higher, OR 1.08, p = 0.64, HCQ vs. other cDMARDs, RR approximated with OR.
risk of hospitalization, 18.0% lower, OR 0.82, p = 0.03, HCQ vs. other cDMARDs, RR approximated with OR.
risk of death, 19.0% higher, OR 1.19, p = 0.32, HCQ vs. MTX, RR approximated with OR.
risk of hospitalization, 12.0% lower, OR 0.88, p = 0.17, HCQ vs. MTX, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Alegiani et al., 15 Apr 2021, retrospective, case control, database analysis, Italy, peer-reviewed, 16 authors.
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